San Francisco Vacation Packages for 2026

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Top Hotel Deals

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
1.92 km from San Francisco
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in ...
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
2.07 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
1.93 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Aloft by Marriott Panama

Aloft by Marriott Panama

3.5 out of 5
Via Israel & Calle 76 Panama City Panama
0.61 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
0.75 km from San Francisco
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
1.05 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
2.31 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
2.01 km from San Francisco
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
0.58 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

4 out of 5
CALLE RAMON H JURADO EDIFICO P Panama City
1.71 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Boutique Apartments Panamá Coco del Mar

Boutique Apartments Panamá Coco del Mar

3.5 out of 5
Av. Cincuentenario Panama City Provincia de Panamá
1.23 km from San Francisco
Stay at this apartment in Panama City. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Albrook Shopping Mall and Panama Viejo are located ...
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
1.99 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
15.65 km from San Francisco
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
13.34 km from San Francisco
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
2 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Mon, Jan 25 - Tue, Jan 26
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$264 Roundtrip, found 10 hours ago
$264
Roundtrip
found 10 hours ago
Select Copa flight, departing Mon, Jan 25 from Juan Santamaría Intl. to Tocumen Intl., returning Tue, Jan 26, priced at $264 found 10 hours ago
avianca
Mon, Jan 25 - Tue, Jan 26
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$290 Roundtrip, found 10 hours ago
$290
Roundtrip
found 10 hours ago
Select avianca flight, departing Mon, Jan 25 from Juan Santamaría Intl. to Tocumen Intl., returning Tue, Jan 26, priced at $290 found 10 hours ago
American Airlines
Thu, Sep 24 - Tue, Sep 29
MIA
Miami Intl.
PTY
Tocumen Intl.
$442 Roundtrip, found 3 days ago
$442
Roundtrip
found 3 days ago
Select American Airlines flight, departing Thu, Sep 24 from Miami Intl. to Tocumen Intl., returning Tue, Sep 29, priced at $442 found 3 days ago
United
Tue, Oct 20 - Mon, Oct 26
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$467 Roundtrip, found 1 day ago
$467
Roundtrip
found 1 day ago
Select United flight, departing Tue, Oct 20 from Fort Lauderdale - Hollywood Intl. to Tocumen Intl., returning Mon, Oct 26, priced at $467 found 1 day ago
Delta
Thu, Aug 20 - Thu, Aug 27
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$616 Roundtrip, found 4 days ago
$616
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Aug 20 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Thu, Aug 27, priced at $616 found 4 days ago