San Francisco Vacation Packages for 2026

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Top Hotel Deals

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
2.07 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
1.92 km from San Francisco
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
2.31 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
1.9 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
0.75 km from San Francisco
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
2.01 km from San Francisco
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
0.58 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
Aloft Panama

Aloft Panama

3.5 out of 5
Via Israel & Calle 76 Panama City Panama
0.64 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
1.05 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

4 out of 5
CALLE RAMON H JURADO EDIFICO P Panama City
1.71 km from San Francisco
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
San Francisco by Wynwood House

San Francisco by Wynwood House

3 out of 5
C. 73 Este 12250 Panama City Provincia de Panamá
0.48 km from San Francisco
Stay at this aparthotel in Panama City. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Multiplaza ...
ESHEL SUITES PANAMA

ESHEL SUITES PANAMA

2.5 out of 5
9 C. Tomas Gabriel Duque Panama City Panamá Province
1.89 km from San Francisco
Stay at this aparthotel in Panama City. Enjoy free WiFi, parking (surcharge), and an airport shuttle (surcharge). Popular attractions Albrook Shopping Mall and ...
Megapolis Hotel Panamá

Megapolis Hotel Panamá

5 out of 5
Ave. Balboa al lado de Multicentro, 63 Panama City Panamá Province
2.06 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 4 restaurants. Popular attractions Albrook Shopping Mall and Avenida ...
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
1.99 km from San Francisco
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
15.65 km from San Francisco
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Feb 23 - Wed, Mar 11
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$429 Roundtrip, found 2 days ago
$429
Roundtrip
found 2 days ago
Select Delta flight, departing Mon, Feb 23 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Wed, Mar 11, priced at $429 found 2 days ago
Copa
Mon, Jun 8 - Sun, Jun 14
MIA
Miami Intl.
PTY
Tocumen Intl.
$442 Roundtrip, found 4 days ago
$442
Roundtrip
found 4 days ago
Select Copa flight, departing Mon, Jun 8 from Miami Intl. to Tocumen Intl., returning Sun, Jun 14, priced at $442 found 4 days ago
United
Sun, Feb 22 - Mon, Mar 9
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$444 Roundtrip, found 2 days ago
$444
Roundtrip
found 2 days ago
Select United flight, departing Sun, Feb 22 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Mon, Mar 9, priced at $444 found 2 days ago
avianca
Mon, Jun 8 - Sun, Jun 14
MIA
Miami Intl.
PTY
Tocumen Intl.
$461 Roundtrip, found 4 days ago
$461
Roundtrip
found 4 days ago
Select avianca flight, departing Mon, Jun 8 from Miami Intl. to Tocumen Intl., returning Sun, Jun 14, priced at $461 found 4 days ago
American Airlines
Mon, Jun 8 - Sun, Jun 14
MIA
Miami Intl.
PTY
Tocumen Intl.
$483 Roundtrip, found 4 days ago
$483
Roundtrip
found 4 days ago
Select American Airlines flight, departing Mon, Jun 8 from Miami Intl. to Tocumen Intl., returning Sun, Jun 14, priced at $483 found 4 days ago