San Francisco Vacation Packages for 2025

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San Francisco Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 out of 5
Amador
per person
Jul 15 - Jul 23
found 1 day ago
Roundtrip non-stop flight included
Jacksonville (JAX) to Panama City (PTY)
Stay at this 3.5-star hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
per person
Jul 15 - Jul 23
found 1 day ago
Roundtrip non-stop flight included
Jacksonville (JAX) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
per person
Jul 15 - Jul 23
found 1 day ago
Roundtrip non-stop flight included
Jacksonville (JAX) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Bella Vista
Save 100% on your flight
per person
Jul 15 - Jul 23
found 1 day ago
Roundtrip non-stop flight included
Jacksonville (JAX) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
per person
Jul 15 - Jul 23
found 1 day ago
Roundtrip non-stop flight included
Jacksonville (JAX) to Panama City (PTY)
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

The Sands by Wynwood House

The Sands by Wynwood House

2 out of 5
Calidonia
Save 100% on your flight
per person
Jul 15 - Jul 23
found 1 day ago
Roundtrip non-stop flight included
Jacksonville (JAX) to Panama City (PTY)
Stay at this apartment in Panama City. Enjoy free WiFi and an outdoor pool. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

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Top Hotel Deals

JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
1.9 km from San Francisco
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
Ramada Plaza By Wyndham Panama Punta Pacífica

Ramada Plaza By Wyndham Panama Punta Pacífica

4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
0.58 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
2.31 km from San Francisco
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
2.07 km from San Francisco
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
1.92 km from San Francisco
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
2.01 km from San Francisco
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
0.75 km from San Francisco
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
Aloft Panama

Aloft Panama

3.5 out of 5
Via Israel & Calle 76, Panama City, Panama
0.64 km from San Francisco
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

4 out of 5
CALLE RAMON H JURADO EDIFICO P, Panama City
1.71 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall, Panama City, Panama
1.05 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
San Francisco by Wynwood House

San Francisco by Wynwood House

4 out of 5
C. 73 Este, Panama City, Provincia de Panamá
0.06 km from San Francisco
Stay at this 4-star aparthotel in Panama City. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall ...
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
1.99 km from San Francisco
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
13.34 km from San Francisco
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
15.65 km from San Francisco
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the pool ...
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz, Veracruz, Panama
12.95 km from San Francisco
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, Aug 7 - Mon, Aug 11
MIA
Miami Intl.
PTY
Tocumen Intl.
$266 Roundtrip, found 1 day ago
$266
Roundtrip
found 1 day ago
Select Copa flight, departing Thu, Aug 7 from Miami Intl. to Tocumen Intl., returning Mon, Aug 11, priced at $266 found 1 day ago
Delta
Fri, Jul 11 - Thu, Jul 17
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$283 Roundtrip, found 2 days ago
$283
Roundtrip
found 2 days ago
Select Delta flight, departing Fri, Jul 11 from Fort Lauderdale - Hollywood Intl. to Tocumen Intl., returning Thu, Jul 17, priced at $283 found 2 days ago
Delta
Thu, Aug 14 - Thu, Aug 21
LAX
Los Angeles Intl.
PTY
Tocumen Intl.
$519 Roundtrip, found 6 days ago
$519
Roundtrip
found 6 days ago
Select Delta flight, departing Thu, Aug 14 from Los Angeles Intl. to Tocumen Intl., returning Thu, Aug 21, priced at $519 found 6 days ago
United
Mon, Nov 24 - Thu, Dec 4
EWR
Newark Liberty Intl. Airport
PTY
Tocumen Intl.
$534 Roundtrip, found 3 days ago
$534
Roundtrip
found 3 days ago
Select United flight, departing Mon, Nov 24 from Newark Liberty Intl. Airport to Tocumen Intl., returning Thu, Dec 4, priced at $534 found 3 days ago