San Francisco Vacation Packages for 2025

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Top Hotel Deals

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
2.07 km from San Francisco
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
0.75 km from San Francisco
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
2.31 km from San Francisco
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
1.9 km from San Francisco
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
1.92 km from San Francisco
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
0.58 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
2.01 km from San Francisco
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
Aloft Panama

Aloft Panama

3.5 out of 5
Via Israel & Calle 76, Panama City, Panama
0.64 km from San Francisco
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

4 out of 5
CALLE RAMON H JURADO EDIFICO P, Panama City
1.71 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall, Panama City, Panama
1.05 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
San Francisco by Wynwood House

San Francisco by Wynwood House

3 out of 5
C. 73 Este 12250, Panama City, Provincia de Panamá
0.48 km from San Francisco
Stay at this 3-star aparthotel in Panama City. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall ...
ESHEL SUITES PANAMA

ESHEL SUITES PANAMA

2.5 out of 5
9 C. Tomas Gabriel Duque, Panama City, Panamá Province
1.89 km from San Francisco
Stay at this aparthotel in Panama City. Enjoy free WiFi, parking (surcharge), and an airport shuttle (surcharge). Popular attractions Albrook Shopping Mall and ...
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
1.99 km from San Francisco
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
15.65 km from San Francisco
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
13.34 km from San Francisco
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, Jan 15 - Sun, Jan 25
MIA
Miami Intl.
PTY
Tocumen Intl.
$276 Roundtrip, found 2 days ago
$276
Roundtrip
found 2 days ago
Select Copa flight, departing Thu, Jan 15 from Miami Intl. to Tocumen Intl., returning Sun, Jan 25, priced at $276 found 2 days ago
American Airlines
Mon, Jan 12 - Sat, Jan 24
MIA
Miami Intl.
PTY
Tocumen Intl.
$336 Roundtrip, found 2 days ago
$336
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Jan 12 from Miami Intl. to Tocumen Intl., returning Sat, Jan 24, priced at $336 found 2 days ago
avianca
Thu, Jan 15 - Sun, Jan 25
MIA
Miami Intl.
PTY
Tocumen Intl.
$365 Roundtrip, found 2 days ago
$365
Roundtrip
found 2 days ago
Select avianca flight, departing Thu, Jan 15 from Miami Intl. to Tocumen Intl., returning Sun, Jan 25, priced at $365 found 2 days ago
Delta
Sun, Feb 15 - Thu, Feb 19
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$430 Roundtrip, found 6 days ago
$430
Roundtrip
found 6 days ago
Select Delta flight, departing Sun, Feb 15 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Thu, Feb 19, priced at $430 found 6 days ago
United
Wed, Feb 11 - Fri, Feb 20
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$520 Roundtrip, found 6 days ago
$520
Roundtrip
found 6 days ago
Select United flight, departing Wed, Feb 11 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Fri, Feb 20, priced at $520 found 6 days ago