San Francisco Vacation Packages for 2025

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Top Hotel Deals

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street, Panama City, Panama
0.75 km from San Francisco
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
2.07 km from San Francisco
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
1.9 km from San Francisco
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
2.31 km from San Francisco
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro, Panama City, Panama
2.01 km from San Francisco
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
Ramada Plaza By Wyndham Panama Punta Pacífica

Ramada Plaza By Wyndham Panama Punta Pacífica

4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
0.58 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
1.92 km from San Francisco
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
Aloft Panama

Aloft Panama

3.5 out of 5
Via Israel & Calle 76, Panama City, Panama
0.64 km from San Francisco
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall, Panama City, Panama
1.05 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City

4 out of 5
CALLE RAMON H JURADO EDIFICO P, Panama City
1.71 km from San Francisco
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
San Francisco by Wynwood House

San Francisco by Wynwood House

3.5 out of 5
C. 73 Este 12250, Panama City, Provincia de Panamá
0.48 km from San Francisco
Stay at this 3.5-star aparthotel in Panama City. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping Mall ...
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
1.99 km from San Francisco
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
13.34 km from San Francisco
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
2.53 km from San Francisco
Stay at this 4-star spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
15.65 km from San Francisco
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Sep 10 - Thu, Sep 11
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$198 Roundtrip, found 2 days ago
$198
Roundtrip
found 2 days ago
Select Copa flight, departing Wed, Sep 10 from Juan Santamaría Intl. to Tocumen Intl., returning Thu, Sep 11, priced at $198 found 2 days ago
avianca
Wed, Sep 10 - Thu, Sep 11
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$230 Roundtrip, found 2 days ago
$230
Roundtrip
found 2 days ago
Select avianca flight, departing Wed, Sep 10 from Juan Santamaría Intl. to Tocumen Intl., returning Thu, Sep 11, priced at $230 found 2 days ago
Delta
Wed, Sep 17 - Tue, Sep 23
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$391 Roundtrip, found 22 hours ago
$391
Roundtrip
found 22 hours ago
Select Delta flight, departing Wed, Sep 17 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Tue, Sep 23, priced at $391 found 22 hours ago
American Airlines
Thu, Sep 18 - Sun, Sep 21
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$424 Roundtrip, found 4 days ago
$424
Roundtrip
found 4 days ago
Select American Airlines flight, departing Thu, Sep 18 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Sun, Sep 21, priced at $424 found 4 days ago
United
Wed, Sep 17 - Tue, Sep 23
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$559 Roundtrip, found 22 hours ago
$559
Roundtrip
found 22 hours ago
Select United flight, departing Wed, Sep 17 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Tue, Sep 23, priced at $559 found 22 hours ago