Medical Center District Vacation Packages for 2025

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Top Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
2.3 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
2.88 km from Medical Center District
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road, San Antonio, TX
0.97 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
1.49 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza, San Antonio, TX
12.59 km from Medical Center District
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street, San Antonio, TX
12.29 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive, San Antonio, TX
11.28 km from Medical Center District
Stay at this 3.5-star family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and a lazy river. Our guests praise the pool and the helpful staff ...
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
12.3 km from Medical Center District
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Spark By Hilton San Antonio Northwest near Six Flags

Spark By Hilton San Antonio Northwest near Six Flags

3 out of 5
6755 North Loop 1604 West, San Antonio, TX
10.13 km from Medical Center District
Stay at this 3-star hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the clean rooms in our reviews. Popular attractions ...
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham, San Antonio, TX
12.63 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St, San Antonio, TX
12.28 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham, San Antonio, TX
12.65 km from Medical Center District
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
JW Marriott San Antonio Hill Country Resort & Spa

JW Marriott San Antonio Hill Country Resort & Spa

4.5 out of 5
23808 Resort Pkwy, San Antonio, TX
24.29 km from Medical Center District
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy 4 outdoor pools, a full-service spa, and 6 restaurants. Our guests praise the helpful staff and the ...
La Cantera Resort & Spa

La Cantera Resort & Spa

4 out of 5
16641 La Cantera Pkwy, San Antonio, TX
11.32 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy 5 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff ...
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St, San Antonio, TX
12.1 km from Medical Center District
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Sat, Oct 18 - Sat, Nov 1
LAX
Los Angeles Intl.
SAT
San Antonio Intl.
$92 Roundtrip, found 6 days ago
$92
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Sat, Oct 18 from Los Angeles Intl. to San Antonio Intl., returning Sat, Nov 1, priced at $92 found 6 days ago
Frontier Airlines
Mon, Oct 20 - Thu, Oct 23
ORD
O'Hare Intl.
SAT
San Antonio Intl.
$166 Roundtrip, found 2 days ago
$166
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Mon, Oct 20 from O'Hare Intl. to San Antonio Intl., returning Thu, Oct 23, priced at $166 found 2 days ago
Delta
Thu, Oct 23 - Sat, Oct 25
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$195 Roundtrip, found 4 days ago
$195
Roundtrip
found 4 days ago
Select Delta flight, departing Thu, Oct 23 from Seattle - Tacoma Intl. to San Antonio Intl., returning Sat, Oct 25, priced at $195 found 4 days ago
Hawaiian Airlines
Mon, Oct 20 - Sat, Oct 25
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$237 Roundtrip, found 4 days ago
$237
Roundtrip
found 4 days ago
Select Hawaiian Airlines flight, departing Mon, Oct 20 from Seattle - Tacoma Intl. to San Antonio Intl., returning Sat, Oct 25, priced at $237 found 4 days ago
Alaska Airlines
Tue, Dec 9 - Wed, Dec 10
PDX
Portland Intl.
SAT
San Antonio Intl.
$250 Roundtrip, found 5 days ago
$250
Roundtrip
found 5 days ago
Select Alaska Airlines flight, departing Tue, Dec 9 from Portland Intl. to San Antonio Intl., returning Wed, Dec 10, priced at $250 found 5 days ago