Medical Center District Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
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Medical Center District Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Far West Side
Price was $775, price is now $573 per person
$573
per person
Nov 3 - Nov 8
found 22 hours ago
Roundtrip non-stop flight included
Hartford (BDL) to San Antonio (SAT)
Stay at this 3.5-star family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and a lazy river. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Hill Country Golf Club and Aquatica San Antonio Waterpark are located nearby.
Hyatt Regency Hill Country Resort & Spa
Far West Side
Save 100% on your flight
Price was $1,154, price is now $731 per person
$731
per person
Nov 19 - Nov 24
found 1 day ago
Roundtrip non-stop flight included
Seattle (SEA) to San Antonio (SAT)
Stay at this 4-star eco-certified hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Hill Country Golf Club and Aquatica San Antonio Waterpark are located nearby.
Tapatio Springs Hill Country Resort
Save 100% on your flight
Price was $1,367, price is now $866 per person
$866
per person
Nov 10 - Nov 17
found 1 day ago
Roundtrip non-stop flight included
Roanoke (ROA) to San Antonio (SAT)
Stay at this 4-star golf resort in Boerne. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff in our reviews. Popular attractions Tapatio Springs Golf Club and Albert and Bessie Kronkosky State Natural Area are located nearby.
Plaza San Antonio Hotel & Spa, Autograph Collection
Downtown San Antonio
Save 100% on your flight
Price was $1,038, price is now $764 per person
$764
per person
Nov 11 - Nov 17
found 1 day ago
Roundtrip non-stop flight included
Roanoke (ROA) to San Antonio (SAT)
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions River Walk and Alamo are located nearby.
Tx Home Group- San Antonio
Midtown
Price was $791, price is now $602 per person
$602
per person
Nov 3 - Nov 8
found 22 hours ago
Roundtrip non-stop flight included
Hartford (BDL) to San Antonio (SAT)
Stay at this 3-star guesthouse in San Antonio. Enjoy free WiFi, a fitness center, and laundry facilities. Popular attractions Alamo and River Walk are located nearby.
Landing San Antonio Alamo Ranch Apartments
Far West Side
Price was $846, price is now $647 per person
$647
per person
Nov 10 - Nov 17
found 1 day ago
Roundtrip non-stop flight included
Roanoke (ROA) to San Antonio (SAT)
Stay at this 4-star aparthotel in San Antonio. Enjoy free parking, a fitness center, and in-room washers/dryers. Popular attractions Aquatica San Antonio Waterpark and Hill Country Golf Club are located nearby.
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See all available trips from Columbus to Medical Center District
View all tripsTop Hotel Deals
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd, San Antonio, TX
2.3 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410, San Antonio, TX
2.88 km from Medical Center District
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr, San Antonio, TX
1.49 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Fairfield Inn & Suites by Marriott San Antonio Medical Center
7203 Wurzbach Road, San Antonio, TX
0.97 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hotel Valencia Riverwalk
150 E Houston St, San Antonio, TX
12.1 km from Medical Center District
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Riverwalk Plaza
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
12.3 km from Medical Center District
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street, San Antonio, TX
12.29 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
9700 West Military Drive, San Antonio, TX
11.28 km from Medical Center District
Stay at this 3.5-star family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and a lazy river. Our guests praise the pool and the helpful staff ...
Sonesta ES Suites San Antonio Downtown Alamo Plaza
425 Bonham, San Antonio, TX
12.63 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
303 Blum Street, San Antonio, TX
12.96 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Crockett Hotel
320 Bonham, San Antonio, TX
12.65 km from Medical Center District
Stay at this 3-star historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
Hotel Contessa
306 W Market Street, San Antonio, TX
12.51 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Menger Hotel
204 Alamo Plaza, San Antonio, TX
12.59 km from Medical Center District
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...
Don't see what you're looking for?
See all available properties in Medical Center District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Fri, Dec 5 - Tue, Dec 9
LAX
Los Angeles Intl.
SAT
San Antonio Intl.
$137 Roundtrip, found 1 day ago
$137
Roundtrip
found 1 day ago
Fri, Oct 31 - Fri, Nov 7
ATL
Hartsfield-Jackson Atlanta Intl.
SAT
San Antonio Intl.
$148 Roundtrip, found 1 day ago
$148
Roundtrip
found 1 day ago
Fri, Dec 5 - Tue, Dec 9
LAX
Los Angeles Intl.
SAT
San Antonio Intl.
$159 Roundtrip, found 1 day ago
$159
Roundtrip
found 1 day ago
Fri, Dec 5 - Tue, Dec 9
LAX
Los Angeles Intl.
SAT
San Antonio Intl.
$193 Roundtrip, found 1 day ago
$193
Roundtrip
found 1 day ago
Thu, Apr 2 - Tue, Apr 7
EWR
Newark Liberty Intl. Airport
SAT
San Antonio Intl.
$286 Roundtrip, found 4 days ago
$286
Roundtrip
found 4 days ago