Medical Center District Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Photo by Linda Cronan
Medical Center District Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Far West Side
Price was $690, price is now $478 per person
$478
per person
Feb 9 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Seattle (SEA) to San Antonio (SAT)
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Hill Country Golf Club and Aquatica San Antonio Waterpark are located nearby.
The Gunter Hotel San Antonio Riverwalk
Downtown San Antonio
Save 100% on your flight
Price was $1,089, price is now $696 per person
$696
per person
Jan 24 - Jan 29
found 3 hours ago
Roundtrip non-stop flight included
Seattle (SEA) to San Antonio (SAT)
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Alamo and River Walk are located nearby.
Downtown San Antonio Apartments by Landing
Downtown San Antonio
Save 100% on your flight
Price was $1,316, price is now $915 per person
$915
per person
Feb 9 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Seattle (SEA) to San Antonio (SAT)
Stay at this aparthotel in San Antonio. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions River Walk and Alamo are located nearby.
The Continental, powered by Placemakr - Downtown - Market Square
Downtown San Antonio
Save 100% on your flight
Price was $1,013, price is now $712 per person
$712
per person
Feb 9 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Seattle (SEA) to San Antonio (SAT)
Stay at this apartment in San Antonio. Enjoy free WiFi, laundry facilities, and in-room washers/dryers. Popular attractions River Walk and Alamo are located nearby.
Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG
Northwest Side
Price was $672, price is now $484 per person
$484
per person
Feb 9 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Seattle (SEA) to San Antonio (SAT)
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Six Flags Fiesta Texas and The Shops of La Cantera are located nearby.
Landing South San Antonio
South San Antonio
Save 100% on your flight
Price was $952, price is now $694 per person
$694
per person
Feb 9 - Feb 14
found 1 day ago
Roundtrip non-stop flight included
Seattle (SEA) to San Antonio (SAT)
Stay at this aparthotel in San Antonio. Enjoy free parking, an outdoor pool, and a fitness center. Popular attractions River Walk and Market Square are located nearby.
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See all available trips from Columbus to Medical Center District
View all tripsTop Hotel Deals
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
2.3 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
2.88 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr San Antonio TX
1.49 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
12.1 km from Medical Center District
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Riverwalk Plaza
100 Villita Street San Antonio TX
12.3 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk
303 Blum Street San Antonio TX
12.96 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Hyatt Vacation Club at Wild Oak Ranch, San Antonio
9700 West Military Drive San Antonio TX
11.28 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in ...
Menger Hotel
204 Alamo Plaza San Antonio TX
12.59 km from Medical Center District
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
12.29 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
La Quinta Inn & Suites by Wyndham San Antonio Downtown
100 W. Cesar Chavez Blvd San Antonio TX
12.34 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Sonesta ES Suites San Antonio Downtown Alamo Plaza
425 Bonham San Antonio TX
12.63 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Hotel Contessa
306 W Market Street San Antonio TX
12.51 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Hyatt Regency San Antonio Riverwalk
123 Losoya St San Antonio TX
12.41 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...
Don't see what you're looking for?
See all available properties in Medical Center District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Sat, Feb 21 - Sat, Feb 28
CLT
Charlotte-Douglas Intl.
SAT
San Antonio Intl.
$138 Roundtrip, found 15 hours ago
$138
Roundtrip
found 15 hours ago
Tue, Feb 17 - Sat, Feb 21
CLT
Charlotte-Douglas Intl.
SAT
San Antonio Intl.
$159 Roundtrip, found 15 hours ago
$159
Roundtrip
found 15 hours ago
Sat, Jan 24 - Sat, Feb 7
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$197 Roundtrip, found 2 days ago
$197
Roundtrip
found 2 days ago
Sat, Jan 31 - Sun, Feb 15
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$207 Roundtrip, found 2 days ago
$207
Roundtrip
found 2 days ago
Tue, Jan 27 - Sun, Feb 8
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$215 Roundtrip, found 2 days ago
$215
Roundtrip
found 2 days ago