Medical Center District Vacation Packages for 2026

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Top Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
2.3 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
2.88 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
1.49 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

4 out of 5
105 S Saint Marys Street San Antonio TX
12.29 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
12.64 km from Medical Center District
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham San Antonio TX
12.63 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
12.33 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Hyatt Regency Hill Country Resort and Villas

Hyatt Regency Hill Country Resort and Villas

4 out of 5
9800 Hyatt Resort Dr San Antonio TX
11.32 km from Medical Center District
Book a stay at this golf hotel in San Antonio. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the helpful staff and the clean rooms in ...
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
12.51 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
12.1 km from Medical Center District
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
11.28 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in ...
Kimpton Santo San Antonio - Riverwalk by IHG

Kimpton Santo San Antonio - Riverwalk by IHG

4.5 out of 5
431 South Alamo Street San Antonio TX
12.85 km from Medical Center District
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Popular attractions River Walk and Alamodome are located ...
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St San Antonio TX
12.28 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

2.5 out of 5
143 NE Loop 410 San Antonio TX
9.27 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham San Antonio TX
12.65 km from Medical Center District
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Tue, Jul 21 - Tue, Aug 4
ORD
O'Hare Intl.
SAT
San Antonio Intl.
$200 Roundtrip, found 4 days ago
$200
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Tue, Jul 21 from O'Hare Intl. to San Antonio Intl., returning Tue, Aug 4, priced at $200 found 4 days ago
United
Thu, Aug 20 - Wed, Sep 9
ATL
Hartsfield-Jackson Atlanta Intl.
SAT
San Antonio Intl.
$217 Roundtrip, found 19 hours ago
$217
Roundtrip
found 19 hours ago
Select United flight, departing Thu, Aug 20 from Hartsfield-Jackson Atlanta Intl. to San Antonio Intl., returning Wed, Sep 9, priced at $217 found 19 hours ago
Delta
Sun, Aug 23 - Mon, Aug 31
ATL
Hartsfield-Jackson Atlanta Intl.
SAT
San Antonio Intl.
$237 Roundtrip, found 15 hours ago
$237
Roundtrip
found 15 hours ago
Select Delta flight, departing Sun, Aug 23 from Hartsfield-Jackson Atlanta Intl. to San Antonio Intl., returning Mon, Aug 31, priced at $237 found 15 hours ago
Sun Country Airlines
Thu, Jul 23 - Sat, Aug 1
MSP
Minneapolis - St. Paul Intl.
SAT
San Antonio Intl.
$247 Roundtrip, found 5 days ago
$247
Roundtrip
found 5 days ago
Select Sun Country Airlines flight, departing Thu, Jul 23 from Minneapolis - St. Paul Intl. to San Antonio Intl., returning Sat, Aug 1, priced at $247 found 5 days ago
Southwest Airlines
Thu, Aug 20 - Wed, Sep 9
ATL
Hartsfield-Jackson Atlanta Intl.
SAT
San Antonio Intl.
$273 Roundtrip, found 19 hours ago
$273
Roundtrip
found 19 hours ago
Select Southwest Airlines flight, departing Thu, Aug 20 from Hartsfield-Jackson Atlanta Intl. to San Antonio Intl., returning Wed, Sep 9, priced at $273 found 19 hours ago