Medical Center District Vacation Packages for 2025

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Top Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
2.3 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
2.88 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road San Antonio TX
0.97 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
1.49 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Crockett Hotel

Crockett Hotel

3 out of 5
320 Bonham San Antonio TX
12.65 km from Medical Center District
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
12.1 km from Medical Center District
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
12.3 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
12.29 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
11.28 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and a lazy river. Our guests praise the pool and the helpful staff in ...
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St San Antonio TX
12.28 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street San Antonio TX
12.51 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham San Antonio TX
12.63 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Hyatt Regency San Antonio Riverwalk

Hyatt Regency San Antonio Riverwalk

4 out of 5
123 Losoya St San Antonio TX
12.41 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
12.59 km from Medical Center District
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...
Spark By Hilton San Antonio Northwest near Six Flags

Spark By Hilton San Antonio Northwest near Six Flags

3 out of 5
6755 North Loop 1604 West San Antonio TX
10.13 km from Medical Center District
Stay at this hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the clean rooms in our reviews. Popular attractions ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sat, Jan 3 - Wed, Jan 7
MSP
Minneapolis - St. Paul Intl.
SAT
San Antonio Intl.
$137 Roundtrip, found 6 days ago
$137
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sat, Jan 3 from Minneapolis - St. Paul Intl. to San Antonio Intl., returning Wed, Jan 7, priced at $137 found 6 days ago
Spirit Airlines
Mon, Dec 29 - Wed, Dec 31
LAX
Los Angeles Intl.
SAT
San Antonio Intl.
$174 Roundtrip, found 2 days ago
$174
Roundtrip
found 2 days ago
Select Spirit Airlines flight, departing Mon, Dec 29 from Los Angeles Intl. to San Antonio Intl., returning Wed, Dec 31, priced at $174 found 2 days ago
American Airlines
Fri, Dec 12 - Sun, Dec 14
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$215 Roundtrip, found 3 days ago
$215
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Dec 12 from Seattle - Tacoma Intl. to San Antonio Intl., returning Sun, Dec 14, priced at $215 found 3 days ago
Alaska Airlines
Fri, Dec 12 - Sun, Dec 14
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$217 Roundtrip, found 3 days ago
$217
Roundtrip
found 3 days ago
Select Alaska Airlines flight, departing Fri, Dec 12 from Seattle - Tacoma Intl. to San Antonio Intl., returning Sun, Dec 14, priced at $217 found 3 days ago
United
Fri, Dec 12 - Sun, Dec 14
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$237 Roundtrip, found 3 days ago
$237
Roundtrip
found 3 days ago
Select United flight, departing Fri, Dec 12 from Seattle - Tacoma Intl. to San Antonio Intl., returning Sun, Dec 14, priced at $237 found 3 days ago