South Carolina Midlands Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
South Carolina Midlands Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Paradise Resort
Price was $635, price is now $509 per person
$509
per person
Oct 16 - Oct 20
found 1 day ago
Roundtrip non-stop flight included
Columbus (CMH) to Myrtle Beach (MYR)
Stay at this 3-star beach aparthotel in Myrtle Beach. Enjoy free WiFi, free parking, and a beach locale. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Myrtle Beach Boardwalk and Broadway at the Beach are located nearby.
Marina Inn At Grande Dunes
Save 100% on your flight
Price was $1,168, price is now $802 per person
$802
per person
Oct 16 - Oct 20
found 11 hours ago
Roundtrip non-stop flight included
Columbus (CMH) to Myrtle Beach (MYR)
Stay at this 4.5-star luxury hotel in Myrtle Beach. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Broadway at the Beach and Apache Pier are located nearby.
North Beach Resort & Villas
Windy Hill
Price was $826, price is now $637 per person
$637
per person
Oct 16 - Oct 20
found 1 day ago
Roundtrip non-stop flight included
Columbus (CMH) to Myrtle Beach (MYR)
Stay at this 4-star beach hotel in North Myrtle Beach. Enjoy free WiFi, free parking, and 5 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Barefoot Landing and House of Blues Myrtle Beach are located nearby.
Grande Cayman Resort
Price was $719, price is now $575 per person
$575
per person
Oct 5 - Oct 11
found 15 hours ago
Roundtrip flight included
Detroit (DTW) to Myrtle Beach (MYR)
Stay at this 3-star beach aparthotel in Myrtle Beach. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Broadway at the Beach and Myrtle Beach Boardwalk are located nearby.
Club Wyndham Grand Palms
Price was $746, price is now $599 per person
$599
per person
Oct 5 - Oct 11
found 2 hours ago
Roundtrip flight included
Detroit (DTW) to Myrtle Beach (MYR)
Stay at this 3.5-star condo in Surfside Beach. Enjoy free parking, a lazy river, and in-room washers/dryers. Our guests praise the helpful staff in our reviews. Popular attractions Myrtle Beach State Park and The Market Common are located nearby.
Ocean Villas Beach Resort
Price was $660, price is now $540 per person
$540
per person
Oct 5 - Oct 11
found 16 hours ago
Roundtrip flight included
Detroit (DTW) to Myrtle Beach (MYR)
Stay at this 3-star apartment in Myrtle Beach. Enjoy free parking, an outdoor pool, and laundry facilities. Popular attractions Broadway at the Beach and Myrtle Beach Boardwalk are located nearby.
Don't see what you're looking for?
See all available trips from Columbus to South Carolina Midlands
View all tripsTop Hotel Deals
Hilton Garden Inn Columbia/Harbison
434 Columbiana Dr, Columbia, SC
27.9 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
La Quinta Inn by Wyndham Columbia SE / Fort Jackson
7333 Garners Ferry Rd, Columbia, SC
13.82 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Williams Brice Stadium and Colonial ...
Wyndham Garden Columbia/Ft. Jackson
1539 Horseshoe Dr, Columbia, SC
8 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Cambria Hotel Columbia Downtown The Vista
1000 Lady Street, Columbia, SC
17.89 km from city center
Stay at this 3.5-star business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Sleep Inn Columbia
1901 Rockland Rd, Columbia, SC
24 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
La Quinta Inn by Wyndham Columbia NE/Fort Jackson
1538 Horseshoe Drive, Columbia, SC
7.87 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Park Inn by Radisson Florence, SC
1729 Mandeville Road, Florence, SC
98.94 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Tru By Hilton Columbia Downtown
400 Gervais Street, Building 2, Columbia, SC
18.85 km from city center
Stay at this hotel in Columbia. Enjoy free breakfast, a fitness center, and parking (surcharge). Popular attractions Colonial Life Arena and Riverbanks Zoo and ...
Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG
211 Lanneau Ct, Columbia, SC
27.42 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Courtyard by Marriott Columbia Downtown at USC
630 Assembly St, Columbia, SC
17.88 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
Graduate by Hilton Columbia SC
1619 Pendleton Street, Columbia, SC
16.93 km from city center
Stay at this 4-star business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the bar and ...
Country Inn & Suites by Radisson, Columbia, SC
220 E Exchange Blvd, Columbia, SC
14.09 km from city center
Book a stay at this spa hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
Howard Johnson by Wyndham Florence
2038 W Lucas Street, I-95 Exit 164, Florence, SC
98.97 km from city center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
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See all available properties in South Carolina Midlands
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Sat, Nov 8 - Sat, Nov 15
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$80 Roundtrip, found 2 days ago
$80
Roundtrip
found 2 days ago
Tue, Nov 11 - Wed, Nov 12
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$90 Roundtrip, found 2 days ago
$90
Roundtrip
found 2 days ago
Sat, Nov 8 - Sat, Nov 15
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$139 Roundtrip, found 2 days ago
$139
Roundtrip
found 2 days ago
Sat, Oct 4 - Tue, Oct 7
JFK
John F. Kennedy Intl.
CLT
Charlotte-Douglas Intl.
$139 Roundtrip, found 23 hours ago
$139
Roundtrip
found 23 hours ago
Sat, Nov 8 - Sat, Nov 15
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$139 Roundtrip, found 2 days ago
$139
Roundtrip
found 2 days ago