South Carolina Midlands Vacation Packages for 2025

Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*

Choose two or more items and save on your trip:

South Carolina Midlands Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Sands Ocean Club Resort

Sands Ocean Club Resort

3 out of 5
Save 100% on your flight
Price was $329, price is now $223 per person
$223
per person
Dec 8 - Dec 12
found 1 day ago
Roundtrip flight included
Akron (CAK) to Myrtle Beach (MYR)
Stay at this 3-star beach resort in Myrtle Beach. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the bar in our reviews. Popular attractions Broadway at the Beach and Apache Pier are located nearby.

Marina Inn At Grande Dunes

Marina Inn At Grande Dunes

4.5 out of 5
Save 100% on your flight
Price was $561, price is now $327 per person
$327
per person
Dec 8 - Dec 12
found 1 day ago
Roundtrip flight included
Akron (CAK) to Myrtle Beach (MYR)
Stay at this 4.5-star luxury hotel in Myrtle Beach. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Broadway at the Beach and Apache Pier are located nearby.

Carolina Grande

Carolina Grande

2 out of 5
Save 100% on your flight
Price was $395, price is now $236 per person
$236
per person
Dec 8 - Dec 12
found 1 day ago
Roundtrip flight included
Akron (CAK) to Myrtle Beach (MYR)
Stay at this hotel in Myrtle Beach. Enjoy free WiFi, free parking, and balconies or patios. Popular attractions Broadway at the Beach and Myrtle Beach Boardwalk are located nearby.

Windy Shores II

Windy Shores II

3 out of 5
Windy Hill
Save 100% on your flight
Price was $415, price is now $264 per person
$264
per person
Dec 8 - Dec 12
found 1 day ago
Roundtrip flight included
Akron (CAK) to Myrtle Beach (MYR)
Stay at this 3-star beach condo in North Myrtle Beach. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions House of Blues Myrtle Beach and Barefoot Landing are located nearby.

North Beach Resort & Villas

North Beach Resort & Villas

4 out of 5
Windy Hill
Save 100% on your flight
Price was $542, price is now $371 per person
$371
per person
Dec 8 - Dec 12
found 1 day ago
Roundtrip flight included
Akron (CAK) to Myrtle Beach (MYR)
Stay at this 4-star beach hotel in North Myrtle Beach. Enjoy free WiFi, free parking, and 5 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Barefoot Landing and House of Blues Myrtle Beach are located nearby.

Club Wyndham Ocean Boulevard

Club Wyndham Ocean Boulevard

3.5 out of 5
Ocean Drive
Save 100% on your flight
Price was $415, price is now $294 per person
$294
per person
Dec 8 - Dec 12
found 1 day ago
Roundtrip flight included
Akron (CAK) to Myrtle Beach (MYR)
Stay at this 3.5-star beach hotel in North Myrtle Beach. Enjoy free WiFi, free parking, and 3 outdoor pools. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Cherry Grove Pier and House of Blues Myrtle Beach are located nearby.

Don't see what you're looking for?
See all available trips from Columbus to South Carolina Midlands
View all trips

Top Hotel Deals

Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

3 out of 5
434 Columbiana Dr, Columbia, SC
27.9 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
Sleep Inn Columbia

Sleep Inn Columbia

2.5 out of 5
1901 Rockland Rd, Columbia, SC
24 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Wyndham Garden Columbia/Ft. Jackson

Wyndham Garden Columbia/Ft. Jackson

2.5 out of 5
1539 Horseshoe Dr, Columbia, SC
8 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Country Inn & Suites by Radisson, Columbia, SC

Country Inn & Suites by Radisson, Columbia, SC

2.5 out of 5
220 E Exchange Blvd, Columbia, SC
14.09 km from city center
Book a stay at this spa hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
La Quinta Inn by Wyndham Columbia NE/Fort Jackson

La Quinta Inn by Wyndham Columbia NE/Fort Jackson

3 out of 5
1538 Horseshoe Drive, Columbia, SC
7.87 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Clarion Pointe Near University

Clarion Pointe Near University

2.5 out of 5
1106 N. Anderson Road, Rock Hill, SC
100.34 km from city center
Stay at this hotel in Rock Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Tru By Hilton Columbia Downtown

Tru By Hilton Columbia Downtown

2.5 out of 5
400 Gervais Street, Building 2, Columbia, SC
18.85 km from city center
Stay at this hotel in Columbia. Enjoy free breakfast, a fitness center, and parking (surcharge). Popular attractions Colonial Life Arena and Riverbanks Zoo and ...
Baymont by Wyndham Columbia Fort Jackson

Baymont by Wyndham Columbia Fort Jackson

2.5 out of 5
240 E Exchange Blvd, Columbia, SC
14.14 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road, Florence, SC
98.94 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Cambria Hotel Columbia Downtown The Vista

Cambria Hotel Columbia Downtown The Vista

3.5 out of 5
1000 Lady Street, Columbia, SC
17.89 km from city center
Stay at this 3.5-star business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG

Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG

2.5 out of 5
211 Lanneau Ct, Columbia, SC
27.42 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Courtyard by Marriott Columbia Downtown at USC

Courtyard by Marriott Columbia Downtown at USC

3 out of 5
630 Assembly St, Columbia, SC
17.88 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
Super 8 by Wyndham Harbison/Parkridge Hospital

Super 8 by Wyndham Harbison/Parkridge Hospital

2 out of 5
411 Piney Grove Rd, Columbia, SC
26.3 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Comfort Inn & Suites

Comfort Inn & Suites

2.5 out of 5
527 Woody Jones Blvd, Florence, SC
95.56 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
98.97 km from city center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Don't see what you're looking for?
See all available properties in South Carolina Midlands
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Thu, Nov 13 - Tue, Nov 18
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$65 Roundtrip, found 1 day ago
$65
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Thu, Nov 13 from LaGuardia to Charlotte-Douglas Intl., returning Tue, Nov 18, priced at $65 found 1 day ago
Spirit Airlines
Thu, Nov 13 - Tue, Nov 18
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$70 Roundtrip, found 1 day ago
$70
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Thu, Nov 13 from LaGuardia to Charlotte-Douglas Intl., returning Tue, Nov 18, priced at $70 found 1 day ago
Delta
Mon, Nov 24 - Wed, Dec 3
JFK
John F. Kennedy Intl.
CLT
Charlotte-Douglas Intl.
$174 Roundtrip, found 3 days ago
$174
Roundtrip
found 3 days ago
Select Delta flight, departing Mon, Nov 24 from John F. Kennedy Intl. to Charlotte-Douglas Intl., returning Wed, Dec 3, priced at $174 found 3 days ago
American Airlines
Wed, Dec 3 - Sun, Dec 7
DFW
Dallas-Fort Worth Intl.
CLT
Charlotte-Douglas Intl.
$190 Roundtrip, found 2 days ago
$190
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Dec 3 from Dallas-Fort Worth Intl. to Charlotte-Douglas Intl., returning Sun, Dec 7, priced at $190 found 2 days ago
United
Wed, Dec 17 - Sun, Dec 28
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$234 Roundtrip, found 3 hours ago
$234
Roundtrip
found 3 hours ago
Select United flight, departing Wed, Dec 17 from Newark Liberty Intl. Airport to Charlotte-Douglas Intl., returning Sun, Dec 28, priced at $234 found 3 hours ago