
South Carolina Midlands Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Top Hotel Deals

Hilton Garden Inn Columbia/Harbison
434 Columbiana Dr Columbia SC
27.9 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...

Howard Johnson by Wyndham Florence
2038 W Lucas Street Florence SC
98.97 km from city center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Sleep Inn Columbia
1901 Rockland Rd Columbia SC
24 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...

Park Inn by Radisson Florence, SC
1729 Mandeville Road Florence SC
98.94 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...

Courtyard by Marriott Columbia Downtown at USC
630 Assembly St Columbia SC
17.88 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...

La Quinta Inn by Wyndham Columbia SE / Fort Jackson
7333 Garners Ferry Rd Columbia SC
13.82 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Millwood Plantation Ruins and ...

Country Inn & Suites by Radisson, Columbia, SC
220 E Exchange Blvd Columbia SC
14.09 km from city center
Book a stay at this spa hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...

Tru By Hilton Columbia Downtown
400 Gervais Street Columbia SC
18.85 km from city center
Stay at this hotel in Columbia. Enjoy free breakfast, a fitness center, and parking (surcharge). Popular attractions Riverbanks Zoo and Garden and EdVenture ...

Graduate by Hilton Columbia SC
1619 Pendleton Street Columbia SC
16.93 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...

Hyatt Place Columbia/Downtown/The Vista
819 Gervais Street Columbia SC
18.16 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

Wyndham Garden Columbia/Ft. Jackson
1539 Horseshoe Dr Columbia SC
8 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Motel 6 West Columbia, SC - Airport
650 Cherokee Lane West Columbia SC
24.65 km from city center
Book a stay at this business-friendly motel in West Columbia. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and ...

Clarion Pointe Rock Hill Near University
1106 N. Anderson Road Rock Hill SC
100.34 km from city center
Stay at this hotel in Rock Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
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See all available properties in South Carolina Midlands
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sun, May 24 - Sun, Jun 14
PHL
Philadelphia Intl.
CLT
Charlotte-Douglas Intl.
$149 Roundtrip, found 2 days ago
$149
Roundtrip
found 2 days ago

Tue, Jun 2 - Tue, Jun 9
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$168 Roundtrip, found 5 days ago
$168
Roundtrip
found 5 days ago

Sat, Jul 4 - Tue, Jul 7
LGA
LaGuardia
CAE
Columbia Metropolitan
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago

Sat, Jul 4 - Tue, Jul 7
LGA
LaGuardia
CAE
Columbia Metropolitan
$259 Roundtrip, found 1 day ago
$259
Roundtrip
found 1 day ago

Wed, Jun 3 - Tue, Jun 9
EWR
Newark Liberty Intl. Airport
CAE
Columbia Metropolitan
$269 Roundtrip, found 1 day ago
$269
Roundtrip
found 1 day ago

