South Carolina Midlands Vacation Packages for 2025

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South Carolina Midlands Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Sands Ocean Club Resort

Sands Ocean Club Resort

3 out of 5
Save 100% on your flight
per person
Sep 4 - Sep 8
found 1 day ago
Roundtrip flight included
New York (LGA) to Myrtle Beach (MYR)
Stay at this 3-star beach resort in Myrtle Beach. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the bar in our reviews. Popular attractions Broadway at the Beach and Apache Pier are located nearby.

Sands Beach Club

Sands Beach Club

2.5 out of 5
Save 100% on your flight
per person
Sep 4 - Sep 8
found 1 day ago
Roundtrip flight included
New York (LGA) to Myrtle Beach (MYR)
Stay at this vacation home in Myrtle Beach. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Broadway at the Beach and Apache Pier are located nearby.

Marina Inn At Grande Dunes

Marina Inn At Grande Dunes

4.5 out of 5
Save 100% on your flight
per person
Sep 19 - Sep 23
found 1 day ago
Roundtrip flight included
Detroit (DTW) to Myrtle Beach (MYR)
Stay at this 4.5-star luxury hotel in Myrtle Beach. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Broadway at the Beach and Apache Pier are located nearby.

Hilton Garden Inn Charlotte Pineville

Hilton Garden Inn Charlotte Pineville

3 out of 5
Save 100% on your flight
per person
Sep 23 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Charlotte (CLT)
Stay at this 3-star business-friendly hotel in Pineville. Enjoy free parking, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff in our reviews. Popular attractions Carowinds Theme Park and Quail Hollow Club are located nearby.

Wingate by Wyndham Charlotte Airport I-85/I-485

Wingate by Wyndham Charlotte Airport I-85/I-485

2.5 out of 5
Save 100% on your flight
per person
Sep 23 - Sep 28
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to Charlotte (CLT)
Book a stay at this business-friendly hotel in Charlotte. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Bank of America Stadium and Spectrum Center are located nearby.

Dunes Village Resort

Dunes Village Resort

3.5 out of 5
Save 100% on your flight
per person
Sep 4 - Sep 8
found 1 day ago
Roundtrip flight included
New York (LGA) to Myrtle Beach (MYR)
Stay at this 3.5-star beach aparthotel in Myrtle Beach. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the pool and the bar in our reviews. Popular attractions Broadway at the Beach and Myrtle Beach Boardwalk are located nearby.

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Top Hotel Deals

Tru By Hilton Columbia Downtown

Tru By Hilton Columbia Downtown

2.5 out of 5
400 Gervais Street, Building 2, Columbia, SC
18.85 km from city center
Stay at this hotel in Columbia. Enjoy free breakfast, a fitness center, and parking (surcharge). Popular attractions Riverbanks Zoo and Garden and Williams Brice ...
Hilton Garden Inn Columbia/Harbison

Hilton Garden Inn Columbia/Harbison

3 out of 5
434 Columbiana Dr, Columbia, SC
27.9 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
La Quinta Inn by Wyndham Columbia SE / Fort Jackson

La Quinta Inn by Wyndham Columbia SE / Fort Jackson

3 out of 5
7333 Garners Ferry Rd, Columbia, SC
13.82 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Williams Brice Stadium and Millwood ...
Clarion Pointe Near University

Clarion Pointe Near University

2.5 out of 5
1106 N. Anderson Road, Rock Hill, SC
100.37 km from city center
Stay at this hotel in Rock Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Wyndham Garden Columbia/Ft. Jackson

Wyndham Garden Columbia/Ft. Jackson

2.5 out of 5
1539 Horseshoe Dr, Columbia, SC
8 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free parking, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Comfort Inn & Suites

Comfort Inn & Suites

2.5 out of 5
527 Woody Jones Blvd, Florence, SC
95.06 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Howard Johnson by Wyndham Florence

Howard Johnson by Wyndham Florence

2 out of 5
2038 W Lucas Street, I-95 Exit 164, Florence, SC
98.97 km from city center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Park Inn by Radisson Florence, SC

Park Inn by Radisson Florence, SC

2.5 out of 5
1729 Mandeville Road, Florence, SC
98.94 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Baymont by Wyndham Columbia Fort Jackson

Baymont by Wyndham Columbia Fort Jackson

2.5 out of 5
240 E Exchange Blvd, Columbia, SC
14.14 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
La Quinta Inn by Wyndham Columbia NE/Fort Jackson

La Quinta Inn by Wyndham Columbia NE/Fort Jackson

3 out of 5
1538 Horseshoe Drive, Columbia, SC
7.87 km from city center
Stay at this 3-star business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Cambria Hotel Columbia Downtown The Vista

Cambria Hotel Columbia Downtown The Vista

3.5 out of 5
1000 Lady Street, Columbia, SC
17.89 km from city center
Stay at this 3.5-star business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
La Quinta Inn & Suites by Wyndham Rock Hill

La Quinta Inn & Suites by Wyndham Rock Hill

3 out of 5
1235 Springdale Rd, Rock Hill, SC
96.7 km from city center
Stay at this 3-star business-friendly hotel in Rock Hill. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hyatt Place Columbia/Harbison

Hyatt Place Columbia/Harbison

3 out of 5
1130 Kinley Road, Irmo, SC
27.82 km from city center
Stay at this 3-star business-friendly hotel in Irmo. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful staff ...
Graduate by Hilton Columbia SC

Graduate by Hilton Columbia SC

4 out of 5
1619 Pendleton Street, Columbia, SC
16.93 km from city center
Stay at this 4-star business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the bar and ...
Quality Inn Columbia Airport

Quality Inn Columbia Airport

2.5 out of 5
2516 Augusta Rd, West Columbia, SC
24.38 km from city center
Stay at this hotel in West Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Tue, Oct 21 - Wed, Oct 22
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$70 Roundtrip, found 4 hours ago
$70
Roundtrip
found 4 hours ago
Select Spirit Airlines flight, departing Tue, Oct 21 from LaGuardia to Charlotte-Douglas Intl., returning Wed, Oct 22, priced at $70 found 4 hours ago
Frontier Airlines
Wed, Aug 13 - Tue, Aug 19
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$91 Roundtrip, found 6 days ago
$91
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Wed, Aug 13 from LaGuardia to Charlotte-Douglas Intl., returning Tue, Aug 19, priced at $91 found 6 days ago
American Airlines
Wed, Aug 13 - Tue, Aug 19
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$139 Roundtrip, found 6 days ago
$139
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Aug 13 from LaGuardia to Charlotte-Douglas Intl., returning Tue, Aug 19, priced at $139 found 6 days ago
Delta
Tue, Oct 7 - Sat, Oct 11
LGA
LaGuardia
CAE
Columbia Metropolitan
$157 Roundtrip, found 6 days ago
$157
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, Oct 7 from LaGuardia to Columbia Metropolitan, returning Sat, Oct 11, priced at $157 found 6 days ago
United
Wed, Aug 20 - Thu, Aug 21
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$167 Roundtrip, found 2 days ago
$167
Roundtrip
found 2 days ago
Select United flight, departing Wed, Aug 20 from Newark Liberty Intl. Airport to Charlotte-Douglas Intl., returning Thu, Aug 21, priced at $167 found 2 days ago