South Carolina Midlands Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
South Carolina Midlands Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Sleep Inn Columbia
Seven Oaks
Price was $595, price is now $426 per person
$426
per person
Apr 8 - Apr 14
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Columbia (CAE)
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Riverbanks Zoo and Garden and BTM Dutch Square Cinema 14 are located nearby.
North Beach Resort & Villas
Windy Hill
Save 100% on your flight
Price was $1,777, price is now $1,104 per person
$1,104
per person
Mar 29 - Apr 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Myrtle Beach (MYR)
Book a stay at this beach hotel in North Myrtle Beach. Enjoy free WiFi, free parking, and 5 outdoor pools. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Barefoot Landing and House of Blues Myrtle Beach are located nearby.
Sands Ocean Club Resort
Price was $986, price is now $660 per person
$660
per person
Mar 29 - Apr 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Myrtle Beach (MYR)
Book a stay at this beach resort in Myrtle Beach. Enjoy free WiFi, free parking, and an outdoor pool. Our guests praise the pool and the bar in our reviews. Popular attractions Apache Pier and Barefoot Landing are located nearby.
Embassy Suites by Hilton Myrtle Beach Oceanfront Resort
Price was $1,228, price is now $854 per person
$854
per person
Mar 29 - Apr 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Myrtle Beach (MYR)
Book a stay at this beach resort in Myrtle Beach. Enjoy free breakfast, free WiFi, and 7 outdoor pools. Our guests praise the breakfast and the pool in our reviews. Popular attractions Apache Pier and Barefoot Landing are located nearby.
Courtyard by Marriott Columbia Downtown at USC
Downtown Columbia
Save 100% on your flight
Price was $1,243, price is now $885 per person
$885
per person
Apr 8 - Apr 14
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Columbia (CAE)
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Riverbanks Zoo and Garden and Carolina Coliseum are located nearby.
Crown Reef Beach Resort and Waterpark
Price was $1,240, price is now $886 per person
$886
per person
Mar 29 - Apr 4
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to Myrtle Beach (MYR)
Book a stay at this beach aparthotel in Myrtle Beach. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Myrtle Beach Boardwalk and Myrtle Beach State Park are located nearby.
Don't see what you're looking for?
See all available trips from Columbus to South Carolina Midlands
View all tripsTop Hotel Deals
Hilton Garden Inn Columbia/Harbison
434 Columbiana Dr Columbia SC
27.9 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
La Quinta Inn by Wyndham Columbia SE / Fort Jackson
7333 Garners Ferry Rd Columbia SC
13.82 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Millwood Plantation Ruins and ...
Graduate by Hilton Columbia SC
1619 Pendleton Street Columbia SC
16.93 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Courtyard by Marriott Columbia Downtown at USC
630 Assembly St Columbia SC
17.88 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, an outdoor pool, and breakfast (surcharge). Our guests praise the helpful staff and ...
Park Inn by Radisson Florence, SC
1729 Mandeville Road Florence SC
98.94 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and the ...
Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG
211 Lanneau Ct Columbia SC
27.42 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
La Quinta Inn by Wyndham Columbia NE/Fort Jackson
1538 Horseshoe Drive Columbia SC
7.87 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Cambria Hotel Columbia Downtown The Vista
1000 Lady Street Columbia SC
17.89 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Howard Johnson by Wyndham Florence
2038 W Lucas Street Florence SC
98.97 km from city center
Book a stay at this business-friendly motel in Florence. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Comfort Inn & Suites Florence Center Area
527 Woody Jones Blvd Florence SC
95.56 km from city center
Book a stay at this business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
Tru By Hilton Columbia Downtown
400 Gervais Street Columbia SC
18.85 km from city center
Stay at this hotel in Columbia. Enjoy free breakfast, a fitness center, and parking (surcharge). Popular attractions Riverbanks Zoo and Garden and EdVenture ...
Hyatt Place Columbia/Downtown/The Vista
819 Gervais Street Columbia SC
18.16 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Sleep Inn Columbia
1901 Rockland Rd Columbia SC
24 km from city center
Book a stay at this business-friendly hotel in Columbia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Don't see what you're looking for?
See all available properties in South Carolina Midlands
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Thu, Feb 26 - Sat, Feb 28
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$68 Roundtrip, found 18 hours ago
$68
Roundtrip
found 18 hours ago
Sat, Feb 21 - Wed, Feb 25
LGA
LaGuardia
CLT
Charlotte-Douglas Intl.
$82 Roundtrip, found 18 hours ago
$82
Roundtrip
found 18 hours ago
Sat, Feb 28 - Tue, Mar 3
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$159 Roundtrip, found 13 hours ago
$159
Roundtrip
found 13 hours ago
Sat, Feb 28 - Tue, Mar 3
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$159 Roundtrip, found 13 hours ago
$159
Roundtrip
found 13 hours ago
Sat, Feb 28 - Tue, Mar 3
EWR
Newark Liberty Intl. Airport
CLT
Charlotte-Douglas Intl.
$179 Roundtrip, found 13 hours ago
$179
Roundtrip
found 13 hours ago