San Antonio Vacation Packages for 2025

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San Antonio Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 out of 5
Amador
per person
Jul 19 - Jul 26
found 19 hours ago
Roundtrip non-stop flight included
Philadelphia (PHL) to Panama City (PTY)
Stay at this 3.5-star hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
per person
Jul 19 - Jul 26
found 19 hours ago
Roundtrip non-stop flight included
Philadelphia (PHL) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
per person
Jul 19 - Jul 26
found 19 hours ago
Roundtrip non-stop flight included
Philadelphia (PHL) to Panama City (PTY)
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
per person
Jul 19 - Jul 26
found 19 hours ago
Roundtrip non-stop flight included
Philadelphia (PHL) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

The Beach House

The Beach House

3 out of 5
Amador
per person
Jul 19 - Jul 26
found 19 hours ago
Roundtrip non-stop flight included
Philadelphia (PHL) to Panama City (PTY)
Stay at this 3-star hotel in Panama City. Enjoy free WiFi, free parking, and a beach locale. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

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Top Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
12.43 km from San Antonio
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
23.79 km from San Antonio
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
6.06 km from San Antonio
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the breakfast and the pool ...
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica, Panama City, Panama
11.98 km from San Antonio
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz, Veracruz, Panama
23.39 km from San Antonio
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111, Panama City, Panama
12.8 km from San Antonio
Stay at this 4-star spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla, Winston Churchill Street, Panama City, Panama
12.71 km from San Antonio
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
Riande Urban Hotel

Riande Urban Hotel

3.5 out of 5
El Cangrejo; Calle Eusebio A, Morales, Panama City, Panama
12.37 km from San Antonio
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and 2 restaurants. Our guests praise the bar and the helpful staff ...
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall, Panama City, Panama
15.78 km from San Antonio
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa, Panama City
12.53 km from San Antonio
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons, El Cangre, Bella Vista, Panama City, Panama
11.9 km from San Antonio
Stay at this 4-star family-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina, Panama City, Panama
12.22 km from San Antonio
Stay at this 3-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
TRYP by Wyndham Panamá Centro

TRYP by Wyndham Panamá Centro

3.5 out of 5
Via Veneto, El Cangrejo Bellavista, Panama City, Panama
12.74 km from San Antonio
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a rooftop terrace. Our guests praise the helpful staff and the ...
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53, Paitilla, Panama City, Panama
12.37 km from San Antonio
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
Ramada Plaza By Wyndham Panama Punta Pacífica

Ramada Plaza By Wyndham Panama Punta Pacífica

4 out of 5
Via Israel y Calle 71, San Francisco, Panama City, Panama
10.94 km from San Antonio
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Sun, Mar 22 - Sat, Mar 28
MIA
Miami Intl.
PTY
Tocumen Intl.
$376 Roundtrip, found 1 day ago
$376
Roundtrip
found 1 day ago
Select avianca flight, departing Sun, Mar 22 from Miami Intl. to Tocumen Intl., returning Sat, Mar 28, priced at $376 found 1 day ago
Delta
Fri, Jun 27 - Sat, Jun 28
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$397 Roundtrip, found 4 days ago
$397
Roundtrip
found 4 days ago
Select Delta flight, departing Fri, Jun 27 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Sat, Jun 28, priced at $397 found 4 days ago
United
Sun, Jun 1 - Tue, Jun 10
EWR
Newark Liberty Intl. Airport
PTY
Tocumen Intl.
$489 Roundtrip, found 5 days ago
$489
Roundtrip
found 5 days ago
Select United flight, departing Sun, Jun 1 from Newark Liberty Intl. Airport to Tocumen Intl., returning Tue, Jun 10, priced at $489 found 5 days ago
avianca
Sun, Jun 1 - Tue, Jun 10
JFK
John F. Kennedy Intl.
PTY
Tocumen Intl.
$489 Roundtrip, found 5 days ago
$489
Roundtrip
found 5 days ago
Select avianca flight, departing Sun, Jun 1 from John F. Kennedy Intl. to Tocumen Intl., returning Tue, Jun 10, priced at $489 found 5 days ago