San Antonio Vacation Packages for 2026

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Top Hotel Deals

Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4 out of 5
Avenida Domingo Diaz via Tocumen San Miguelito Panama
1.38 km from San Antonio
Book a stay at this business-friendly hotel in San Miguelito. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
12.43 km from San Antonio
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
6.06 km from San Antonio
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
The Executive Hotel

The Executive Hotel

3.5 out of 5
Calle 52 Panama City Panama
12.82 km from San Antonio
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
12.22 km from San Antonio
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
23.79 km from San Antonio
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
12.71 km from San Antonio
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Calle 52 and Ricardo Arias Panama City
12.78 km from San Antonio
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Albrook Shopping Mall and Avenida ...
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 out of 5
Amador Avenue & Van Hook Street Panama City Panama
18.3 km from San Antonio
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff and the property condition ...
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
12.74 km from San Antonio
Book a stay at this spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Avenida Balboa are ...
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
11.51 km from San Antonio
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
Hotel Ojos del Rio

Hotel Ojos del Rio

3.5 out of 5
calle 41 este Panama City Panama
13.91 km from San Antonio
Stay at this hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
12.01 km from San Antonio
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
13.12 km from San Antonio
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Novotel Panama City

Novotel Panama City

4 out of 5
Calle Jose I. Fabrega y Thais de Pons Panama City Panama
11.9 km from San Antonio
Book a stay at this family-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Jul 1 - Sun, Jul 5
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$275 Roundtrip, found 3 days ago
$275
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Jul 1 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Jul 5, priced at $275 found 3 days ago
avianca
Wed, Jul 1 - Sun, Jul 5
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$300 Roundtrip, found 3 days ago
$300
Roundtrip
found 3 days ago
Select avianca flight, departing Wed, Jul 1 from Juan Santamaría Intl. to Tocumen Intl., returning Sun, Jul 5, priced at $300 found 3 days ago
American Airlines
Mon, Oct 26 - Sun, Nov 1
MIA
Miami Intl.
PTY
Tocumen Intl.
$417 Roundtrip, found 3 days ago
$417
Roundtrip
found 3 days ago
Select American Airlines flight, departing Mon, Oct 26 from Miami Intl. to Tocumen Intl., returning Sun, Nov 1, priced at $417 found 3 days ago
United
Fri, May 15 - Fri, Jun 5
MIA
Miami Intl.
PTY
Tocumen Intl.
$453 Roundtrip, found 2 days ago
$453
Roundtrip
found 2 days ago
Select United flight, departing Fri, May 15 from Miami Intl. to Tocumen Intl., returning Fri, Jun 5, priced at $453 found 2 days ago
Delta
Mon, Aug 31 - Thu, Sep 3
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$596 Roundtrip, found 1 day ago
$596
Roundtrip
found 1 day ago
Select Delta flight, departing Mon, Aug 31 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Thu, Sep 3, priced at $596 found 1 day ago