A city square with a fountain, modern buildings, and a historic tower.

Boutique Hotels in Missouri

Check availability on Missouri Boutique Hotels

Our top choices for Missouri boutique hotels

A modern lobby with a staircase, seating area, and wall-mounted artwork.

1. Moonrise Hotel

Moonrise Hotel
4.0 star property
Delmar Loop
9.0 out of 10, Wonderful, (2,059 reviews)
"Cool hotel!"
United States
Rebecca
Moonrise Hotel
A cozy lounge area with leather sofas, a fireplace, and a bar counter.

2. The Cheshire

The Cheshire
4.0 star property
Richmond Heights
8.8 out of 10, Excellent, (1,008 reviews)
"Fantastic hotel, clean and nice rooms, great breakfast and location"
United States
Matthew
The Cheshire
A traditional Tudor-style building with a black awning labeled "28 Sally's Inn."

3. Seven Gables, St. Louis West, a Tribute Portfolio Hotel

Seven Gables, St. Louis West, a Tribute Portfolio Hotel
3.5 star property
Clayton
8.4 out of 10, Very good, (603 reviews)
"I always stay at the Seven Gables Inn while visiting St. Louis - fantastic, walkable neighborhood, for central STL, including vintage shopping & dining options. The boutique hotel is very ‘Old St. Louis’ with extremely modern, comfortable, quiet and safe rooms."
United States
Jennifer
Seven Gables, St. Louis West, a Tribute Portfolio Hotel
A luxurious lobby with a grand chandelier, plush seating, and a polished floor.

4. Ambassador Hotel Kansas City, Autograph Collection

Ambassador Hotel Kansas City, Autograph Collection
4.5 star property
Downtown Kansas City
9.2 out of 10, Wonderful, (834 reviews)
"My wife and I loved our stay. It was a one-night birthday getaway (we live in the surrounding Metro area), and we wanted an upscale night out with a high-end dining experience right on site. The staff was wonderful, the parking was easy, the property was magnificent, and the restaurant (American Reserve) was top shelf. I'm so grateful we stayed here."
United States
Kyle
Ambassador Hotel Kansas City, Autograph Collection
A spacious lobby with a grand staircase, a statue, a seating area with green sofas, and a well-lit reading area with bookshelves.

5. Hotel Phillips Kansas City Curio Collection by Hilton

Hotel Phillips Kansas City Curio Collection by Hilton
4.0 star property
Downtown Kansas City
8.6 out of 10, Excellent, (1,034 reviews)
"We had a great stay! Centrally located to the downtown area, lots of food options, very well maintained facility, and we had a great time!"
United States
Tim
Hotel Phillips Kansas City Curio Collection by Hilton
A grand lobby with a large TV screen, a chandelier, and a blue sofa.

6. voco The Tiger Hotel Columbia, MO by IHG

voco The Tiger Hotel Columbia, MO by IHG
4.0 star property
Columbia
9.0 out of 10, Wonderful, (1,000 reviews)
"Great location. Has restaurant and bar on first floor that were great."
United States
lance
voco The Tiger Hotel Columbia, MO by IHG
A hotel entrance with a brick facade, a fountain, and decorative lights.

7. The Raphael Hotel, Autograph Collection

The Raphael Hotel, Autograph Collection
4.0 star property
South Plaza
9.6 out of 10, Exceptional, (1,000 reviews)
"Best hotel ive stayed in"
United States
Jose
The Raphael Hotel, Autograph Collection
A modern living room with a large painting, leather sofa, and decorative pillows.

8. The Fontaine

The Fontaine
4.5 star property
West Plaza
9.0 out of 10, Wonderful, (1,073 reviews)
"I have stayed there a few times and will be continuing to come back there when I'm in Kansas City."
United States
Melissa
The Fontaine
A revolving door with glass panels, two potted plants, and signage for 'MERIDEN' and 'VALET'.

9. Le Meridien St. Louis Downtown

Le Meridien St. Louis Downtown
4.0 star property
Downtown St. Louis
6.4 out of 10, (5 reviews)
Le Meridien St. Louis Downtown
A grand lobby with a large chandelier, a bar area, and classical architecture.

10. Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
4.0 star property
Downtown St. Louis
8.6 out of 10, Excellent, (1,410 reviews)
"Gorgeous historic hotel close to all main downtown sightseeings."
United States
Anastasia
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Missouri Hotel Reviews

Explore a world of travel with Expedia