Luxury Hotels in Missouri
Check availability on Missouri Luxury Hotels
Pick from 414 Missouri Luxury Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

The Royal Sonesta Chase Park Plaza St. Louis
The Royal Sonesta Chase Park Plaza St. Louis
9.0 out of 10, Wonderful, (1011)

Ameristar Casino Resort and Spa
Ameristar Casino Resort and Spa
8.4 out of 10, Very Good, (1002)

The Ritz-Carlton, St. Louis
The Ritz-Carlton, St. Louis
9.2 out of 10, Wonderful, (538)

Four Seasons Hotel St Louis
Four Seasons Hotel St Louis
9.4 out of 10, Exceptional, (1002)

Moberly Inn and Suites
Moberly Inn and Suites
5.0 out of 10, (172)

Clayton Plaza Hotel & Extended Stay
Clayton Plaza Hotel & Extended Stay
8.8 out of 10, Excellent, (2928)

The Westin St. Louis
The Westin St. Louis
8.6 out of 10, Excellent, (1004)

Cliffs Resort Table Rock Lake
Cliffs Resort Table Rock Lake
9.2 out of 10, Wonderful, (967)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Top destinations for Luxury Hotels in Missouri
More Hotel Options in Missouri
- Hotels with Air Conditioning in Missouri
- Hotels with WiFi in Missouri
- Family Hotels in Missouri
- Hotel with wifi in Missouri
- Hotels with a Pool in Missouri
- Hotels with Complimentary Breakfast in Missouri
- Smoke Free Hotels in Missouri
- Pet-friendly Hotels in Missouri
- Cheap Hotels in Missouri
- Hotels with Hot Tubs in Missouri
- Hotels with an Indoor Pool in Missouri
- Hotels with Bars in Missouri
- Resorts & Hotels with Spas in Missouri
- Hotels with Balconies in Missouri
More Themes
- Hotels with Air Conditioning
- All-inclusive Hotel
- Hotels with Balconies
- Hotels with Bars
- Beach Hotels
- Boutique Hotels
- Cheap Hotels
- Business Hotels
- Casinos
- Hotel with a Concierge
- Hotels with Restaurants
- Family Hotels
- Hotels with Fireplaces
- Hotels with a Fitness Center
- Hotels with Free Airport Shuttle
- Hotels with Complimentary Breakfast
- Hotels with Free Parking
- Hotel with wifi
- Golf Hotels
- Historic Hotels
- Hotels with Hot Tubs
- Hotels with an Indoor Pool
- Apartment Hotel
- Hotels with a Kitchen
- Lakefront Hotels
- Hotels with a Lazy River
- Gay friendly Hotels
- Smoke Free Hotels
- Oceanfront Hotels
- Pet-friendly Hotels
- Hotels with a Pool
- Adventure Hotels
- Hotels on the River
- Romantic Hotels
- Hotels with Room Service
- Secluded Hotels
- Shopping Hotels
- Ski Hotels
- Hotels with smoking rooms
- Resorts & Hotels with Spas
- Hotels with Suites
- Green Hotels
- Hotels with Tennis Courts
- Waterpark Hotels
- Hotels with Waterslides
- Hotel Wedding Venues
- Hotels with WiFi
- Winery Hotels
Stay near popular Missouri attractions
Discover hotels close to Missouri with room rates, reviews, and availability. Most hotels are fully refundable.
- Thousand Hills Resort Hotel
- Hyatt Regency St. Louis at The Arch
- Drury Plaza Hotel St. Louis at the Arch
- Clayton Plaza Hotel & Extended Stay
- The Arch Convention Hotel
- Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
- The Stone Castle Hotel & Conference Center
- Hyatt Vacation Club at The Lodges at Timber Ridge, Branson
- Hotel Grand Victorian
- Loews Kansas City Hotel