2026 2 Star Hotels in Otay Mesa

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Featured Otay Mesa 2 Star Hotels

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place San Diego CA
Fully refundableReserve now, pay when you stay
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area
Heritage Inn San Diego

Heritage Inn San Diego

2 out of 5
3333 Channel Way San Diego CA
Fully refundable
Heritage Inn San Diego
Kings Inn San Diego

Kings Inn San Diego

2.5 out of 5
1333 Hotel Cir S San Diego CA
Fully refundableReserve now, pay when you stay
Kings Inn San Diego
Hampton Inn San Diego-Downtown

Hampton Inn San Diego-Downtown

2.5 out of 5
San Diego CA
Fully refundableReserve now, pay when you stay
Hampton Inn San Diego-Downtown
Ash&9th

Ash&9th

2 out of 5
833 Ash Street San Diego CA
Fully refundableReserve now, pay when you stay
Ash&9th
Holiday Inn Express San Diego Downtown by IHG

Holiday Inn Express San Diego Downtown by IHG

2.5 out of 5
1430 7th Ave San Diego CA
Fully refundable
Holiday Inn Express San Diego Downtown by IHG
Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista

2 out of 5
230 Broadway Chula Vista CA
Fully refundableReserve now, pay when you stay
Hotel Palmeras Chula Vista
Motel 6 El Cajon, CA - San Diego

Motel 6 El Cajon, CA - San Diego

2 out of 5
550 Montrose Court El Cajon CA
Motel 6 El Cajon, CA - San Diego
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

2.5 out of 5
2151 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
Hampton Inn San Diego/Mission Valley
See all 4,877 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.