2026 3 Star Hotels in Otay Mesa

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Featured Otay Mesa 3 Star Hotels

Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
Best Western Seven Seas
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
Fully refundableReserve now, pay when you stay
Handlery Hotel
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
The Sofia Hotel
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundable
The DEXTRO Little Italy, BW Premier Collection
Comfort Inn San Diego Airport At The Harbor

Comfort Inn San Diego Airport At The Harbor

3.5 out of 5
San Diego CA
Comfort Inn San Diego Airport At The Harbor
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
The Dana on Mission Bay
Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld

3 out of 5
3737 Sports Arena Blvd San Diego CA
Wyndham Garden San Diego Near SeaWorld
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Days Inn by Wyndham San Diego Hotel Circle
Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG

3.5 out of 5
2270 Hotel Cir N San Diego CA
Fully refundable
Crowne Plaza San Diego - Mission Valley by IHG
See all 4,911 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.