2026 4 Star Hotels in Otay Mesa

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Featured Otay Mesa 4 Star Hotels

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
Manchester Grand Hyatt San Diego
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr San Diego CA
Fully refundableReserve now, pay when you stay
San Diego Mission Bay Resort
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Hard Rock Hotel San Diego
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4 out of 5
4000 Coronado Bay Rd Coronado CA
Fully refundableReserve now, pay when you stay
Loews Coronado Bay Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
Wyndham San Diego Bayside
Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4 out of 5
1500 Orange Ave Coronado CA
Fully refundableReserve now, pay when you stay
Hotel del Coronado, Curio Collection by Hilton
Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark

4 out of 5
675 L St San Diego CA
Omni San Diego Hotel at the Ballpark
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
Sheraton San Diego Resort
San Diego Marriott Gaslamp Quarter

San Diego Marriott Gaslamp Quarter

4 out of 5
660 K St San Diego CA
San Diego Marriott Gaslamp Quarter
See all 4,911 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.