2025 4 Star Hotels in Otay Mesa

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Featured Otay Mesa 4 Star Hotels

Hotel del Coronado, Curio Collection by Hilton

Hotel del Coronado, Curio Collection by Hilton

4 out of 5
1500 Orange Ave, Coronado, CA
Fully refundableReserve now, pay when you stay
Hotel del Coronado, Curio Collection by Hilton
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Wyndham San Diego Bayside
Palihotel San Diego Gaslamp Quarter

Palihotel San Diego Gaslamp Quarter

4 out of 5
830 Sixth Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
Palihotel San Diego Gaslamp Quarter
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
Manchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave, San Diego, CA
Fully refundableReserve now, pay when you stay
Hard Rock Hotel San Diego
Loews Coronado Bay Resort

Loews Coronado Bay Resort

4 out of 5
4000 Coronado Bay Rd, Coronado, CA
Fully refundableReserve now, pay when you stay
Loews Coronado Bay Resort
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr, San Diego, CA
Sheraton San Diego Resort
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

4 out of 5
601 Pacific Hwy, San Diego, CA
Fully refundableReserve now, pay when you stay
Embassy Suites by Hilton San Diego Bay Downtown
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
San Diego Mission Bay Resort
See all 4,773 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.