2026 5 Star Hotels in Otay Mesa

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Featured Otay Mesa 5 Star Hotels

Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street San Diego CA
Fully refundableReserve now, pay when you stay
Pendry San Diego
The US Grant, a Luxury Collection Hotel, San Diego

The US Grant, a Luxury Collection Hotel, San Diego

5 out of 5
326 Broadway San Diego CA
Fully refundableReserve now, pay when you stay
The US Grant, a Luxury Collection Hotel, San Diego
Shore House at The Del, LXR Hotels & Resorts

Shore House at The Del, LXR Hotels & Resorts

5 out of 5
1500 Orange Avenue Coronado CA
Shore House at The Del, LXR Hotels & Resorts
The Bower Coronado

The Bower Coronado

5 out of 5
1417 Orange Ave Coronado CA
Fully refundableReserve now, pay when you stay
The Bower Coronado
Beach Village at The Del, LXR Hotels & Resorts

Beach Village at The Del, LXR Hotels & Resorts

5 out of 5
1500 Orange Avenue Coronado CA
Beach Village at The Del, LXR Hotels & Resorts
See all 4,903 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.