
Cheap 2025 Medical Center District Hotels
Photo by Linda Cronan
Choose from 4633 Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd San Antonio TX
2.3 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

San Antonio Marriott Northwest Medical Center
3233 NW Loop 410 San Antonio TX
Free Cancellation
Reserve now, pay when you stay
2.88 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy a free area shuttle, room service, and a 24-hour fitness center. Our guests praise the helpful ...

Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr San Antonio TX
Free Cancellation
Reserve now, pay when you stay
1.49 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...

Crockett Hotel
320 Bonham San Antonio TX
Free Cancellation
Reserve now, pay when you stay
12.65 km from Medical Center District
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, valet parking (surcharge), and a 24-hour front desk. Our guests praise the pool and the restaurant ...

Hotel Valencia Riverwalk
150 E Houston St San Antonio TX
12.1 km from Medical Center District
Book a stay at this luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff and the ...

Riverwalk Plaza
100 Villita Street San Antonio TX
Free Cancellation
Reserve now, pay when you stay
12.3 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...

Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street San Antonio TX
Free Cancellation
Reserve now, pay when you stay
12.29 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in ...

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
9700 West Military Drive San Antonio TX
Free Cancellation
11.28 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the helpful staff in ...

Omni La Mansion del Rio
112 College St San Antonio TX
Free Cancellation
Reserve now, pay when you stay
12.28 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...

Sonesta ES Suites San Antonio Downtown Alamo Plaza
425 Bonham San Antonio TX
Free Cancellation
Reserve now, pay when you stay
12.63 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...

Hotel Contessa
306 W Market Street San Antonio TX
Free Cancellation
Reserve now, pay when you stay
12.51 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...

Hyatt Regency San Antonio Riverwalk
123 Losoya St San Antonio TX
Free Cancellation
Reserve now, pay when you stay
12.41 km from Medical Center District
Book a stay at this spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the clean rooms ...

La Quinta Inn & Suites by Wyndham San Antonio Downtown
100 W. Cesar Chavez Blvd San Antonio TX
12.34 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

Menger Hotel
204 Alamo Plaza San Antonio TX
Free Cancellation
Reserve now, pay when you stay
12.59 km from Medical Center District
Book a stay at this historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our reviews. ...

Hampton Inn & Suites San Antonio-Airport
8902 Jones Maltsberger Rd San Antonio TX
Free Cancellation
Reserve now, pay when you stay
9.2 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a free airport shuttle. Our guests praise the breakfast and ...
Don't see what you're looking for?
See all available properties in Medical Center District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Medical Center District, San Antonio Hotel Guide
Search for hotels in Medical Center District on Expedia.com. You can easily find your hotels in Medical Center District using one of the methods below:
- View our selection of featured hotels in Medical Center District
- Use the map to find hotels in the Medical Center District neighborhood you prefer
- Use the filters to see hotels in a specific area of Medical Center District, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Medical Center District
- Enter your travel dates to view the best deals on hotels in Medical Center District - while they last
