
Cheap 2025 Medical Center District Hotels
Photo by Linda Cronan
Choose from 4654 Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
4431 Horizon Hill Blvd, San Antonio, TX
2.3 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...

San Antonio Marriott Northwest Medical Center
3233 NW Loop 410, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
2.88 km from Medical Center District
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...

Courtyard by Marriott Medical Center San Antonio
8585 Marriott Dr, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
1.49 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...

Fairfield Inn & Suites by Marriott San Antonio Medical Center
7203 Wurzbach Road, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
0.97 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

Riverwalk Plaza
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.3 km from Medical Center District
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...

Drury Plaza Hotel San Antonio Riverwalk
105 S Saint Marys Street, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.29 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...

Hotel Valencia Riverwalk
150 E Houston St, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.1 km from Medical Center District
Stay at this 4.5-star luxury hotel in San Antonio. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the bar and the helpful ...

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
9700 West Military Drive, San Antonio, TX
Free Cancellation
11.28 km from Medical Center District
Stay at this 3.5-star family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and a lazy river. Our guests praise the pool and the helpful staff ...

Sonesta ES Suites San Antonio Downtown Alamo Plaza
425 Bonham, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.63 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...

Hotel Contessa
306 W Market Street, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.51 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...

Menger Hotel
204 Alamo Plaza, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.59 km from Medical Center District
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...

The Westin Riverwalk, San Antonio
420 W Market St, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.43 km from Medical Center District
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...

Hyatt Regency San Antonio Riverwalk
123 Losoya St, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.41 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the bar and the helpful staff in our ...

Omni La Mansion del Rio
112 College St, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
12.28 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...

The Westin San Antonio North
9821 Colonnade Blvd, San Antonio, TX
Free Cancellation
Reserve now, pay when you stay
3.43 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...
Don't see what you're looking for?
See all available properties in Medical Center District
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Medical Center District, San Antonio Hotel Guide
Search for hotels in Medical Center District on Expedia.com. You can easily find your hotels in Medical Center District using one of the methods below:
- View our selection of featured hotels in Medical Center District
- Use the map to find hotels in the Medical Center District neighborhood you prefer
- Use the filters to see hotels in a specific area of Medical Center District, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Medical Center District
- Enter your travel dates to view the best deals on hotels in Medical Center District - while they last