De Soto Vacations

Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*

Choose two or more items and save on your trip:

Top Hotel Deals

Edgetowner Motel

Edgetowner Motel

2.5 out of 5
804 Guthrie St De Soto IA
0.51 km from city center
Book a stay at this business-friendly motel in De Soto. Enjoy free parking, a business center, and a garden. Popular attractions Van Meter Recreation Complex ...
Sonesta Simply Suites Des Moines

Sonesta Simply Suites Des Moines

2 out of 5
7625 Office Plaza Dr N West Des Moines IA
17.45 km from city center
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful ...
Hyatt Place West Des Moines Jordan Creek

Hyatt Place West Des Moines Jordan Creek

3 out of 5
295 South 64th st West Des Moines IA
17.97 km from city center
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Stoney Creek Hotel Des Moines - Johnston

Stoney Creek Hotel Des Moines - Johnston

2.5 out of 5
5291 Stoney Creek Court Johnston IA
26.69 km from city center
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
Drury Inn & Suites West Des Moines

Drury Inn & Suites West Des Moines

3 out of 5
5505 Mills Civic Pkwy West Des Moines IA
19.03 km from city center
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Fairfield Inn and Suites by Marriott Des Moines West

Fairfield Inn and Suites by Marriott Des Moines West

2.5 out of 5
7225 Vista Dr West Des Moines IA
17.95 km from city center
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Wildwood Lodge

Wildwood Lodge

3 out of 5
11431 Forest Ave Clive IA
21.01 km from city center
Stay at this hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Days Inn & Suites by Wyndham Des Moines Airport

Days Inn & Suites by Wyndham Des Moines Airport

2 out of 5
1901 Hackley Ave Des Moines IA
30.21 km from city center
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hampton Inn Des Moines-Airport

Hampton Inn Des Moines-Airport

2.5 out of 5
5001 Fleur Dr Des Moines IA
30.23 km from city center
Stay at this hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Ramada Tropics Resort & Conf Center by Wyndham Des Moines

Ramada Tropics Resort & Conf Center by Wyndham Des Moines

3 out of 5
5000 Merle Hay Rd Urbandale IA
28.98 km from city center
Book a stay at this family-friendly hotel in Urbandale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
SpringHill Suites Des Moines West

SpringHill Suites Des Moines West

3 out of 5
1236 Jordan Creek Pkwy West Des Moines IA
17.59 km from city center
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the breakfast ...
Sheraton West Des Moines Hotel

Sheraton West Des Moines Hotel

3.5 out of 5
1800 50th St West Des Moines IA
20.96 km from city center
Book a stay at this business-friendly hotel in West Des Moines. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful ...
Homewood Suites by Hilton Des Moines Airport

Homewood Suites by Hilton Des Moines Airport

3 out of 5
7201 Sw 22nd St Des Moines IA
30.15 km from city center
Stay at this hotel in Des Moines. Enjoy free breakfast, free parking, and a free airport shuttle. Our guests praise the helpful staff and the clean rooms in ...
Country Inn & Suites by Radisson, Des Moines West, IA

Country Inn & Suites by Radisson, Des Moines West, IA

3 out of 5
1350 Nw 118th St Clive IA
20.65 km from city center
Book a stay at this business-friendly hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
Quality Inn & Suites Des Moines - Merle Hay Road

Quality Inn & Suites Des Moines - Merle Hay Road

2.5 out of 5
4995 Merle Hay Rd Des Moines IA
29.01 km from city center
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Don't see what you're looking for?
See all available properties in De Soto
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sat, Mar 14 - Mon, Mar 23
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$155 Roundtrip, found 1 day ago
$155
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sat, Mar 14 from Sky Harbor Intl. to Des Moines Intl., returning Mon, Mar 23, priced at $155 found 1 day ago
Delta
Wed, Mar 25 - Tue, Apr 7
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$249 Roundtrip, found 1 day ago
$249
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Mar 25 from Sky Harbor Intl. to Des Moines Intl., returning Tue, Apr 7, priced at $249 found 1 day ago
American Airlines
Tue, Jun 16 - Tue, Jun 23
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$269 Roundtrip, found 6 hours ago
$269
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Tue, Jun 16 from Sky Harbor Intl. to Des Moines Intl., returning Tue, Jun 23, priced at $269 found 6 hours ago
United
Tue, Jun 16 - Tue, Jun 23
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$289 Roundtrip, found 6 hours ago
$289
Roundtrip
found 6 hours ago
Select United flight, departing Tue, Jun 16 from Sky Harbor Intl. to Des Moines Intl., returning Tue, Jun 23, priced at $289 found 6 hours ago
Southwest Airlines
Tue, Jun 16 - Tue, Jun 23
PHX
Sky Harbor Intl.
DSM
Des Moines Intl.
$289 Roundtrip, found 6 hours ago
$289
Roundtrip
found 6 hours ago
Select Southwest Airlines flight, departing Tue, Jun 16 from Sky Harbor Intl. to Des Moines Intl., returning Tue, Jun 23, priced at $289 found 6 hours ago