De Soto Vacations
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Top Hotel Deals
Edgetowner Motel
804 Guthrie St De Soto IA
Book a stay at this business-friendly motel in De Soto. Enjoy free parking, a business center, and a garden. Popular attractions Van Meter Recreation Complex ...
Fairfield Inn and Suites by Marriott Des Moines West
7225 Vista Dr West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Stoney Creek Hotel Des Moines - Johnston
5291 Stoney Creek Court Johnston IA
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
Days Inn & Suites by Wyndham Des Moines Airport
1901 Hackley Ave Des Moines IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free parking, and a free airport shuttle. Our guests praise the breakfast and ...
Wildwood Lodge
11431 Forest Ave Clive IA
Stay at this hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Ramada Tropics Resort & Conf Center by Wyndham Des Moines
5000 Merle Hay Rd Urbandale IA
Book a stay at this family-friendly hotel in Urbandale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
GrandStay Hotel & Suites
6215 Merle Hay Road Johnston IA
Stay at this hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Iowa Gold Star Military Museum and Merle Hay Mall are ...
Sonesta Essential Des Moines
4755 Merle Hay Road Des Moines IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Country Inn & Suites by Radisson, Des Moines West, IA
1350 Nw 118th St Clive IA
Book a stay at this business-friendly hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
Motel 6 West Des Moines, IA
7655 Office Plaza Dr N West Des Moines IA
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
Hampton Inn Des Moines-Airport
5001 Fleur Dr Des Moines IA
Stay at this hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
Drury Inn & Suites West Des Moines
5505 Mills Civic Pkwy West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hyatt Place West Des Moines Jordan Creek
295 South 64th st West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Baymont by Wyndham Des Moines Airport
6221 Willow Creek Ave Des Moines IA
Book a stay at this family-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
Sheraton West Des Moines Hotel
1800 50th St West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Sat, Dec 12 - Thu, Dec 24
LAX
Los Angeles Intl.
DSM
Des Moines Intl.
$291
Roundtrip
found 5 days ago
Wed, Nov 11 - Tue, Nov 17
LAX
Los Angeles Intl.
DSM
Des Moines Intl.
$335
Roundtrip
found 5 days ago
Tue, Dec 15 - Mon, Dec 21
EWR
Newark Liberty Intl. Airport
DSM
Des Moines Intl.
$349
Roundtrip
found 1 day ago
Tue, Dec 15 - Mon, Dec 21
EWR
Newark Liberty Intl. Airport
DSM
Des Moines Intl.
$349
Roundtrip
found 1 day ago
Thu, Nov 5 - Tue, Nov 17
SEA
Seattle - Tacoma Intl.
DSM
Des Moines Intl.
$360
Roundtrip
found 2 days ago
Best points of interest in De Soto
- Jordan Creek Town Center Vacations
- Drake University Vacations
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- Living History Farms Vacations
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- John Wayne Birthplace Museum Vacations
- The MidAmerican Energy Company RecPlex Vacations
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