De Soto Vacations
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Top Hotel Deals
Edgetowner Motel
804 Guthrie St De Soto IA
Book a stay at this business-friendly motel in De Soto. Enjoy free parking, a business center, and a garden. Popular attractions Van Meter Recreation Complex ...
Sonesta Essential Des Moines
4755 Merle Hay Road Des Moines IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...
Stoney Creek Hotel Des Moines - Johnston
5291 Stoney Creek Court Johnston IA
Book a stay at this business-friendly hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
Days Inn & Suites by Wyndham Des Moines Airport
1901 Hackley Ave Des Moines IA
Book a stay at this business-friendly hotel in Des Moines. Enjoy free breakfast, free parking, and a free airport shuttle. Our guests praise the breakfast and ...
GrandStay Hotel & Suites
6215 Merle Hay Road Johnston IA
Stay at this hotel in Johnston. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Iowa Gold Star Military Museum and Merle Hay Mall are ...
Ramada Tropics Resort & Conf Center by Wyndham Des Moines
5000 Merle Hay Rd Urbandale IA
Book a stay at this family-friendly hotel in Urbandale. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Country Inn & Suites by Radisson, Des Moines West, IA
1350 Nw 118th St Clive IA
Book a stay at this business-friendly hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our ...
Motel 6 West Des Moines, IA
7655 Office Plaza Dr N West Des Moines IA
Stay at this motel in West Des Moines. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our ...
La Quinta Inn & Suites by Wyndham Des Moines West Clive
1390 Nw 118th St Clive IA
Book a stay at this family-friendly hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Wildwood Lodge
11431 Forest Ave Clive IA
Stay at this hotel in Clive. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
Drury Inn & Suites West Des Moines
5505 Mills Civic Pkwy West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Fairfield Inn and Suites by Marriott Des Moines West
7225 Vista Dr West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Hampton Inn Des Moines-Airport
5001 Fleur Dr Des Moines IA
Stay at this hotel in Des Moines. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. ...
SpringHill Suites Des Moines West
1236 Jordan Creek Pkwy West Des Moines IA
Book a stay at this business-friendly hotel in West Des Moines. Enjoy free breakfast, free parking, and a 24-hour fitness center. Our guests praise the breakfast ...
Days Inn by Wyndham West Des Moines / Clive
1600 NW 114th St Clive IA
Book a stay at this business-friendly hotel in Clive. Enjoy free breakfast, free parking, and a 24-hour front desk. Popular attractions Jordan Creek Town Center ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Wed, Sep 16 - Fri, Sep 25
DFW
Dallas-Fort Worth Intl.
DSM
Des Moines Intl.
$232
Roundtrip
found 4 days ago
Sat, Oct 24 - Wed, Oct 28
SEA
Seattle - Tacoma Intl.
DSM
Des Moines Intl.
$355
Roundtrip
found 4 days ago
Sat, Sep 19 - Mon, Sep 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$366
Roundtrip
found 1 day ago
Sat, Sep 19 - Mon, Sep 21
DEN
Denver Intl.
DSM
Des Moines Intl.
$366
Roundtrip
found 1 day ago
Fri, Oct 23 - Mon, Oct 26
SEA
Seattle - Tacoma Intl.
DSM
Des Moines Intl.
$370
Roundtrip
found 4 days ago
Best points of interest in De Soto
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