Business Hotels in Sikeston 2025
Photo by Ryan Coleman
Featured Sikeston Business Hotels
Pear Tree Inn Sikeston
2602 E Malone Avenue Sikeston MO
Fully refundableReserve now, pay when you stay
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
Fully refundable
Drury Inn & Suites Jackson MO
225 Drury Lane, Jackson, MO
Fully refundableReserve now, pay when you stay
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Best Western Plus Sikeston
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
Drury Inn & Suites Cape Girardeau
3303 Campster Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
Holiday Inn Express & Suites Sikeston Southwest by IHG
115 Hospitality Dr Sikeston MO
Fully refundable
Comfort Suites Jackson-Cape Girardeau
2904 Old Orchard Rd Jackson MO
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
Quality Inn
2011 North Kingshighway, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Candlewood Suites Cape Girardeau by IHG
485 S Mount Auburn Rd Cape Girardeau MO
Fully refundable
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
Hampton Inn Cape Girardeau I 55 East
207 S Mt Auburn Rd, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
Travelodge by Wyndham Dexter
1608 E Business US 60 Dexter MO
Quality Inn Charleston - Sikeston
102 Drake St Charleston MO
Super 8 by Wyndham Sikeston/Miner Area
2609 E Malone Ave Sikeston MO
Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.