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Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Travelers can enjoy the indoor pool and spa treatments after exploring the area, then wake up to a delicious breakfast that makes mornings easy

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Photo gallery for Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Exterior - Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG (Cape Girardeau)
Indoor pool, open 8 AM to 11 PM, sun loungers - Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG (Cape Girardeau)
Free breakfast - Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG (Cape Girardeau)
Exterior - Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG (Cape Girardeau)
Suite, 1 Bedroom (Feature) | Premium bedding, down comforters, pillowtop beds, in-room safe - Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG (Cape Girardeau)
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 offers comfort in a rural setting with free breakfast and an indoor pool. Relax at the onsite spa and sun loungers by the pool. Dry cleaning, laundry services, and luggage storage are available, with highly praised staff.

Reviews

9.4 out of 10
Exceptional

Popular amenities

  • Free WiFi
  • Air conditioning

Room options

Available filters for rooms
Showing 9 of 9 rooms

View all photos for Suite, 2 Queen Beds, Accessible (Roll-In Shower)

Suite, 2 Queen Beds, Accessible (Roll-In Shower) | Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Roll-In Shower)

8.0 out of 10
Very good
(6 reviews)
  • 37 sq m
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds
  • Free WiFi

View all photos for Suite, 1 King Bed, Accessible (Roll-In Shower)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Roll-In Shower)

9.6 out of 10
Exceptional
(7 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 King Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed

9.6 out of 10
Exceptional
(35 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 2 Queen Beds

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds

9.6 out of 10
Exceptional
(65 reviews)
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds
  • Free WiFi

View all photos for Suite, 2 Queen Beds, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 2 Queen Beds, Accessible (Mobility)

9.4 out of 10
Exceptional
(17 reviews)
  • 37 sq m
  • 1 bedroom
  • Sleeps 6
  • 2 Queen Beds
  • Free WiFi

View all photos for Standard Room, 1 Queen Bed

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room, 1 Queen Bed

9.4 out of 10
Exceptional
(6 reviews)
  • 37 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 Queen Bed
  • Free WiFi

View all photos for Standard Room

Premium bedding, down comforters, pillowtop beds, in-room safe

Standard Room

8.4 out of 10
Very good
(5 reviews)
  • 37 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

View all photos for Suite, 1 Bedroom (Feature)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 Bedroom (Feature)

10.0 out of 10
Exceptional
(1 review)
  • 1 bedroom
  • Sleeps 2
  • 1 Queen Bed
  • Free WiFi

View all photos for Suite, 1 King Bed, Accessible (Mobility)

Premium bedding, down comforters, pillowtop beds, in-room safe

Suite, 1 King Bed, Accessible (Mobility)

10.0 out of 10
Exceptional
(2 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed
  • Free WiFi

About the neighborhood

Located in Cape Girardeau, Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG is in a rural area and near the airport. The area's natural beauty can be seen at Shawnee National Forest and Mississippi River. Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are also worth visiting. Visit our Cape Girardeau travel guide
Map
3253 William Street, Cape Girardeau, MO, 63701

What's nearby

  • View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park
    Riverfront Bridge Park
    6 min drive - 5.0 miles
  • Panorama of Academic Hall, Southeast Missouri State University
    Southeast Missouri State University
    7 min drive - 3.7 miles
  • Cape Splash Family Aquatic Center
    4 min drive - 2.9 miles
  • Century Casino & Hotel Cape Girardeau
    9 min drive - 6.5 miles
  • Hunter Valley Winery
    22 min drive - 20.2 miles

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    10 min drive

Restaurants

  • Chick-fil-A
    7 min walk
  • Rhodes
    20 min walk
  • McDonald's
    10 min walk
  • Panera Bread
    2 min walk
  • Taco Bell
    12 min walk

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Property amenities

Internet

  • Available in all rooms: Free WiFi and wired internet
  • Available in some public areas: Free WiFi and wired internet

Parking and transportation

  • Free self parking on site
  • Wheelchair-accessible parking available

Food and drink

  • Free breakfast available

Things to do

  • Full-service spa
  • Gym
  • Indoor pool

Family friendly

  • In-room microwave
  • Indoor pool
  • Laundry facilities
  • Mini-fridge

Conveniences

  • 24-hour front desk
  • Free newspapers in lobby
  • Laundry facilities
  • Luggage storage
  • Safe at front desk
  • Vending machine

Guest services

  • Dry cleaning/laundry service
  • Housekeeping (daily)
  • Porter/bellhop

Business services

  • 118 square feet of conference space
  • Business center
  • Meeting room

Outdoors

  • Pool loungers

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Assistive listening devices
  • Braille/raised signage
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible parking
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible path to elevator

More

  • 1 building
  • 4 floors
  • Banquet hall
  • Smoking not allowed

Room amenities

Bedroom

  • Down comforter
  • Pillow menu
  • Pillowtop mattress
  • Premium bedding

Bathroom

  • Free toiletries
  • Hair dryer
  • Private bathroom
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Entertainment

  • 52-inch flat-screen TV with premium cable channels

Food and drink

  • Coffee/tea maker
  • Microwave
  • Mini-fridge

More

  • Air conditioning (climate-controlled)
  • Connecting rooms available
  • Desk
  • Free local calls
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Separate sitting area

Policies

Check-in

Check-in start time: 3:00 PM; Check-in end time: anytime
Contactless check-in available
Minimum check-in age: 21

Check-out

Check-out before 11 AM
Contactless check-out available

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets not allowed

Children and extra beds

Children are welcome
Cribs (infant beds) are not available

Property payment types

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Cashless transactions are available
Safety features at this property include a fire extinguisher and a smoke detector
This property affirms that it follows the cleaning and disinfection practices of Clean Promise (IHG)

We should mention

Pool access available from 8 AM to 11 PM
The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Frequently asked questions

Does Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG have a pool?

Yes, this property has an indoor pool. Pool access is from 8 AM–11 PM.

Is Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG pet-friendly?

No, pets are not allowed at this property.

How much is parking?

Self parking is free at this property.

What time is check-in at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Check-in start time: 3:00 PM; Check-in end time: anytime.

What time is check-out at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG?

Check-out is at 11 AM.

Where is Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG located?

Situated near the airport, this spa hotel is 0.6 mi (1 km) from Saint Francis Medical Center and within 3 mi (5 km) of Saint Francis Healthcare System and Southeast Missouri Hospital. Cape Splash Family Aquatic Center is 3 mi (4.9 km) away.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Reviews

9.4

Exceptional

9.6

Cleanliness

9.4

Location

9.6

Staff & service

9.6

Property conditions & facilities
Rating 10 - Excellent. 777 out of 1002 reviews
Rating 8 - Good. 149 out of 1002 reviews
Rating 6 - Okay. 41 out of 1002 reviews
Rating 4 - Poor. 16 out of 1002 reviews
Rating 2 - Terrible. 19 out of 1002 reviews

Reviews

Verified

10/10 Excellent

Theresa

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The room was very spacious and great water pressure. Staff very kind to us, the breakfast was great as well
Stayed 2 nights in Jun 2026
Verified

10/10 Excellent

Karen

Liked: Cleanliness, amenities
Beds and pillows were very comfortable. Shower had excellent water pressure and consistent temperature. Breakfast was good and had many options.
Stayed 1 night in May 2026
Verified

10/10 Excellent

Michael

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel is in a convenient central area. Was clean and staff was friendly.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Amber

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This was probably the cleanest hotel we have ever stayed in. The beds were also very comfortable. Staff was also friendly and helpful.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Sara

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
For the price, this stay exceeded my expectations. Everything was clean and the staff were very helpful. The suite we stayed in had many helpful features. Breakfast also was delicious and there were many options.
Stayed 1 night in Apr 2026
Verified

10/10 Excellent

Vanessa

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This hotel was recommended by a friend of ours. The hotel staff were great. It was clean and quiet. Me and my husband enjoyed our stay.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Matthew

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel and room was extremely clean. The lobby and breakfast area was clean, well organized and inviting. There was plenty of parking. The breakfast was superior compared to most I've experienced and was really well laid out and organized and staff maintained supply of food superbly
Stayed 1 night in Apr 2026
Verified

10/10 Excellent

Arriel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean room staff is very nice parking it great
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

John

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Everything was excellent. Staff was very friendly and helpful.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Rex

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Breakfast was very good and staff was extremely friendly and rooms were very clean
Stayed 2 nights in Jan 2026
Verified

10/10 Excellent

Andrew

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I was amazed to find out this place is 20+ years old. It is in great shape. Room was wonderful. Breakfast was great; very lovely stay.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Cheryl

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Clean room.
Stayed 1 night in Apr 2026
Verified

8/10 Good

Mary

Liked: Cleanliness, staff & service, amenities
Clean, courteous staff
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Nellie

Liked: Cleanliness, amenities, property conditions & facilities
Clean room and staff was very friendly.
Stayed 2 nights in Nov 2025
Verified

10/10 Excellent

Summer

Liked: Cleanliness, staff & service, amenities
It was amazing check in to check out
Stayed 1 night in Aug 2025
Verified

10/10 Excellent

Deborah

Liked: Cleanliness, staff & service, amenities
Room was spacious and clean. Staff was nice and helpful. Good breakfast.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Dawn

Liked: Cleanliness, amenities, property conditions & facilities
Everyone kind & place very clean.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

David

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great staff and clean rooms.
Stayed 1 night in Sep 2025
Verified

10/10 Excellent

Connie

Liked: Cleanliness, staff & service, amenities
Spacious room, clean, & comfy with everything we needed.
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Emily

Liked: Cleanliness, property conditions & facilities
Clean and easy check in
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Brian

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly.
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Kelly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
It was right off the interstate with lots of restaurant options
Stayed 1 night in Sep 2025
Verified

10/10 Excellent

Andrew

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice room. There was a little noise from other rooms or perhaps from the hallways. The breakfast was very good.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Erik

Liked: Cleanliness, staff & service, amenities
The room was clean, the staff were friendly, and they gave out free cookies in the evening, not just breakfast in the morning.
Stayed 1 night in Nov 2025
Verified

8/10 Good

Carrie

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great room and good breakfast. Great place to stay with central location.
Stayed 1 night in May 2025