Santa Ana Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Santa Ana Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Megapolis Hotel Panamá
San Francisco
Price was $1,516, price is now $1,034 per person
$1,034
per person
May 14 - May 19
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Avenida Balboa and Via Espana are located nearby.
Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $1,866, price is now $1,207 per person
$1,207
per person
May 14 - May 19
found 1 day ago
Roundtrip non-stop flight included
New York (JFK) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Cinta Costera and Amador Causeway are located nearby.
Hotel Riu Plaza Panama
Bella Vista
Price was $1,648, price is now $1,195 per person
$1,195
per person
Apr 17 - Apr 24
found 2 hours ago
Roundtrip flight included
Sioux Falls (FSD) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Via Espana and Avenida Balboa are located nearby.
Dreams Playa Bonita Panama - All Inclusive
Price was $2,407, price is now $1,827 per person
$1,827
per person
Apr 17 - Apr 24
found 2 hours ago
Roundtrip flight included
Sioux Falls (FSD) to Panama City (PTY)
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Amador Causeway and Albrook Shopping Mall are located nearby.
Hyatt Regency Panama City
Bella Vista
Price was $1,858, price is now $1,436 per person
$1,436
per person
Apr 17 - Apr 24
found 2 hours ago
Roundtrip flight included
Sioux Falls (FSD) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Via Espana and Avenida Balboa are located nearby.
Riande Aeropuerto Hotel & Casino
Price was $1,606, price is now $1,257 per person
$1,257
per person
Apr 17 - Apr 24
found 2 hours ago
Roundtrip flight included
Sioux Falls (FSD) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.
Top Hotel Deals
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
0.31 km from Santa Ana
Book a stay at this business-friendly condo in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Cinta Costera ...
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
3.57 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Sheraton Grand Panama
Via Israel And 77th Street Panama City Panama
5.69 km from Santa Ana
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
21.06 km from Santa Ana
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
3.31 km from Santa Ana
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
W Panama
Calle Aquilino de la Guardia & Calle 50 Panama City
3.19 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
Waymore Hotel Spa & Casino
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
3.48 km from Santa Ana
Book a stay at this spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Via Espana and Avenida Balboa are located ...
Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz Veracruz Panama
7.86 km from Santa Ana
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
The Executive Hotel
Calle 52 Panama City Panama
3.23 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Principe Hotel and Suites
Via Argentina Panama City Panama
3.93 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
Waldorf Astoria Panama
47th St. & Uruguay Street Panama City Panama
2.87 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Ramada Plaza by Wyndham Panama Punta Pacifica
Via Israel y Calle 71, San Francisco Panama City Panama
5.07 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
Marriott Panama Hotel
Roosevelt Ave., Allbrook Mall Panama City Panama
2.06 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Thu, May 7 - Mon, May 11
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$344 Roundtrip, just found
$344
Roundtrip
just found
Mon, Oct 26 - Sun, Nov 1
MIA
Miami Intl.
PTY
Tocumen Intl.
$351 Roundtrip, found 4 days ago
$351
Roundtrip
found 4 days ago
Mon, Oct 26 - Sun, Nov 1
MIA
Miami Intl.
PTY
Tocumen Intl.
$361 Roundtrip, found 4 days ago
$361
Roundtrip
found 4 days ago
Mon, Oct 26 - Sun, Nov 1
MIA
Miami Intl.
PTY
Tocumen Intl.
$380 Roundtrip, found 4 days ago
$380
Roundtrip
found 4 days ago
Sun, Apr 19 - Wed, Apr 22
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$466 Roundtrip, found 1 day ago
$466
Roundtrip
found 1 day ago