Santa Ana Vacation Packages for 2026

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Top Hotel Deals

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
0.31 km from Santa Ana
Stay at this condo in Panama City. Enjoy free WiFi, a 24-hour front desk, and a garden. Popular attractions Albrook Shopping Mall and Cinta Costera are located ...
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
3.57 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
20.54 km from Santa Ana
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
3.64 km from Santa Ana
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful ...
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
2.87 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Marriott Panama Hotel

Marriott Panama Hotel

4 out of 5
Roosevelt Ave., Allbrook Mall Panama City Panama
2.06 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
3.48 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
3.93 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5 out of 5
Km 6 Road to Veracruz Veracruz Panama
7.51 km from Santa Ana
Book a stay at this luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
3.31 km from Santa Ana
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
7.86 km from Santa Ana
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
3.38 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Decapolis Hotel Panama City

Decapolis Hotel Panama City

4 out of 5
Avenida Balboa Con Multicentro Panama City Panama
3.55 km from Santa Ana
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff ...
Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
Via Israel And 77th Street Panama City Panama
5.69 km from Santa Ana
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition ...
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
4.27 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Tue, Mar 17 - Wed, Mar 25
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$385 Roundtrip, found 4 days ago
$385
Roundtrip
found 4 days ago
Select United flight, departing Tue, Mar 17 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Wed, Mar 25, priced at $385 found 4 days ago
Copa
Sun, Mar 15 - Tue, Mar 24
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$418 Roundtrip, found 4 days ago
$418
Roundtrip
found 4 days ago
Select Copa flight, departing Sun, Mar 15 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Tue, Mar 24, priced at $418 found 4 days ago
Delta
Wed, Nov 4 - Thu, Nov 5
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$430 Roundtrip, found 4 days ago
$430
Roundtrip
found 4 days ago
Select Delta flight, departing Wed, Nov 4 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Thu, Nov 5, priced at $430 found 4 days ago
American Airlines
Wed, Apr 8 - Thu, Apr 16
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$445 Roundtrip, found 5 days ago
$445
Roundtrip
found 5 days ago
Select American Airlines flight, departing Wed, Apr 8 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Thu, Apr 16, priced at $445 found 5 days ago
avianca
Thu, Feb 26 - Sun, Mar 22
LAX
Los Angeles Intl.
PTY
Tocumen Intl.
$579 Roundtrip, found 4 days ago
$579
Roundtrip
found 4 days ago
Select avianca flight, departing Thu, Feb 26 from Los Angeles Intl. to Tocumen Intl., returning Sun, Mar 22, priced at $579 found 4 days ago