Santa Ana Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Santa Ana Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
Bella Vista
Price was $1,296, price is now $943 per person
$943
per person
Jun 1 - Jun 6
found 23 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Wanders Panama by Boutique Apartments
San Francisco
Price was $3,644, price is now $2,951 per person
$2,951
per person
May 31 - Jun 6
found 22 hours ago
Roundtrip non-stop flight included
New York (JFK) to Panama City (PTY)
Book a stay at this spa apartment in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Summit Rainforest Golf Resort & All Inclusive
Price was $2,114, price is now $1,741 per person
$1,741
per person
Jun 28 - Jul 4
found 23 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Book a stay at this golf hotel in Panama City. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Centenario Bridge and Summit Botanical Gardens & Zoo are located nearby.
Hotel Plaza Herrera
Casco Viejo
Price was $1,882, price is now $1,578 per person
$1,578
per person
Jun 28 - Jul 4
found 23 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, an attached winery, and 2 bars/lounges. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Central Hotel Panama Casco Viejo
Casco Viejo
Price was $1,956, price is now $1,289 per person
$1,289
per person
Jun 1 - Jun 6
found 23 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Megapolis Hotel Panamá
San Francisco
Price was $1,528, price is now $1,123 per person
$1,123
per person
Jun 1 - Jun 6
found 22 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Top Hotel Deals
Casco View Apartments
C. 16 Oeste Panama City Provincia de Panamá
0.31 km from Santa Ana
Book a stay at this business-friendly condo in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Albrook Shopping ...
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
3.57 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
21.06 km from Santa Ana
Book a stay at this family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
The Executive Hotel
Calle 52 Panama City Panama
3.23 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Principe Hotel and Suites
Via Argentina Panama City Panama
3.93 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz Veracruz Panama
7.86 km from Santa Ana
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Plaza Paitilla Inn Hotel
Italy Avenue, Punta Paitilla Panama City Panama
3.38 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Radisson Hotel Panama Canal
Amador Avenue & Van Hook Street Panama City Panama
2.31 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff and the property condition ...
Waymore Hotel Spa & Casino
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
3.48 km from Santa Ana
Book a stay at this spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Avenida Balboa are ...
Hyatt Regency Panama City
Calle 52 and Ricardo Arias Panama City
3.28 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Popular attractions Albrook Shopping Mall and Avenida ...
Hotel Ojos del Rio
calle 41 este Panama City Panama
2.19 km from Santa Ana
Stay at this hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
Courtyard by Marriott Panama Multiplaza Mall
Via Israel Multiplaza Pacific Mall Panama City Panama
4.48 km from Santa Ana
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
JW Marriott Panama
Calle Punta Colon, Punta Pacifica Panama City Panama
4.27 km from Santa Ana
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Wed, Jul 1 - Sun, Jul 5
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$250 Roundtrip, found 9 hours ago
$250
Roundtrip
found 9 hours ago
Wed, Jul 1 - Sun, Jul 5
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$275 Roundtrip, found 9 hours ago
$275
Roundtrip
found 9 hours ago
Mon, Oct 26 - Sun, Nov 1
MIA
Miami Intl.
PTY
Tocumen Intl.
$417 Roundtrip, found 5 days ago
$417
Roundtrip
found 5 days ago
Fri, May 15 - Fri, Jun 5
MIA
Miami Intl.
PTY
Tocumen Intl.
$453 Roundtrip, found 4 days ago
$453
Roundtrip
found 4 days ago
Mon, Aug 31 - Thu, Sep 3
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$596 Roundtrip, found 4 days ago
$596
Roundtrip
found 4 days ago