Santa Ana Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
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Santa Ana Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel
Amador
Price was $834, price is now $623 per person
$623
per person
Nov 27 - Dec 2
found 2 days ago
Roundtrip non-stop flight included
Baltimore (BWI) to Panama City (PTY)
Stay at this 3.5-star hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.
Central Hotel Panama Casco Viejo
Casco Viejo
Save 100% on your flight
Price was $1,783, price is now $879 per person
$879
per person
Nov 27 - Dec 2
found 1 day ago
Roundtrip non-stop flight included
Baltimore (BWI) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Hotel Riu Plaza Panama
Bella Vista
Price was $1,064, price is now $761 per person
$761
per person
Nov 27 - Dec 2
found 1 day ago
Roundtrip non-stop flight included
Baltimore (BWI) to Panama City (PTY)
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Bristol Panama, a Registry Collection Hotel
Bella Vista
Price was $2,070, price is now $1,543 per person
$1,543
per person
Dec 21 - Dec 28
found 7 hours ago
Roundtrip non-stop flight included
Los Angeles (LAX) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Dreams Playa Bonita Panama - All Inclusive
Price was $1,638, price is now $1,244 per person
$1,244
per person
Nov 27 - Dec 2
found 1 day ago
Roundtrip non-stop flight included
Baltimore (BWI) to Panama City (PTY)
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.
Las Americas Golden Tower Panama
San Francisco
Price was $1,093, price is now $832 per person
$832
per person
Nov 27 - Dec 2
found 1 day ago
Roundtrip non-stop flight included
Baltimore (BWI) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Top Hotel Deals
Casco View Apartments
C. 16 Oeste, Panama City, Provincia de Panamá
0.31 km from Santa Ana
Stay at this 3.5-star condo in Panama City. Enjoy free WiFi, a 24-hour front desk, and a garden. Popular attractions Albrook Shopping Mall and Cinta Costera ...
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
3.57 km from Santa Ana
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
21.06 km from Santa Ana
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz, Veracruz, Panama
7.86 km from Santa Ana
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Megapolis Hotel Panamá
Avenida Balboa, Panama City
3.48 km from Santa Ana
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Marriott Panama Hotel
Roosevelt Ave., Allbrook Mall, Panama City, Panama
2.06 km from Santa Ana
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Waldorf Astoria Panama
47th St. & Uruguay Street, Panama City, Panama
2.87 km from Santa Ana
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Principe Hotel and Suites
Via Argentina, Panama City, Panama
3.93 km from Santa Ana
Stay at this 3-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
Central Hotel Panama Casco Viejo
Plaza de la Independencia Casco Viejo, Panama City, Panama
0.88 km from Santa Ana
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
The Westin Playa Bonita Panama
Km 6 Road to Veracruz, Veracruz, Panama
7.51 km from Santa Ana
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
W Panama
Calle Aquilino de la Guardia & Calle 50, Bella Vista, Panama City
3.19 km from Santa Ana
Stay at this 5-star luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
JW Marriott Panama
Calle Punta Colon, Punta Pacifica, Panama City, Panama
4.29 km from Santa Ana
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
Studio Coliving
Av. Ricardo Arango y, Av. Federico Boyd, Panama City, Panama
3.11 km from Santa Ana
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Thu, Dec 25 - Wed, Dec 31
MIA
Miami Intl.
PTY
Tocumen Intl.
$377 Roundtrip, found 4 hours ago
$377
Roundtrip
found 4 hours ago
Fri, Dec 5 - Sat, Dec 13
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$555 Roundtrip, found 1 day ago
$555
Roundtrip
found 1 day ago
Thu, Dec 4 - Tue, Dec 9
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$570 Roundtrip, found 1 day ago
$570
Roundtrip
found 1 day ago
Sun, Jun 14 - Tue, Jun 23
JFK
John F. Kennedy Intl.
PTY
Tocumen Intl.
$1,053 Roundtrip, found 3 days ago
$1,053
Roundtrip
found 3 days ago
Sat, Dec 20 - Wed, Dec 31
JFK
John F. Kennedy Intl.
PTY
Tocumen Intl.
$1,662 Roundtrip, found 1 hour ago
$1,662
Roundtrip
found 1 hour ago