Santa Ana Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Photo by Isa
Santa Ana Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama
Bella Vista
Price was $1,092, price is now $861 per person
$861
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Bristol Panama, a Registry Collection Hotel
Bella Vista
Price was $1,262, price is now $1,008 per person
$1,008
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Central Hotel Panama Casco Viejo
Casco Viejo
Price was $1,522, price is now $1,254 per person
$1,254
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Mahogany Suites
Price was $996, price is now $862 per person
$862
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Stay at this hotel in Arraijan. Enjoy free WiFi and an outdoor pool. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.
La Concordia Boutique Hotel
Casco Viejo
Price was $1,178, price is now $1,024 per person
$1,024
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Stay at this 4-star family-friendly hotel in Panama City. Enjoy free WiFi, a rooftop terrace, and onsite spa services. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Hotel Plaza Herrera
Casco Viejo
Price was $1,383, price is now $1,223 per person
$1,223
per person
Oct 9 - Oct 13
found 1 day ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Panama City (PTY)
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and an attached winery. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Top Hotel Deals
Casco View Apartments
C. 16 Oeste, Panama City, Provincia de Panamá
0.31 km from Santa Ana
Stay at this 3.5-star condo in Panama City. Enjoy free WiFi, a 24-hour front desk, and a garden. Popular attractions Albrook Shopping Mall and Cinta Costera ...
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella, Panama City, Panama
3.57 km from Santa Ana
Stay at this 5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Dreams Playa Bonita Panama - All Inclusive
KM 7, Road to Veracruz, Veracruz, Panama
7.86 km from Santa Ana
Stay at this 4-star beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Waymore Hotel Spa & Casino
Calle Augusto Samuel Boyd y Calle Eusebi, Panama City
3.48 km from Santa Ana
Stay at this 4-star spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located ...
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama
21.06 km from Santa Ana
Stay at this 4-star family-friendly hotel in Tocumen. Enjoy free WiFi, breakfast (surcharge), and a free airport shuttle. Our guests praise the breakfast and ...
Megapolis Hotel Panamá
Avenida Balboa, Panama City
3.48 km from Santa Ana
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
The Westin Playa Bonita Panama
Km 6 Road to Veracruz, Veracruz, Panama
7.51 km from Santa Ana
Stay at this 5-star luxury hotel in Veracruz. Enjoy free parking, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Principe Hotel and Suites
Via Argentina, Panama City, Panama
3.93 km from Santa Ana
Stay at this 3-star business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
JW Marriott Panama
Calle Punta Colon, Punta Pacifica, Panama City, Panama
4.29 km from Santa Ana
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff and the property condition ...
Hotel Costa Inn
Ave. Peru, Calle 39, Panama City, Panama
2.07 km from Santa Ana
Stay at this 3-star hotel in Panama City. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Albrook Shopping Mall and Cinta Costera ...
Novotel Panama City
Calle Jose I. Fabrega y Thais de Pons, El Cangre, Bella Vista, Panama City, Panama
4.31 km from Santa Ana
Stay at this 4-star family-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the ...
The Executive Hotel
Calle 52, Aquilino de La Guardia, Panama City, Panama
3.23 km from Santa Ana
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool ...
Studio Coliving
Av. Ricardo Arango y, Av. Federico Boyd, Panama City, Panama
3.11 km from Santa Ana
Stay at this 4.5-star luxury hotel in Panama City. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Wed, Sep 10 - Thu, Sep 11
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$198 Roundtrip, found 5 days ago
$198
Roundtrip
found 5 days ago
Wed, Sep 17 - Thu, Sep 18
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$230 Roundtrip, found 1 day ago
$230
Roundtrip
found 1 day ago
Sun, Nov 9 - Sat, Nov 15
MIA
Miami Intl.
PTY
Tocumen Intl.
$362 Roundtrip, found 1 day ago
$362
Roundtrip
found 1 day ago
Wed, Sep 17 - Tue, Sep 23
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$391 Roundtrip, found 4 days ago
$391
Roundtrip
found 4 days ago
Tue, Jan 27 - Mon, Feb 9
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$519 Roundtrip, found 1 day ago
$519
Roundtrip
found 1 day ago