Otay Mesa West Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Otay Mesa West Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Paradise Point Resort & Spa
Mission Bay
Save 100% on your flight
Price was $809, price is now $492 per person
$492
per person
Mar 12 - Mar 16
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Mission Bay and Port of San Diego are located nearby.
The Sofia Hotel
Downtown San Diego
Save 100% on your flight
Price was $1,193, price is now $568 per person
$568
per person
Mar 20 - Mar 24
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and Petco Park are located nearby.
Margaritaville Hotel San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $1,366, price is now $784 per person
$784
per person
Mar 20 - Mar 24
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Stay at this hotel in San Diego. Enjoy a rooftop terrace, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
La Jolla Cove Suites
Village of La Jolla
Save 100% on your flight
Price was $1,291, price is now $799 per person
$799
per person
Mar 20 - Mar 24
found 10 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Book a stay at this beach hotel in La Jolla. Enjoy breakfast (surcharge), parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mission Bay and La Jolla Cove are located nearby.
The Beau Downtown San Diego Gaslamp Quar
Downtown San Diego
Save 100% on your flight
Price was $1,147, price is now $729 per person
$729
per person
Mar 20 - Mar 24
found 11 hours ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
Stay at this hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Popular attractions Petco Park and Port of San Diego are located nearby.
Los Bungalows
Save 100% on your flight
Price was $781, price is now $516 per person
$516
per person
Mar 12 - Mar 16
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this beach motel in Imperial Beach. Enjoy free WiFi, free parking, and laundry facilities. Our guests praise the helpful staff in our reviews. Popular attractions Las Americas Premium Outlets and Imperial Beach are located nearby.
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Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
21.38 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
22.12 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
19.06 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Courtyard by Marriott San Diego Downtown Little Italy
1646 Front St San Diego CA
19.15 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
DoubleTree by Hilton Hotel San Diego - Mission Valley
7450 Hazard Center Dr San Diego CA
23.53 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
Hilton San Diego Mission Valley
901 Camino Del Rio S San Diego CA
22.79 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
27.13 km from Otay Mesa West
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
17.51 km from Otay Mesa West
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Pendry San Diego
550 J Street San Diego CA
17.66 km from Otay Mesa West
Book a stay at this luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Best Western Seven Seas
411 Hotel Circle South San Diego CA
22.89 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Lafayette Hotel & Club
2223 El Cajon Blvd San Diego CA
21.31 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
San Diego Mission Bay Resort
1775 E Mission Bay Dr San Diego CA
26.81 km from Otay Mesa West
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S San Diego CA
22.93 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Fri, Feb 27 - Mon, Mar 9
DEN
Denver Intl.
SAN
San Diego Intl.
$48 Roundtrip, found 14 hours ago
$48
Roundtrip
found 14 hours ago
Mon, Mar 9 - Thu, Mar 12
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$97 Roundtrip, found 6 days ago
$97
Roundtrip
found 6 days ago
Tue, Mar 10 - Wed, Mar 25
PAE
Seattle Paine Field Intl. Airport
SAN
San Diego Intl.
$119 Roundtrip, found 5 days ago
$119
Roundtrip
found 5 days ago
Tue, Mar 24 - Wed, Apr 1
SEA
Seattle - Tacoma Intl.
CLD
McClellan-Palomar
$172 Roundtrip, found 1 hour ago
$172
Roundtrip
found 1 hour ago
Thu, Feb 19 - Tue, Feb 24
EWR
Newark Liberty Intl. Airport
SAN
San Diego Intl.
$207 Roundtrip, found 1 day ago
$207
Roundtrip
found 1 day ago