Mission Bay Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Mission Bay Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Margaritaville Hotel San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $1,024, price is now $608 per person
$608
per person
Sep 1 - Sep 5
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Stay at this hotel in San Diego. Enjoy a rooftop terrace, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
The Sofia Hotel
Downtown San Diego
Save 100% on your flight
Price was $1,150, price is now $615 per person
$615
per person
Sep 1 - Sep 5
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.
Paradise Point Resort & Spa
Mission Bay
Save 100% on your flight
Price was $1,121, price is now $704 per person
$704
per person
Sep 1 - Sep 5
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our reviews. Popular attractions Mission Bay and Mission Beach are located nearby.
Ocean Park Inn
Pacific Beach
Save 100% on your flight
Price was $2,592, price is now $1,648 per person
$1,648
per person
Aug 10 - Aug 16
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this beach hotel in San Diego. Enjoy free breakfast, free WiFi, and a beach locale. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Mission Beach and Mission Bay are located nearby.
Surfer Beach Hotel
Pacific Beach
Save 100% on your flight
Price was $1,730, price is now $1,177 per person
$1,177
per person
Aug 10 - Aug 16
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a beach locale, and parking (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Mission Beach and Mission Bay are located nearby.
Alma San Diego Downtown, a Tribute Portfolio Hotel
Downtown San Diego
Save 100% on your flight
Price was $1,176, price is now $807 per person
$807
per person
Jul 30 - Aug 3
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Book a stay at this boutique hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
Don't see what you're looking for?
See all available trips from Columbus to Mission Bay
View all tripsTop Hotel Deals
San Diego Mission Bay Resort
1775 E Mission Bay Dr San Diego CA
1.16 km from Mission Bay
Book a stay at this beach resort in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
Paradise Point Resort & Spa
1404 Vacation Rd San Diego CA
1.55 km from Mission Bay
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
1.75 km from Mission Bay
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
Hyatt Regency Mission Bay Spa and Marina
1441 Quivira Rd San Diego CA
2.01 km from Mission Bay
Book a stay at this spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
8.97 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
The Sofia Hotel
150 W Broadway San Diego CA
8.69 km from Mission Bay
Book a stay at this historic hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean ...
Wyndham San Diego Bayside
1355 N Harbor Drive San Diego CA
7.95 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Best Western Seven Seas
411 Hotel Circle South San Diego CA
5.61 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
9.66 km from Mission Bay
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
California Suites Hotel
5415 Clairemont Mesa Blvd San Diego CA
7.79 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the ...
Bahia Resort Hotel
998 W Mission Bay Dr San Diego CA
2.28 km from Mission Bay
Book a stay at this beach resort in San Diego. Enjoy a beach locale, breakfast (surcharge), and 24-hour room service. Our guests praise the pool and the restaurant ...
Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S San Diego CA
5.48 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...
Hotel del Coronado, Curio Collection by Hilton
1500 Orange Ave Coronado CA
11.45 km from Mission Bay
Book a stay at this beach resort in Coronado. Enjoy free WiFi, 6 restaurants, and a private beach. Our guests praise the helpful staff in our reviews. Popular ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Tue, Jul 21 - Tue, Jul 28
SFO
San Francisco Intl.
SAN
San Diego Intl.
$66 Roundtrip, found 6 hours ago
$66
Roundtrip
found 6 hours ago
Tue, Nov 3 - Tue, Dec 1
PDX
Portland Intl.
SAN
San Diego Intl.
$145 Roundtrip, found 7 hours ago
$145
Roundtrip
found 7 hours ago
Tue, Oct 6 - Tue, Oct 13
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$167 Roundtrip, found 3 hours ago
$167
Roundtrip
found 3 hours ago
Tue, Aug 25 - Tue, Sep 8
BOS
Logan Intl.
SAN
San Diego Intl.
$252 Roundtrip, found 2 days ago
$252
Roundtrip
found 2 days ago
Sun, Dec 6 - Sun, Dec 13
MSP
Minneapolis - St. Paul Intl.
SAN
San Diego Intl.
$267 Roundtrip, found 4 days ago
$267
Roundtrip
found 4 days ago