Mission Bay Vacation Packages for 2026

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Top Hotel Deals

The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
1.81 km from Mission Bay
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
San Diego Mission Bay Resort

San Diego Mission Bay Resort

4 out of 5
1775 E Mission Bay Dr San Diego CA
1.28 km from Mission Bay
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
1.48 km from Mission Bay
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd San Diego CA
2.01 km from Mission Bay
Book a stay at this spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Sheraton San Diego Resort

Sheraton San Diego Resort

4 out of 5
1380 Harbor Island Dr San Diego CA
5.95 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd San Diego CA
8.06 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
8.2 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4 out of 5
875 Hotel Circle South San Diego CA
5.27 km from Mission Bay
Book a stay at this spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
9.66 km from Mission Bay
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 out of 5
800 Bay Marina Dr National City CA
16.75 km from Mission Bay
Book a stay at this golf hotel in National City. Enjoy free WiFi, free parking, and a golf course. Our guests praise the pool and the restaurant in our reviews. ...
San Diego Marriott La Jolla

San Diego Marriott La Jolla

4 out of 5
4240 La Jolla Village Dr La Jolla CA
10.74 km from Mission Bay
Book a stay at this business-friendly hotel in La Jolla. Enjoy breakfast (surcharge), a 24-hour fitness center, and valet parking (surcharge). Our guests praise ...
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

4 out of 5
1646 Front St San Diego CA
8.08 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
6.77 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
7.95 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S San Diego CA
6.38 km from Mission Bay
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Feb 4 - Sun, Feb 8
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$99 Roundtrip, found 5 days ago
$99
Roundtrip
found 5 days ago
Select Delta flight, departing Wed, Feb 4 from Seattle - Tacoma Intl. to San Diego Intl., returning Sun, Feb 8, priced at $99 found 5 days ago
Alaska Airlines
Sat, Feb 21 - Fri, Feb 27
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$119 Roundtrip, found 2 days ago
$119
Roundtrip
found 2 days ago
Select Alaska Airlines flight, departing Sat, Feb 21 from Seattle - Tacoma Intl. to San Diego Intl., returning Fri, Feb 27, priced at $119 found 2 days ago
Frontier Airlines
Wed, Dec 24 - Mon, Dec 29
DEN
Denver Intl.
SAN
San Diego Intl.
$172 Roundtrip, found 2 days ago
$172
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Wed, Dec 24 from Denver Intl. to San Diego Intl., returning Mon, Dec 29, priced at $172 found 2 days ago
Southwest Airlines
Wed, Feb 4 - Sun, Feb 8
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$189 Roundtrip, found 5 days ago
$189
Roundtrip
found 5 days ago
Select Southwest Airlines flight, departing Wed, Feb 4 from Seattle - Tacoma Intl. to San Diego Intl., returning Sun, Feb 8, priced at $189 found 5 days ago
Hawaiian Airlines
Sat, Feb 21 - Sat, Mar 7
EWR
Newark Liberty Intl. Airport
SAN
San Diego Intl.
$197 Roundtrip, found 14 hours ago
$197
Roundtrip
found 14 hours ago
Select Hawaiian Airlines flight, departing Sat, Feb 21 from Newark Liberty Intl. Airport to San Diego Intl., returning Sat, Mar 7, priced at $197 found 14 hours ago