Medical Center District Vacation Packages for 2025

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Medical Center District Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Comfort Inn and Suites Near Medical Center

Comfort Inn and Suites Near Medical Center

2.5 out of 5
per person
Jul 12 - Jul 16
found 15 hours ago
Roundtrip non-stop flight included
Rochester (RST) to San Antonio (SAT)
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions San Antonio Zoo and Aquarium and Alamo are located nearby.

Hotel Havana

Hotel Havana

3.5 out of 5
Downtown San Antonio
per person
Jul 12 - Jul 16
found 16 hours ago
Roundtrip non-stop flight included
Rochester (RST) to San Antonio (SAT)
Stay at this 3.5-star hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the room service in our reviews. Popular attractions Alamo and River Walk are located nearby.

Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area

Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area

2.5 out of 5
Park Village
per person
Jul 12 - Jul 16
found 16 hours ago
Roundtrip non-stop flight included
Rochester (RST) to San Antonio (SAT)
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions San Antonio Zoo and Aquarium and Frost Bank Center are located nearby.

O´Brien Historic Hotel

O´Brien Historic Hotel

3.5 out of 5
Downtown San Antonio
per person
Jul 12 - Jul 16
found 15 hours ago
Roundtrip non-stop flight included
Rochester (RST) to San Antonio (SAT)
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions River Walk and San Antonio River are located nearby.

Days Inn & Suites by Wyndham San Antonio near Frost Bank Center

Days Inn & Suites by Wyndham San Antonio near Frost Bank Center

2.5 out of 5
Arena District
per person
Jul 12 - Jul 16
found 15 hours ago
Roundtrip non-stop flight included
Rochester (RST) to San Antonio (SAT)
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Alamodome and Alamo are located nearby.

Tru by Hilton San Antonio North

Tru by Hilton San Antonio North

2.5 out of 5
per person
Jul 12 - Jul 16
found 16 hours ago
Roundtrip non-stop flight included
Rochester (RST) to San Antonio (SAT)
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Village at Stone Oak and Stone Ridge Market are located nearby.

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Top Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
2.3 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
2.88 km from Medical Center District
Stay at this 3.5-star business-friendly hotel in San Antonio. Enjoy free parking, a free area shuttle, and room service. Our guests praise the helpful staff ...
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr, San Antonio, TX
1.49 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and ...
Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center

3 out of 5
9806 Interstate Hwy 10 W, San Antonio, TX
3.1 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street, Dwyer/Main Plaza, San Antonio, TX
12.3 km from Medical Center District
Stay at this 4-star family-friendly hotel in San Antonio. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the restaurant and the ...
Sonesta ES Suites San Antonio Downtown Alamo Plaza

Sonesta ES Suites San Antonio Downtown Alamo Plaza

3 out of 5
425 Bonham, San Antonio, TX
12.63 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and an outdoor pool. Our guests praise the breakfast and the helpful ...
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street, San Antonio, TX
12.96 km from Medical Center District
Book a stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
La Cantera Resort & Spa

La Cantera Resort & Spa

4 out of 5
16641 La Cantera Pkwy, San Antonio, TX
11.32 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy 5 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff ...
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street, San Antonio, TX
12.29 km from Medical Center District
Stay at this 3-star business-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
The Westin Riverwalk, San Antonio

The Westin Riverwalk, San Antonio

4 out of 5
420 W Market St, San Antonio, TX
12.43 km from Medical Center District
Stay at this 4-star business-friendly hotel in San Antonio. Enjoy 2 bars/lounges, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the ...
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza, San Antonio, TX
12.59 km from Medical Center District
Stay at this 3.5-star historic hotel in San Antonio. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the bar in our ...
Hyatt Place San Antonio - Riverwalk

Hyatt Place San Antonio - Riverwalk

3 out of 5
601 S Saint Marys St, San Antonio, TX
12.71 km from Medical Center District
Book a stay at this family-friendly hotel in San Antonio. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
Hotel Contessa

Hotel Contessa

4 out of 5
306 W Market Street, San Antonio, TX
12.51 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy free WiFi, an outdoor pool, and a full-service spa. Our guests praise the breakfast and the pool in our reviews. ...
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive, San Antonio, TX
11.28 km from Medical Center District
Stay at this 3.5-star family-friendly hotel in San Antonio. Enjoy free WiFi, free parking, and a lazy river. Our guests praise the pool and the helpful staff ...
Omni La Mansion del Rio

Omni La Mansion del Rio

4 out of 5
112 College St, San Antonio, TX
12.28 km from Medical Center District
Stay at this 4-star spa hotel in San Antonio. Enjoy a full-service spa, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff in ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Wed, Jul 2 - Tue, Jul 8
ATL
Hartsfield-Jackson Atlanta Intl.
SAT
San Antonio Intl.
$100 Roundtrip, found 6 days ago
$100
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Wed, Jul 2 from Hartsfield-Jackson Atlanta Intl. to San Antonio Intl., returning Tue, Jul 8, priced at $100 found 6 days ago
Spirit Airlines
Wed, Jun 25 - Wed, Jul 9
LAX
Los Angeles Intl.
SAT
San Antonio Intl.
$120 Roundtrip, found 1 day ago
$120
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Wed, Jun 25 from Los Angeles Intl. to San Antonio Intl., returning Wed, Jul 9, priced at $120 found 1 day ago
Spirit Airlines
Tue, Jun 24 - Mon, Jun 30
EWR
Newark Liberty Intl. Airport
SAT
San Antonio Intl.
$190 Roundtrip, found 6 days ago
$190
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Tue, Jun 24 from Newark Liberty Intl. Airport to San Antonio Intl., returning Mon, Jun 30, priced at $190 found 6 days ago
American Airlines
Thu, Jul 10 - Mon, Jul 14
SEA
Seattle - Tacoma Intl.
SAT
San Antonio Intl.
$195 Roundtrip, found 1 day ago
$195
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Jul 10 from Seattle - Tacoma Intl. to San Antonio Intl., returning Mon, Jul 14, priced at $195 found 1 day ago