2026 3 Star Hotels in Otay Mesa

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Featured Otay Mesa 3 Star Hotels

Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
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Best Western Seven Seas
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
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Handlery Hotel
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 out of 5
1055 1st Ave San Diego CA
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The Bristol Hotel San Diego
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3 out of 5
543 Hotel Circle S San Diego CA
Days Inn by Wyndham San Diego Hotel Circle
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
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The DEXTRO Little Italy, BW Premier Collection
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
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The Sofia Hotel
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr San Diego CA
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The Dana on Mission Bay
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr San Diego CA
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Bay Club Hotel & Marina
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

3 out of 5
2051 Shelter Island Dr San Diego CA
Fully refundableReserve now, pay when you stay
Best Western Plus Island Palms Hotel & Marina
See all 4,877 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.