Uptown Vacation Packages for 2025

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Top Hotel Deals

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St, St. Louis, MO
17.68 km from Uptown
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street, St. Louis, MO
17.8 km from Uptown
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the pool ...
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
30.11 km from Uptown
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
The Arch Convention Hotel

The Arch Convention Hotel

3.5 out of 5
811 N 9th Street, St. Louis, MO
17.92 km from Uptown
Stay at this 3.5-star business-friendly hotel in St. Louis. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful ...
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St, St. Louis, MO
17.93 km from Uptown
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the bar and the helpful ...
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave, St. Louis, MO
17.9 km from Uptown
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise ...
Moonrise Hotel

Moonrise Hotel

4 out of 5
6177 Delmar Blvd, St. Louis, MO
26.77 km from Uptown
Stay at this 4-star boutique hotel in St. Louis. Enjoy free WiFi, free parking, and 2 bars/lounges. Our guests praise the restaurant and the bar in our reviews. ...
Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street, St. Louis, MO
19.65 km from Uptown
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the restaurant ...
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street, St. Louis, MO
18.79 km from Uptown
Stay at this 4.5-star luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd, St. Louis, MO
28.19 km from Uptown
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
Forest Park Hotel by MDR

Forest Park Hotel by MDR

3 out of 5
5915 Wilson Ave, St. Louis, MO
26.25 km from Uptown
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the ...
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave, St. Louis, MO
30.32 km from Uptown
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Popular attractions St. Louis Zoo and Forest Park ...
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

3 out of 5
201 S 20th St, St. Louis, MO
19.48 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Pear Tree Inn St. Louis Convention Center

Pear Tree Inn St. Louis Convention Center

3 out of 5
711 N Broadway, St. Louis, MO
17.57 km from Uptown
Stay at this 3-star business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

4 out of 5
1 S Broadway, St. Louis, MO
17.98 km from Uptown
Stay at this 4-star business-friendly hotel in St. Louis. Enjoy 3 restaurants, 3 bars/lounges, and a rooftop terrace. Our guests praise the clean rooms in our ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, Oct 8 - Sat, Oct 11
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$103 Roundtrip, found 3 days ago
$103
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Wed, Oct 8 from Denver Intl. to Lambert-St. Louis Intl., returning Sat, Oct 11, priced at $103 found 3 days ago
American Airlines
Wed, Oct 15 - Sun, Oct 19
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$175 Roundtrip, found 6 days ago
$175
Roundtrip
found 6 days ago
Select American Airlines flight, departing Wed, Oct 15 from Tampa Intl. to Lambert-St. Louis Intl., returning Sun, Oct 19, priced at $175 found 6 days ago
Spirit Airlines
Tue, Oct 14 - Tue, Oct 21
TPA
Tampa Intl.
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 6 days ago
$185
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Tue, Oct 14 from Tampa Intl. to Lambert-St. Louis Intl., returning Tue, Oct 21, priced at $185 found 6 days ago
Delta
Fri, Sep 12 - Mon, Sep 15
DAL
Love Field
STL
Lambert-St. Louis Intl.
$238 Roundtrip, found 1 day ago
$238
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, Sep 12 from Love Field to Lambert-St. Louis Intl., returning Mon, Sep 15, priced at $238 found 1 day ago
United
Tue, Sep 16 - Sat, Sep 20
EWR
Newark Liberty Intl. Airport
STL
Lambert-St. Louis Intl.
$259 Roundtrip, found 3 days ago
$259
Roundtrip
found 3 days ago
Select United flight, departing Tue, Sep 16 from Newark Liberty Intl. Airport to Lambert-St. Louis Intl., returning Sat, Sep 20, priced at $259 found 3 days ago