Uptown Vacation Packages for 2026

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Top Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
30.11 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street St. Louis MO
17.8 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and 2 hot tubs. Our guests praise the breakfast and the pool in our ...
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
18.79 km from Uptown
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the pool and the restaurant in our ...
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
17.68 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 3 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean ...
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd St. Louis MO
28.19 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean ...
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

3 out of 5
201 S 20th St St. Louis MO
19.48 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave St. Louis MO
18.22 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the bar and the helpful ...
Home2 Suites by Hilton St. Louis Downtown

Home2 Suites by Hilton St. Louis Downtown

3 out of 5
1221 Locus Street St. Louis MO
18.44 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free breakfast, valet parking (surcharge), and a 24-hour front desk. Our guests praise the helpful ...
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave St. Louis MO
17.9 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise ...
Hotel Indigo St Louis - Central West End by IHG

Hotel Indigo St Louis - Central West End by IHG

3.5 out of 5
4630 Lindell St. Louis MO
23.6 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, 4 restaurants, and breakfast (surcharge). Our guests praise the helpful staff and ...
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St St. Louis MO
17.93 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark

4 out of 5
1 S Broadway St. Louis MO
17.98 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy 3 restaurants, 3 bars/lounges, and a rooftop terrace. Our guests praise the clean rooms in our ...
Forest Park Hotel by MDR

Forest Park Hotel by MDR

3 out of 5
5915 Wilson Ave St. Louis MO
26.21 km from Uptown
Book a stay at this business-friendly hotel in St. Louis. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the ...
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St St. Louis MO
18.38 km from Uptown
Book a stay at this luxury hotel in St. Louis. Enjoy breakfast (surcharge), 24-hour room service, and valet parking (surcharge). Our guests praise the helpful ...
Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

3 out of 5
823-827 Washington Avenue St. Louis MO
17.97 km from Uptown
Stay at this hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the clean rooms in our reviews. ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Wed, Apr 15 - Wed, Apr 29
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$76 Roundtrip, just found
$76
Roundtrip
just found
Select Frontier Airlines flight, departing Wed, Apr 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Apr 29, priced at $76 just found
Southwest Airlines
Wed, Apr 15 - Wed, Apr 29
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$177 Roundtrip, just found
$177
Roundtrip
just found
Select Southwest Airlines flight, departing Wed, Apr 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Apr 29, priced at $177 just found
United
Wed, Apr 29 - Wed, May 6
DEN
Denver Intl.
STL
Lambert-St. Louis Intl.
$185 Roundtrip, found 12 hours ago
$185
Roundtrip
found 12 hours ago
Select United flight, departing Wed, Apr 29 from Denver Intl. to Lambert-St. Louis Intl., returning Wed, May 6, priced at $185 found 12 hours ago
Delta
Wed, Apr 15 - Wed, Apr 29
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$197 Roundtrip, just found
$197
Roundtrip
just found
Select Delta flight, departing Wed, Apr 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Apr 29, priced at $197 just found
American Airlines
Wed, Apr 15 - Wed, Apr 29
ATL
Hartsfield-Jackson Atlanta Intl.
STL
Lambert-St. Louis Intl.
$217 Roundtrip, just found
$217
Roundtrip
just found
Select American Airlines flight, departing Wed, Apr 15 from Hartsfield-Jackson Atlanta Intl. to Lambert-St. Louis Intl., returning Wed, Apr 29, priced at $217 just found