21C Museum Hotel St Louis
Choose dates to view prices
Photo gallery for 21C Museum Hotel St Louis





A short walk from St. Louis Union Station and Enterprise Center, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services, and a bar. For some rest and relaxation, visit the steam room. In addition to a gym and a business center, guests can connect to free in-room WiFi.
Reviews
9.0 out of 10
Wonderful
Popular amenities
Room options
Check availability for these dates
Available filters for rooms
Showing 10 of 10 rooms
View all photos for Deluxe Room, 1 King Bed

Deluxe Room, 1 King Bed
9.2 out of 10
Wonderful
(127 reviews)
View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds
9.4 out of 10
Exceptional
(40 reviews)
View all photos for Room (Bunk Bed)

Room (Bunk Bed)
8.6 out of 10
Excellent
(9 reviews)
View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds
9.0 out of 10
Wonderful
(2 reviews)
View all photos for Deluxe Room, Accessible (Accessible)

Deluxe Room, Accessible (Accessible)
10.0 out of 10
Exceptional
(1 review)
View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)
View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)
View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed
9.4 out of 10
Exceptional
(3 reviews)
View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible
View all photos for Deluxe Suite, 1 Double Bed, Accessible

Deluxe Suite, 1 Double Bed, Accessible
About the neighborhood

1528 Locust street, St. Louis, MO, 63103
What's nearby
Washington Avenue Historic District2 min walk - 0.1 miles
City Museum5 min walk - 0.3 miles
St. Louis Union Station8 min walk - 0.4 miles
Enterprise Center8 min walk - 0.5 miles- St. Louis Aquarium at Union Station11 min walk - 0.6 miles
Getting around
- 8th and Pine Station13 min walk
- St. Louis Gateway Station14 min walk
- St. Louis Lambert Intl. Airport (STL)24 min drive
Restaurants
- Rosalita's Cantina6 min walk
- Hair of the Dog7 min walk
- Imo's Pizza Headquarters & Retail Store7 min walk
- Medina Grill5 min walk
- Good Press1 min walk
Similar properties

Hyatt Regency St. Louis at The Arch
Downtown St. Louis
Hyatt Regency St. Louis at The Arch
- Pet friendly
- Free WiFi
- Restaurant
- Air conditioning
8.6 out of 10, Excellent, 4,220 reviews
Property amenities
Room amenities
Policies
Important information
Fees
You'll be asked to pay the following charges at the property. Fees may include applicable taxes:
- Service fee: USD 5 per accommodation, per stay
We have included all charges provided to us by the property.
Optional extras
- Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
- Valet parking fee: USD 55 per day (in/out privileges)
- Pet fee: USD 100 per accommodation, per stay
- Service animals are exempt from fees
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
You need to know
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector, and outdoor lighting
We should mention
Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)
Frequently asked questions
Have a question?
BetaGet instant answers with AI powered search of property information and reviews.
Reviews
21C Museum Hotel St Louis Reviews
9.0
Wonderful
9.2
Cleanliness
9.0
Amenities
9.0
Staff & service
9.2
Property conditions & facilities
Reviews
Verified review
Aug 24, 2026
Liked: Staff & service, amenities
Stayed 1 night in Aug 2026
Verified review
10/10 Excellent
Ryan
Aug 12, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Ryan
Stayed 3 nights in Jul 2026
Verified review
10/10 Excellent
Jasnyne
Aug 25, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Jasnyne
Stayed 1 night in Aug 2026
Verified review
8/10 Good
kyle
Aug 10, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
kyle
Stayed 2 nights in Aug 2026
Verified review
10/10 Excellent
david
Aug 11, 2026
Liked: Cleanliness, staff & service, property conditions & facilities
david
Stayed 3 nights in Aug 2026
Verified review
10/10 Excellent
Keaunte
Jul 25, 2026
Liked: Cleanliness, staff & service, property conditions & facilities
Keaunte
Stayed 1 night in Jul 2026
Verified review
10/10 Excellent
David
Aug 18, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
David
Stayed 1 night in Aug 2026
Verified review
10/10 Excellent
Joe
Jul 12, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Joe
Stayed 1 night in Feb 2026
Verified review
10/10 Excellent
Isaac
Aug 30, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Isaac
Stayed 2 nights in Aug 2026
Verified review
10/10 Excellent
Katrina
Jun 9, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Katrina
Stayed 2 nights in Mar 2026
Verified review
10/10 Excellent
Gretchen
Jul 19, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities




Gretchen
Stayed 1 night in Jul 2026
Verified review
10/10 Excellent
Michele
Jun 11, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Michele
Stayed 1 night in Jun 2026
Verified review
10/10 Excellent
Matthew
May 28, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Matthew
Stayed 1 night in May 2026
Verified review
10/10 Excellent
Amanda
Jul 18, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities




Amanda
Stayed 1 night in Jul 2026
Verified review
10/10 Excellent
Evan
Jun 15, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Evan
Stayed 1 night in Jun 2026
Verified review
10/10 Excellent
Meeta
May 30, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Meeta
Stayed 3 nights in May 2026
Verified review
10/10 Excellent
Lauren
Jun 6, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Lauren
Stayed 3 nights in May 2026
Verified review
10/10 Excellent
Jenlyn
May 20, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Jenlyn
Stayed 2 nights in May 2026
Verified review
10/10 Excellent
ADIS
Jun 15, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
ADIS
Stayed 1 night in Jun 2026
Verified review
10/10 Excellent
Elizabeth
May 21, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Elizabeth
Stayed 1 night in May 2026
Verified review
10/10 Excellent
Porsha
Jun 5, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Porsha
Stayed 1 night in Apr 2026
Verified review
10/10 Excellent
Erika
Jun 2, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities


Erika
Stayed 2 nights in May 2026
Verified review
10/10 Excellent
Emily
Jun 10, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Emily
Stayed 1 night in Jun 2026
Verified review
6/10 Okay
julie
Jul 28, 2026
Liked: Staff & service
julie
Stayed 1 night in Jul 2026
Verified review
10/10 Excellent
Julie
May 31, 2026
Liked: Cleanliness, staff & service, amenities, property conditions & facilities


Julie
Stayed 1 night in May 2026








