
South San Diego Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
South San Diego Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.

Town and Country San Diego
Mission Valley
Save 100% on your flight
Price was $799, price is now $481 per person
$481
per person
Dec 4 - Dec 9
found 21 hours ago
Roundtrip flight included
Denver (DEN) to San Diego (SAN)
Stay at this 4-star golf hotel in San Diego. Enjoy free WiFi, 2 outdoor pools, and 2 restaurants. Our guests praise the pool and the helpful staff in our reviews. Popular attractions San Diego Zoo and Balboa Park are located nearby.

Margaritaville Hotel San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $1,206, price is now $642 per person
$642
per person
Dec 9 - Dec 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Stay at this 4-star hotel in San Diego. Enjoy a rooftop terrace, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.

The Sofia Hotel
Downtown San Diego
Save 100% on your flight
Price was $1,081, price is now $595 per person
$595
per person
Dec 9 - Dec 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Stay at this 3.5-star historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.

Sand Castle Inn
Save 100% on your flight
Price was $1,179, price is now $656 per person
$656
per person
Dec 9 - Dec 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Book a stay at this beach motel in Imperial Beach. Enjoy free WiFi, free parking, and laundry facilities. Our guests praise the helpful staff in our reviews. Popular attractions San Diego Bay and Las Americas Premium Outlets are located nearby.

Sentral Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $1,118, price is now $673 per person
$673
per person
Dec 9 - Dec 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Stay at this 3-star hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and a 24-hour fitness center. Popular attractions Petco Park and Port of San Diego are located nearby.

Hilton San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $1,439, price is now $873 per person
$873
per person
Dec 9 - Dec 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Stay at this 4-star business-friendly hotel in San Diego. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and USS Midway Museum are located nearby.
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See all available trips from Columbus to South San Diego
View all tripsTop Hotel Deals

Hilton San Diego Mission Valley
901 Camino Del Rio S, San Diego, CA
22.79 km from city center
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...

Hampton Inn & Suites by Hilton San Diego SeaWorld
3888 Greenwood St, San Diego, CA
25.03 km from city center
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Mission ...

Hard Rock Hotel San Diego
207 5th Ave, San Diego, CA
18.25 km from city center
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...

InterContinental San Diego by IHG
901 Bayfront Court, San Diego, CA
19.74 km from city center
Stay at this 4-star business-friendly hotel in San Diego. Enjoy 2 restaurants, 3 bars/lounges, and a rooftop terrace. Our guests praise the helpful staff and ...

Courtyard by Marriott San Diego Downtown Little Italy
1646 Front St, San Diego, CA
19.76 km from city center
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...

Legacy Resort Hotel & Spa
875 Hotel Circle South, San Diego, CA
23.17 km from city center
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...

Handlery Hotel
950 Hotel Cir N, San Diego, CA
23.39 km from city center
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
19.96 km from city center
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...

Loews Coronado Bay Resort
4000 Coronado Bay Rd, Coronado, CA
11.75 km from city center
Stay at this 4-star beach hotel in Coronado. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...

The Dana on Mission Bay
1710 W Mission Bay Dr, San Diego, CA
27.99 km from city center
Stay at this 3.5-star hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular ...

Hotel del Coronado, Curio Collection by Hilton
1500 Orange Ave, Coronado, CA
17.73 km from city center
Stay at this 4-star beach resort in Coronado. Enjoy free WiFi, 6 restaurants, and a private beach. Our guests praise the helpful staff and the property condition ...

Comfort Inn Sea World Area
3880 Greenwood St, San Diego, CA
25.02 km from city center
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue, San Diego, CA
19.63 km from city center
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Don't see what you're looking for?
See all available properties in South San Diego
View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Sat, Nov 22 - Tue, Dec 2
DEN
Denver Intl.
SAN
San Diego Intl.
$68 Roundtrip, found 3 days ago
$68
Roundtrip
found 3 days ago

Tue, Nov 11 - Sat, Nov 15
SFO
San Francisco Intl.
SAN
San Diego Intl.
$93 Roundtrip, found 6 days ago
$93
Roundtrip
found 6 days ago

Tue, Nov 11 - Sat, Nov 15
SFO
San Francisco Intl.
CLD
McClellan-Palomar
$187 Roundtrip, found 6 days ago
$187
Roundtrip
found 6 days ago

Thu, Jan 8 - Fri, Jan 23
BOS
Logan Intl.
SAN
San Diego Intl.
$217 Roundtrip, found 3 days ago
$217
Roundtrip
found 3 days ago

Tue, Jan 13 - Sat, Jan 17
MSP
Minneapolis - St. Paul Intl.
SAN
San Diego Intl.
$239 Roundtrip, found 2 days ago
$239
Roundtrip
found 2 days ago

