Otay Mesa West Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
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Otay Mesa West Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Coronado Beach Resort
Historic Downtown Coronado
Save 100% on your flight
Price was $1,194, price is now $754 per person
$754
per person
Nov 3 - Nov 8
found 1 day ago
Roundtrip flight included
Chicago (ORD) to San Diego (SAN)
Stay at this 3-star condo in Coronado. Enjoy free WiFi, a 24-hour fitness center, and parking (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Hotel del Coronado and Petco Park are located nearby.
Margaritaville Hotel San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $2,453, price is now $1,472 per person
$1,472
per person
Oct 11 - Oct 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
Stay at this 4-star hotel in San Diego. Enjoy a rooftop terrace, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
The Sofia Hotel
Downtown San Diego
Save 100% on your flight
Price was $2,310, price is now $1,486 per person
$1,486
per person
Oct 11 - Oct 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
Stay at this 3.5-star historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.
The DEXTRO Little Italy, BW Premier Collection
Downtown San Diego
Save 100% on your flight
Price was $1,557, price is now $1,016 per person
$1,016
per person
Oct 11 - Oct 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.
Estancia La Jolla Hotel & Spa
La Jolla Farms
Save 100% on your flight
Price was $1,793, price is now $1,188 per person
$1,188
per person
Nov 3 - Nov 9
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Stay at this 4-star spa hotel in La Jolla. Enjoy a full-service spa, 4 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Torrey Pines Golf Course and La Jolla Beach are located nearby.
The Dana on Mission Bay
Save 100% on your flight
Price was $1,598, price is now $1,111 per person
$1,111
per person
Oct 11 - Oct 19
found 1 day ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
Stay at this 3.5-star hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions Mission Beach and Mission Bay are located nearby.
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Manchester Grand Hyatt San Diego
1 Market Pl, San Diego, CA
18.19 km from Otay Mesa West
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
19.21 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Palihotel San Diego Gaslamp Quarter
830 Sixth Avenue, San Diego, CA
18.09 km from Otay Mesa West
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in ...
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue, San Diego, CA
19.06 km from Otay Mesa West
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Bay Club Hotel & Marina
2131 Shelter Island Dr, San Diego, CA
22.11 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant ...
Hotel del Coronado, Curio Collection by Hilton
1500 Orange Ave, Coronado, CA
16.28 km from Otay Mesa West
Stay at this 4-star beach resort in Coronado. Enjoy free WiFi, 6 restaurants, and a private beach. Our guests praise the helpful staff and the property condition ...
Handlery Hotel
950 Hotel Cir N, San Diego, CA
23.14 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
Hard Rock Hotel San Diego
207 5th Ave, San Diego, CA
17.51 km from Otay Mesa West
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
The Dana on Mission Bay
1710 W Mission Bay Dr, San Diego, CA
27.07 km from Otay Mesa West
Stay at this 3.5-star hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular ...
Embassy Suites by Hilton San Diego Bay Downtown
601 Pacific Hwy, San Diego, CA
18.44 km from Otay Mesa West
Book a stay at this family-friendly hotel in San Diego. Enjoy free breakfast, room service, and a fitness center. Our guests praise the breakfast and the helpful ...
Wyndham Garden San Diego Near SeaWorld
3737 Sports Arena Blvd, San Diego, CA
24.78 km from Otay Mesa West
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, parking (surcharge), and a 24-hour front desk. Our guests praise the helpful staff ...
Best Western Plus Marina Gateway Hotel
800 Bay Marina Dr, National City, CA
10.5 km from Otay Mesa West
Stay at this 3.5-star eco-certified hotel in National City. Enjoy free WiFi, free parking, and a golf course. Our guests praise the pool and the restaurant in ...
San Diego Mission Bay Resort
1775 E Mission Bay Dr, San Diego, CA
26.68 km from Otay Mesa West
Stay at this 4-star beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Sat, Sep 27 - Mon, Oct 6
SFO
San Francisco Intl.
SAN
San Diego Intl.
$68 Roundtrip, found 4 days ago
$68
Roundtrip
found 4 days ago
Wed, Oct 1 - Sun, Oct 5
ORD
O'Hare Intl.
SAN
San Diego Intl.
$151 Roundtrip, found 20 hours ago
$151
Roundtrip
found 20 hours ago
Tue, Nov 4 - Tue, Nov 11
DEN
Denver Intl.
CLD
McClellan-Palomar
$159 Roundtrip, found 2 days ago
$159
Roundtrip
found 2 days ago
Sat, Oct 4 - Tue, Oct 7
BOS
Logan Intl.
SAN
San Diego Intl.
$232 Roundtrip, found 2 days ago
$232
Roundtrip
found 2 days ago