Otay Mesa West Vacation Packages for 2025

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Top Hotel Deals

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
23.14 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
19.21 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
18.19 km from Otay Mesa West
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
27.07 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in ...
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4 out of 5
333 W Harbor Dr, San Diego, CA
17.95 km from Otay Mesa West
Book a stay at this spa hotel in San Diego. Enjoy 2 outdoor pools, a full-service spa, and 5 restaurants. Our guests praise the pool and the helpful staff in ...
The Dextro Hotel, BW Premier Collection

The Dextro Hotel, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
19.06 km from Otay Mesa West
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

Best Western Inn & Suites San Diego – Zoo/SeaWorld Area

2.5 out of 5
2485 Hotel Circle Place, San Diego, CA
23.94 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the breakfast and the helpful ...
Hilton San Diego Bayfront

Hilton San Diego Bayfront

4 out of 5
1 Park Blvd, San Diego, CA
17.17 km from Otay Mesa West
Stay at this 4-star spa hotel in San Diego. Enjoy a full-service spa, 2 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the helpful staff ...
Lafayette Hotel & Club

Lafayette Hotel & Club

4 out of 5
2223 El Cajon Blvd, San Diego, CA
21.31 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
Hampton Inn San Diego/Mission Valley

Hampton Inn San Diego/Mission Valley

2.5 out of 5
2151 Hotel Circle South, San Diego, CA
23.45 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a 24-hour fitness center. Our guests praise the breakfast and ...
The Little Italy Hotel Downtown San Diego

The Little Italy Hotel Downtown San Diego

4 out of 5
1646 Front St, San Diego, CA
19.15 km from Otay Mesa West
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the helpful staff in our reviews. ...
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr, San Diego, CA
22.11 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant ...
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

4 out of 5
601 Pacific Hwy, San Diego, CA
18.44 km from Otay Mesa West
Book a stay at this family-friendly hotel in San Diego. Enjoy free breakfast, room service, and a fitness center. Our guests praise the breakfast and the helpful ...
Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

4 out of 5
1441 Quivira Rd, San Diego, CA
27.22 km from Otay Mesa West
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in our ...
Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

4 out of 5
901 Camino Del Rio S, San Diego, CA
22.79 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Sun, Aug 10 - Thu, Aug 14
SFO
San Francisco Intl.
SAN
San Diego Intl.
$57 Roundtrip, found 2 days ago
$57
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sun, Aug 10 from San Francisco Intl. to San Diego Intl., returning Thu, Aug 14, priced at $57 found 2 days ago
Spirit Airlines
Sat, Aug 16 - Sat, Aug 23
ORD
O'Hare Intl.
SAN
San Diego Intl.
$122 Roundtrip, found 6 days ago
$122
Roundtrip
found 6 days ago
Select Spirit Airlines flight, departing Sat, Aug 16 from O'Hare Intl. to San Diego Intl., returning Sat, Aug 23, priced at $122 found 6 days ago
Alaska Airlines
Sat, Nov 15 - Sat, Nov 22
SEA
Seattle - Tacoma Intl.
SAN
San Diego Intl.
$157 Roundtrip, found 4 days ago
$157
Roundtrip
found 4 days ago
Select Alaska Airlines flight, departing Sat, Nov 15 from Seattle - Tacoma Intl. to San Diego Intl., returning Sat, Nov 22, priced at $157 found 4 days ago
American Airlines
Thu, Sep 4 - Sat, Sep 6
DEN
Denver Intl.
CLD
McClellan-Palomar
$168 Roundtrip, found 5 days ago
$168
Roundtrip
found 5 days ago
Select American Airlines flight, departing Thu, Sep 4 from Denver Intl. to McClellan-Palomar, returning Sat, Sep 6, priced at $168 found 5 days ago
Hawaiian Airlines
Tue, Oct 21 - Tue, Oct 28
PAE
Seattle Paine Field Intl. Airport
SAN
San Diego Intl.
$177 Roundtrip, found 2 hours ago
$177
Roundtrip
found 2 hours ago
Select Hawaiian Airlines flight, departing Tue, Oct 21 from Seattle Paine Field Intl. Airport to San Diego Intl., returning Tue, Oct 28, priced at $177 found 2 hours ago