Otay Mesa West Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
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Otay Mesa West Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel
Downtown San Diego
Save 100% on your flight
Price was $895, price is now $513 per person
$513
per person
Dec 10 - Dec 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Stay at this 3.5-star historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.
Margaritaville Hotel San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $1,250, price is now $687 per person
$687
per person
Jan 15 - Jan 20
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Stay at this 4-star hotel in San Diego. Enjoy a rooftop terrace, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
Sand Castle Inn
Save 100% on your flight
Price was $1,049, price is now $596 per person
$596
per person
Dec 10 - Dec 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Book a stay at this beach motel in Imperial Beach. Enjoy free WiFi, free parking, and laundry facilities. Our guests praise the helpful staff in our reviews. Popular attractions San Diego Bay and Las Americas Premium Outlets are located nearby.
Hilton San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $1,153, price is now $709 per person
$709
per person
Dec 10 - Dec 17
found 1 day ago
Roundtrip flight included
Boston (BOS) to San Diego (SAN)
Stay at this 4-star business-friendly hotel in San Diego. Enjoy breakfast (surcharge), a 24-hour fitness center, and WiFi (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions Petco Park and USS Midway Museum are located nearby.
Palihotel San Diego Gaslamp Quarter
Downtown San Diego
Save 100% on your flight
Price was $1,391, price is now $864 per person
$864
per person
Jan 15 - Jan 21
found 7 hours ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in our reviews. Popular attractions Petco Park and Port of San Diego are located nearby.
The Guild Hotel, San Diego, A Tribute Portfolio Hotel by Marriott
Downtown San Diego
Save 100% on your flight
Price was $1,553, price is now $992 per person
$992
per person
Dec 4 - Dec 11
found 19 hours ago
Roundtrip non-stop flight included
Boston (BOS) to San Diego (SAN)
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free breakfast, a 24-hour fitness center, and valet parking (surcharge). Our guests praise the bar and the helpful staff in our reviews. Popular attractions Port of San Diego and USS Midway Museum are located nearby.
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Hampton Inn & Suites by Hilton San Diego SeaWorld
3888 Greenwood St, San Diego, CA
24.32 km from Otay Mesa West
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free breakfast, free WiFi, and a fitness center. Popular attractions Mission Bay and Mission ...
Handlery Hotel
950 Hotel Cir N, San Diego, CA
23.14 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...
Comfort Inn San Diego Airport At The Harbor
23.12 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free breakfast, a rooftop terrace, and parking (surcharge). Our guests praise the helpful staff ...
Manchester Grand Hyatt San Diego
1 Market Pl, San Diego, CA
18.19 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...
Hilton San Diego Mission Valley
901 Camino Del Rio S, San Diego, CA
22.79 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
Pendry San Diego
550 J Street, San Diego, CA
17.66 km from Otay Mesa West
Stay at this 5-star luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Hard Rock Hotel San Diego
207 5th Ave, San Diego, CA
17.51 km from Otay Mesa West
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...
Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
19.21 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
The Dana on Mission Bay
1710 W Mission Bay Dr, San Diego, CA
27.07 km from Otay Mesa West
Stay at this 3.5-star hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular ...
Courtyard by Marriott San Diego Downtown Little Italy
1646 Front St, San Diego, CA
19.15 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
Legacy Resort Hotel & Spa
875 Hotel Circle South, San Diego, CA
22.93 km from Otay Mesa West
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue, San Diego, CA
19.06 km from Otay Mesa West
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
InterContinental San Diego by IHG
901 Bayfront Court, San Diego, CA
18.96 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy 2 restaurants, 3 bars/lounges, and a rooftop terrace. Our guests praise the helpful staff and ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Sun, Feb 8 - Sat, Feb 14
ORD
O'Hare Intl.
SAN
San Diego Intl.
$126 Roundtrip, found 3 days ago
$126
Roundtrip
found 3 days ago
Fri, Feb 20 - Mon, Feb 23
ORD
O'Hare Intl.
SAN
San Diego Intl.
$127 Roundtrip, found 5 days ago
$127
Roundtrip
found 5 days ago
Tue, Feb 17 - Fri, Feb 20
ORD
O'Hare Intl.
SAN
San Diego Intl.
$153 Roundtrip, found 5 days ago
$153
Roundtrip
found 5 days ago
Wed, Dec 17 - Tue, Jan 6
PDX
Portland Intl.
SAN
San Diego Intl.
$157 Roundtrip, found 1 hour ago
$157
Roundtrip
found 1 hour ago
Wed, Nov 12 - Mon, Nov 17
DFW
Dallas-Fort Worth Intl.
SAN
San Diego Intl.
$161 Roundtrip, found 3 days ago
$161
Roundtrip
found 3 days ago