Santo Spirito Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Santo Spirito Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Aurum Firenze
Historic Centre of Florence
Price was $1,243, price is now $865 per person
$865
per person
Nov 11 - Nov 17
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Florence (FLR)
Stay at this 4-star hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Cathedral of Santa Maria del Fiore and Ponte Vecchio are located nearby.
Aurum Uffizi
Historic Centre of Florence
Price was $1,438, price is now $921 per person
$921
per person
Dec 3 - Dec 10
found 14 hours ago
Roundtrip flight included
Knoxville (TYS) to Florence (FLR)
Stay at this 4-star hotel in Florence. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Uffizi Gallery and Ponte Vecchio are located nearby.
The Moon Boutique Hotel & Spa
Historic Centre of Florence
Save 100% on your flight
Price was $1,812, price is now $1,172 per person
$1,172
per person
Nov 11 - Nov 17
found 1 day ago
Roundtrip flight included
Chicago (ORD) to Florence (FLR)
Stay at this 4-star spa hotel in Florence. Enjoy free WiFi, a full-service spa, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Cathedral of Santa Maria del Fiore and Ponte Vecchio are located nearby.
Eurostars Florence Boutique
Historic Centre of Florence
Price was $1,608, price is now $1,147 per person
$1,147
per person
Dec 3 - Dec 10
found 13 hours ago
Roundtrip flight included
Knoxville (TYS) to Florence (FLR)
Stay at this 4-star boutique hotel in Florence. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Popular attractions Uffizi Gallery and Cathedral of Santa Maria del Fiore are located nearby.
Hotel Berchielli
Historic Centre of Florence
Price was $2,204, price is now $1,599 per person
$1,599
per person
Dec 3 - Dec 10
found 13 hours ago
Roundtrip flight included
Knoxville (TYS) to Florence (FLR)
Stay at this 4-star business-friendly hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Ponte Vecchio and Uffizi Gallery are located nearby.
Villa Cora
Oltrarno
Save 100% on your flight
Price was $3,106, price is now $2,270 per person
$2,270
per person
Dec 3 - Dec 10
found 13 hours ago
Roundtrip flight included
Knoxville (TYS) to Florence (FLR)
Stay at this 5-star luxury hotel in Florence. Enjoy free WiFi, free parking, and a full-service spa. Popular attractions Ponte Vecchio and Uffizi Gallery are located nearby.
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Hotel Horto Convento
Viale Ariosto, 13, Florence, FI
0.42 km from Santo Spirito
Stay at this 4-star hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. ...
Palazzo Mannaioni Suites
Via Maffia 9 - 17r, Florence, FI
0.93 km from Santo Spirito
Stay at this 4-star residence in Florence. Enjoy free WiFi, concierge services, and satellite TV channels. Our guests praise the helpful staff in our reviews. ...
UNA Hotels Vittoria Firenze
Via Pisana 59, Florence, FI
0.49 km from Santo Spirito
Stay at this 4-star boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
La Torre Del Cestello
Via Borgo San Frediano, 8, Florence, FI
0.86 km from Santo Spirito
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Uffizi Gallery ...
Casa Santo Nome di Gesù
Piazza del Carmine, 21, Florence, FI
0.68 km from Santo Spirito
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
Hotel Firenze 2000
Viale Raffaello Sanzio, 16, Florence, FI
0.43 km from Santo Spirito
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Popular attractions Ponte Vecchio and Uffizi Gallery are located ...
Foresteria Valdese di Firenze - Casa per Ferie
Via dei Serragli 49, Florence, FI
0.78 km from Santo Spirito
Stay at this property in Florence. Enjoy free WiFi, 2 meeting rooms, and satellite TV channels. Our guests praise the helpful staff and the clean rooms in our ...
Hostel Santa Monaca
Via Santa Monaca 6, Florence, FI
0.78 km from Santo Spirito
Stay at this hostel in Florence. Enjoy free WiFi, daily housekeeping, and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Uffizi Gallery ...
1900 Artevita
Viale Raffaello Sanzio 2, Florence, FI
0.49 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free WiFi, breakfast (surcharge), and housekeeping. Popular attractions Ponte Vecchio and Uffizi Gallery are located ...
Palazzo Oliveto
Via Monte Oliveto, 32, Florence, FI
0.3 km from Santo Spirito
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and a garden. Popular attractions Ponte Vecchio and Uffizi Gallery are located nearby.
Residenza D'Epoca Al Numero 8
Via Borgo San Frediano n. 8, Florence, FI
0.86 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular ...
La Fonderia Firenze
Via della Fonderia 65/A, Florence, FI
0.65 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free breakfast, free WiFi, and a garden. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions ...
B&B Mia Palace
Via della Fonderia 8, Florence, FI
0.66 km from Santo Spirito
Stay at this affittacamere in Florence. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Ponte Vecchio and Cathedral of Santa ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Wed, Nov 19 - Thu, Nov 27
JFK
John F. Kennedy Intl.
FLR
Peretola
$384 Roundtrip, found 7 hours ago
$384
Roundtrip
found 7 hours ago
Mon, Nov 24 - Wed, Dec 3
JFK
John F. Kennedy Intl.
FLR
Peretola
$390 Roundtrip, found 7 hours ago
$390
Roundtrip
found 7 hours ago
Wed, Nov 19 - Wed, Dec 3
JFK
John F. Kennedy Intl.
FLR
Peretola
$409 Roundtrip, found 7 hours ago
$409
Roundtrip
found 7 hours ago
Sun, Nov 23 - Thu, Nov 27
JFK
John F. Kennedy Intl.
FLR
Peretola
$477 Roundtrip, found 7 hours ago
$477
Roundtrip
found 7 hours ago
Wed, Nov 19 - Sat, Nov 29
JFK
John F. Kennedy Intl.
FLR
Peretola
$860 Roundtrip, found 7 hours ago
$860
Roundtrip
found 7 hours ago