Eastern Panama Vacation Packages for 2026
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Eastern Panama Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City
San Francisco
$924
per person
Nov 13 - Nov 18
found 24 hours ago
Roundtrip non-stop flight included
St. Louis (STL) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free WiFi, and free valet parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Central Hotel Panama Casco Viejo
Casco Viejo
$1,230
per person
Nov 6 - Nov 11
found 1 day ago
Roundtrip non-stop flight included
St. Louis (STL) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
Exceptionally nice staff. Great location. Pretty old hotel.
Reviewed on Sep 29, 2026
Megapolis Hotel Panamá
San Francisco
$991
per person
Nov 6 - Nov 11
found 1 day ago
Roundtrip non-stop flight included
St. Louis (STL) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
I had a great stay at Megapolis. The breakfast was great and the hotel was always clean and fragrant. I would rebook this hotel on a return trip to Panama.
Reviewed on Sep 29, 2026
Riande Aeropuerto Hotel & Casino
Tocumen Airport
$1,014
per person
Nov 6 - Nov 11
found 1 day ago
Roundtrip non-stop flight included
St. Louis (STL) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.
Hotel Riu Plaza Panama
Bella Vista
$984
per person
Nov 6 - Nov 11
found 1 day ago
Roundtrip non-stop flight included
St. Louis (STL) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
The room looking at the city. Breakfast was excellent.
Reviewed on Sep 29, 2026
Hyatt Regency Panama City
Bella Vista
$1,071
per person
Nov 6 - Nov 11
found 1 day ago
Roundtrip non-stop flight included
St. Louis (STL) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Gracias
Reviewed on Sep 29, 2026
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See all available trips from Columbus to Eastern Panama
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Ordovician Beach Resort
Isla Grande Isla Grande Colon
Book a stay at this luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park ...
Ranchos de Chalia
Portobelo via Puerto Lindo, Unit 3 Puerto Lindo Colón
Stay at this hotel in Puerto Lindo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are located ...
Private Ocean-Front Cabin with private bathroom on San Blas Island
Diablo Island Narganá Guna Yala
Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime ...
san blas luxury tour
guna yala Nusatupo Guna Yala
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, free WiFi, and a private beach.
Discovery Gunayar
Archipiélago de San Blas Narganá Guna Yala
Stay at this lodge in Narganá. Enjoy free breakfast, an airport shuttle (surcharge), and housekeeping. Popular attractions Isla Chichime and Isla Diablo are ...
Ciel y Miel
Caillle Principale Cacique Provincia de Colón
Book a stay at this beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park ...
Cocoloco - Catamaran Lagoon 52F SAN BLAS
El Porvenir Narganá Guna Yala
Stay at this cruise ship in San Blas Islands. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Porvenir Museum and Isla Chichime ...
HOTEL ISLA GRANDE
Final de paseo La Punta Isla Grande, 01 Isla Grande Colón Province
Stay at this hotel in Isla Grande. Enjoy free breakfast, onsite spa services, and daily housekeeping. Popular attractions Isla Mamey and Portobelo National Park ...
Konsenda San Blas
Llano Cartí Km 11 El Llano Panamá Province
Stay at this hotel in El Llano. Enjoy free breakfast, free parking, and a garden.
Private Bedroom on Paradise San Blas Island
Isla Yansailadup Narganá Guna Yala
Stay at this guesthouse in Narganá. Enjoy free breakfast, an airport shuttle (surcharge), and a picnic area. Popular attractions Isla Diablo and Museum of the ...
San Blas Tour Aridub
Urgandi, Guna Yala, Panamá Narganá Guna Yala
Book a stay at this beach cabin in Narganá. Enjoy beach cabanas (surcharge), a beach shuttle (surcharge), and daily housekeeping.
San Blas Private Beach Cabin
Nusatupo Narganá Guna Yala
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
Private Over-Water Cabins on San Blas Island
C5W9 4M Nusatupo Narganá
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
San Blas Private Oceanfront Cabin
C5W9 4M Nusatupo Narganá Guna Yala
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge).
Private wood Cabins on San Blas island - private bathroom
Wailidup Island Narganá Guna Yala
Stay at this hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and a marina. Popular attractions Isla Chichime and Isla Diablo are located ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.
Thu, Oct 29 - Fri, Oct 30
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$250
Roundtrip
found 3 days ago
Thu, Oct 29 - Fri, Oct 30
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$315
Roundtrip
found 3 days ago
Fri, Oct 30 - Mon, Nov 23
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$450
Roundtrip
found 1 day ago
Fri, Oct 23 - Mon, Nov 23
MIA
Miami Intl.
PTY
Tocumen Intl.
$535
Roundtrip
found 1 day ago
Tue, Oct 27 - Wed, Oct 28
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$560
Roundtrip
found 4 hours ago
Best points of interest in Eastern Panama
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All accommodation types in Eastern Panama
More Types of Hotels
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