Eastern Panama Vacation Packages for 2025

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Eastern Panama Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 out of 5
Amador
per person
Sep 25 - Sep 29
found 7 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Panama City (PTY)
Stay at this 3.5-star hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
per person
Sep 25 - Sep 29
found 7 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Bella Vista
per person
Sep 25 - Sep 29
found 7 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
Bella Vista
per person
Sep 25 - Sep 29
found 7 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Panama City (PTY)
Stay at this 5-star luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Hotel Plaza Herrera

Hotel Plaza Herrera

3 out of 5
Casco Viejo
per person
Sep 25 - Sep 29
found 7 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Panama City (PTY)
Stay at this 3-star hotel in Panama City. Enjoy free breakfast, free WiFi, and valet parking (surcharge). Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Sheraton Grand Panama

Sheraton Grand Panama

4 out of 5
San Francisco
per person
Sep 25 - Sep 29
found 7 hours ago
Roundtrip non-stop flight included
Raleigh (RDU) to Panama City (PTY)
Stay at this 4-star spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Multiplaza Pacific Mall are located nearby.

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Top Hotel Deals

Private Over the Water Cabin on San Blas Island

Private Over the Water Cabin on San Blas Island

2 out of 5
9.542876, -78.899058, Narganá, San Blas
93 km from city center
Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Chichime ...
Ranchos de Chalia

Ranchos de Chalia

3 out of 5
Portobelo via Puerto Lindo, Unit 3, Puerto Lindo, Colón
161.23 km from city center
Stay at this 3-star hotel in Puerto Lindo. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National Park are ...
Ordovician Beach Resort

Ordovician Beach Resort

4.5 out of 5
Isla Grande, Isla Grande, Colon
160.42 km from city center
Stay at this 4.5-star luxury resort in Isla Grande. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Isla Mamey and Portobelo National ...
San Blas Paradise Private Cabins on Shipwreck Island - meals included

San Blas Paradise Private Cabins on Shipwreck Island - meals included

2 out of 5
Perro Island, Narganá, Guna Yala
92.17 km from city center
Book a stay at this beach hotel in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo ...
Private Ocean-Front Cabin with private bathroom on San Blas Island

Private Ocean-Front Cabin with private bathroom on San Blas Island

2 out of 5
Diablo Island, Narganá, Guna Yala
92.59 km from city center
Stay at this hotel in San Blas Islands. Enjoy free breakfast, an airport shuttle (surcharge), and a garden. Popular attractions Isla Diablo and Isla Chichime ...
San Blas Tour Aridub

San Blas Tour Aridub

2 out of 5
Urgandi, Guna Yala, Panamá, Narganá, Guna Yala
80.42 km from city center
Book a stay at this beach cabin in Narganá. Enjoy beach cabanas (surcharge), a beach shuttle (surcharge), and daily housekeeping.
Private bedroom on paradise San Blas Island - Meals Included

Private bedroom on paradise San Blas Island - Meals Included

2.5 out of 5
Isla Yansailadup, Narganá, Guna Yala
91.86 km from city center
Stay at this guesthouse in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Diablo and Museum of the ...
Discovery Gunayar

Discovery Gunayar

2 out of 5
Archipiélago de San Blas, Narganá, Guna Yala
86.38 km from city center
Book a stay at this beach lodge in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Isla Chichime and Isla ...
Ciel y Miel

Ciel y Miel

3 out of 5
Caillle Principale, Cacique, Provincia de Colón
164.99 km from city center
Stay at this 3-star beach hotel in Cacique. Enjoy free breakfast, free WiFi, and free valet parking. Popular attractions Isla Mamey and Portobelo National Park ...
Cabins in Asserya Island - San Blas paradise - meals included

Cabins in Asserya Island - San Blas paradise - meals included

2 out of 5
Aroma Island (Isla Anzuelo), Narganá, Guna Yala
91.98 km from city center
Stay at this hotel in San Blas Islands. Enjoy free breakfast, a marina, and an airport shuttle (surcharge). Popular attractions Museum and Isla Chichime are ...
Private Over-Water Cabins on San Blas Island

Private Over-Water Cabins on San Blas Island

2.5 out of 5
C5W9 4M Nusatupo, Narganá
88.56 km from city center
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
Cocoloco - Catamaran Lagoon 52F SAN BLAS

Cocoloco - Catamaran Lagoon 52F SAN BLAS

3 out of 5
El Porvenir, Narganá, Guna Yala
98.19 km from city center
Stay at this 3-star property in San Blas Islands. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Porvenir Museum and Isla Chichime ...
Konsenda San Blas

Konsenda San Blas

2 out of 5
Llano Cartí Km 11, El Llano, Panamá Province
86.7 km from city center
Stay at this hotel in El Llano. Enjoy free breakfast, free parking, and a garden.
Paradise Over the Water Cabins in San Blas

Paradise Over the Water Cabins in San Blas

2.5 out of 5
G4V2 48, Narganá, Guna Yala
98.35 km from city center
Book a stay at this beach cabin in San Blas Islands. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Porvenir Museum ...
San Blas Private Over-the-Water Cabin

San Blas Private Over-the-Water Cabin

2.5 out of 5
Nusatupo, Narganá, Guna Yala
82.6 km from city center
Book a stay at this beach cabin in Narganá. Enjoy free breakfast, a beach locale, and an airport shuttle (surcharge). Popular attractions Museum of the Kuna ...
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See all available properties in Eastern Panama
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Sep 17 - Thu, Sep 18
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$209 Roundtrip, found 4 days ago
$209
Roundtrip
found 4 days ago
Select Copa flight, departing Wed, Sep 17 from Juan Santamaría Intl. to Tocumen Intl., returning Thu, Sep 18, priced at $209 found 4 days ago
avianca
Wed, Sep 17 - Thu, Sep 18
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$230 Roundtrip, found 4 days ago
$230
Roundtrip
found 4 days ago
Select avianca flight, departing Wed, Sep 17 from Juan Santamaría Intl. to Tocumen Intl., returning Thu, Sep 18, priced at $230 found 4 days ago
Aeromexico
Thu, Aug 21 - Mon, Sep 22
MEX
Mexico City Intl.
PTY
Tocumen Intl.
$355 Roundtrip, found 4 days ago
$355
Roundtrip
found 4 days ago
Select Aeromexico flight, departing Thu, Aug 21 from Mexico City Intl. to Tocumen Intl., returning Mon, Sep 22, priced at $355 found 4 days ago
Delta
Fri, Jan 23 - Sat, Jan 24
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$545 Roundtrip, found 6 days ago
$545
Roundtrip
found 6 days ago
Select Delta flight, departing Fri, Jan 23 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Sat, Jan 24, priced at $545 found 6 days ago
American Airlines
Fri, Jan 23 - Sat, Jan 24
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$559 Roundtrip, found 6 days ago
$559
Roundtrip
found 6 days ago
Select American Airlines flight, departing Fri, Jan 23 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Sat, Jan 24, priced at $559 found 6 days ago