2025 5 Star Hotels in Otay Mesa

Choose two or more items and save on your trip:

Featured Otay Mesa 5 Star Hotels

Pendry San Diego

Pendry San Diego

5 out of 5
550 J Street San Diego CA
Fully refundableReserve now, pay when you stay
Pendry San Diego
The US Grant, a Luxury Collection Hotel, San Diego

The US Grant, a Luxury Collection Hotel, San Diego

5 out of 5
326 Broadway San Diego CA
Fully refundableReserve now, pay when you stay
The US Grant, a Luxury Collection Hotel, San Diego
Shore House at The Del, LXR Hotels & Resorts

Shore House at The Del, LXR Hotels & Resorts

5 out of 5
1500 Orange Avenue Coronado CA
Shore House at The Del, LXR Hotels & Resorts
Beach Village at The Del, LXR Hotels & Resorts

Beach Village at The Del, LXR Hotels & Resorts

5 out of 5
1500 Orange Avenue Coronado CA
Beach Village at The Del, LXR Hotels & Resorts
The Bower Coronado

The Bower Coronado

5 out of 5
1417 Orange Ave Coronado CA
Fully refundableReserve now, pay when you stay
The Bower Coronado
See all 4,860 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.