2025 4 Star Hotels in Seneca

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Featured Seneca 4 Star Hotels

The Delavan Hotel & Spa

The Delavan Hotel & Spa

4 out of 5
6461 Transit Road Bowmansville NY
Fully refundableReserve now, pay when you stay
The Delavan Hotel & Spa
The Mansion On Delaware Ave

The Mansion On Delaware Ave

4 out of 5
414 Delaware Ave Buffalo NY
The Mansion On Delaware Ave
DoubleTree by Hilton Hotel Buffalo - Amherst

DoubleTree by Hilton Hotel Buffalo - Amherst

4 out of 5
10 Flint Rd Buffalo NY
DoubleTree by Hilton Hotel Buffalo - Amherst
The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

4 out of 5
5195 Main Street Buffalo NY
The Mosey Buffalo Williamsville, Tapestry Collection by Hilton
Reikart House, Buffalo, a Tribute Portfolio Hotel

Reikart House, Buffalo, a Tribute Portfolio Hotel

4 out of 5
5000 Main Street Buffalo NY
Fully refundableReserve now, pay when you stay
Reikart House, Buffalo, a Tribute Portfolio Hotel
The Westin Buffalo

The Westin Buffalo

4 out of 5
250 Delaware Ave Buffalo NY
Fully refundableReserve now, pay when you stay
The Westin Buffalo
Buffalo Harmony House

Buffalo Harmony House

4.5 out of 5
70 Wadsworth Street Buffalo NY
Buffalo Harmony House
Lofts on Pearl Trademark Collection by Wyndham

Lofts on Pearl Trademark Collection by Wyndham

4 out of 5
92 Pearl Street Buffalo NY
Lofts on Pearl Trademark Collection by Wyndham
See all 855 properties in Seneca
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.