Clayton 4 Star Hotels In 2025

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Featured Clayton 4 Star Hotels

Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Hyatt Regency St. Louis at The Arch
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

4 out of 5
9801 Natural Bridge Road, St. Louis, MO
Renaissance St. Louis Airport Hotel
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
River City Casino & Hotel
Marriott St. Louis Grand

Marriott St. Louis Grand

4 out of 5
800 Washington Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
Marriott St. Louis Grand
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street, St. Louis, MO
Fully refundableReserve now, pay when you stay
21C Museum Hotel St Louis
St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton

4 out of 5
1820 Market Street, St. Louis, MO
St. Louis Union Station Hotel, Curio Collection by Hilton
Live by Loews - St.Louis

Live by Loews - St.Louis

4 out of 5
799 Clark ave, St. Louis, MO
Live by Loews - St.Louis
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

4 out of 5
421 N 8th St, St. Louis, MO
Fully refundableReserve now, pay when you stay
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
The Westin St. Louis

The Westin St. Louis

4.5 out of 5
811 Spruce St, St. Louis, MO
The Westin St. Louis
See all 1,764 properties in Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.