2026 4 Star Hotels in Downtown Santiago

Choose two or more items and save on your trip:

Featured Downtown Santiago 4 Star Hotels

Almacruz Hotel y Centro de Convenciones

Almacruz Hotel y Centro de Convenciones

4 out of 5
San Antonio 65 Santiago Region Metropolitana
Fully refundableReserve now, pay when you stay
Almacruz Hotel y Centro de Convenciones
Le Méridien Santiago

Le Méridien Santiago

4 out of 5
Av. Libertador Bernardo O'Higgins 136 Santiago Region Metropolitana
Fully refundableReserve now, pay when you stay
Le Méridien Santiago
Hotel Plaza San Francisco

Hotel Plaza San Francisco

4 out of 5
Alameda 816 Santiago Region Metropolitana
Fully refundableReserve now, pay when you stay
Hotel Plaza San Francisco
Luciano K Hotel

Luciano K Hotel

4.5 out of 5
Merced, 84 Santiago Región Metropolitana
Fully refundableReserve now, pay when you stay
Luciano K Hotel
Hotel Cumbres Lastarria

Hotel Cumbres Lastarria

4 out of 5
Jose Victorino Lastarria 299 Santiago Region Metropolitana
Fully refundableReserve now, pay when you stay
Hotel Cumbres Lastarria
Hotel Magnolia

Hotel Magnolia

4 out of 5
Calle Huérfanos 539 Santiago Región Metropolitana
Fully refundableReserve now, pay when you stay
Hotel Magnolia
Hotel Casa Zañartu

Hotel Casa Zañartu

4 out of 5
Avenida Compañia de Jesus 1520 Santiago Santiago
Fully refundable
Hotel Casa Zañartu
Casa Bueras Boutique Hotel

Casa Bueras Boutique Hotel

4.5 out of 5
Coronel Santiago Bueras 188 Santiago Region Metropolitana
Fully refundableReserve now, pay when you stay
Casa Bueras Boutique Hotel
Hotel Gran Palace

Hotel Gran Palace

4 out of 5
Huerfanos 1178 Santiago
Fully refundableReserve now, pay when you stay
Hotel Gran Palace
See all 986 properties in Downtown Santiago
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.