
South Central Houston Vacation Packages for 2025
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Top Hotel Deals

Hilton Houston Plaza/Medical Center
6633 Travis St, Houston, TX
4.38 km from South Central Houston
Stay at this 4.5-star luxury hotel in Houston. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the helpful staff and the clean rooms in ...

Hotel Zaza Houston Museum District
5701 Main Street, Houston, TX
2.72 km from South Central Houston
Stay at this 4.5-star luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff and the property ...

InterContinental Houston by IHG
6750 Main St, Houston, TX
4.65 km from South Central Houston
Stay at this 4-star business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...

DoubleTree by Hilton Houston Medical Center Hotel & Suites
6800 Main Street, Houston, TX
4.68 km from South Central Houston
Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ...

The Westin Houston Medical Center/Museum District
1709 DRYDEN ROAD, Houston, TX
4.26 km from South Central Houston
Stay at this 4-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ...

Extended Stay America Suites Houston Med Ctr Braeswood Bl
1301 Braeswood Blvd, Houston, TX
4.72 km from South Central Houston
Book a stay at this business-friendly hotel in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...

Houston Marriott Medical Center/Museum District
6580 Fannin Street, Houston, TX
4.2 km from South Central Houston
Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful staff ...

Americas Best Value Inn Medical Center Downtown
2419 Riverside Dr, Houston, TX
1.89 km from South Central Houston
Stay at this motel in Houston. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...

Hilton University of Houston
4450 University Drive, Houston, TX
2.29 km from South Central Houston
Stay at this 3.5-star business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a fitness center. Our guests praise the helpful staff ...

Rodeway Inn & Suites Houston near Medical Center
6712 Morningside Dr, Houston, TX
5.54 km from South Central Houston
Stay at this motel in Houston. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions NRG Stadium and Toyota Center are located ...

Wanderstay Houston Hostel
4018 Chartres St, Houston, TX
1.05 km from South Central Houston
Stay at this hostel in Houston. Enjoy free WiFi, parking (surcharge), and daily housekeeping. Popular attractions Toyota Center and Daikin Park are located ...

La Maison in Midtown an urban B&B
2800 Brazos, Houston, TX
2.63 km from South Central Houston
Stay at this 3.5-star business-friendly B&B in Houston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

Modern Cozy Home with King Bed
2307 Briley St, Houston, TX
1.21 km from South Central Houston
Stay at this 3.5-star vacation home in Houston. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Toyota Center and Daikin Park are located ...
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View all propertiesLowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Thu, Jun 5 - Sun, Jun 8
ATL
Hartsfield-Jackson Atlanta Intl.
IAH
George Bush Intercontinental
$87 Roundtrip, found 5 days ago
$87
Roundtrip
found 5 days ago

Thu, Jul 10 - Thu, Jul 17
LAX
Los Angeles Intl.
IAH
George Bush Intercontinental
$126 Roundtrip, found 11 hours ago
$126
Roundtrip
found 11 hours ago

Tue, Jul 8 - Tue, Jul 15
PHL
Philadelphia Intl.
IAH
George Bush Intercontinental
$140 Roundtrip, found 2 days ago
$140
Roundtrip
found 2 days ago

Sat, Jun 28 - Sun, Jun 29
DTW
Detroit Metropolitan Wayne County
IAH
George Bush Intercontinental
$147 Roundtrip, found 3 days ago
$147
Roundtrip
found 3 days ago
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