
Santo Spirito Vacation Packages for 2026
Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*
Santo Spirito Flight + Hotel packages
Price found within the past 48 hours. Click for updated prices.

Art Atelier
Historic Centre of Florence
Price was $855, price is now $618 per person
$618
per person
Jan 25 - Jan 29
found 15 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, room service, and a 24-hour front desk. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Cathedral of Santa Maria del Fiore and Piazza del Duomo are located nearby.

The Moon Boutique Hotel & Spa
Historic Centre of Florence
Price was $1,265, price is now $877 per person
$877
per person
Jan 25 - Jan 29
found 15 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
Book a stay at this spa hotel in Florence. Enjoy free WiFi, a full-service spa, and room service. Our guests praise the helpful staff in our reviews. Popular attractions Cathedral of Santa Maria del Fiore and Ponte Vecchio are located nearby.

Bernini Palace
Historic Centre of Florence
Price was $1,367, price is now $1,056 per person
$1,056
per person
Jan 25 - Jan 29
found 15 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
Book a stay at this luxury hotel in Florence. Enjoy free breakfast, free WiFi, and a rooftop terrace. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Palazzo Vecchio and Piazza della Signoria are located nearby.

Art Hotel Villa Agape
Oltrarno
Price was $786, price is now $627 per person
$627
per person
Jan 25 - Jan 29
found 15 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
Stay at this hotel in Florence. Enjoy free WiFi, free parking, and a rooftop terrace. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Piazzale Michelangelo and Pitti Palace are located nearby.

Palazzo Castri 1874 Spa & Garden
Historic Centre of Florence
Price was $1,012, price is now $814 per person
$814
per person
Jan 25 - Jan 29
found 15 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
Book a stay at this spa hotel in Florence. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions Cathedral of Santa Maria del Fiore and Piazza del Duomo are located nearby.

Grand Hotel Cavour
Historic Centre of Florence
Price was $917, price is now $745 per person
$745
per person
Jan 25 - Jan 29
found 15 hours ago
Roundtrip non-stop flight included
Newark Liberty Intl. Airport (EWR) to Florence (FLR)
Book a stay at this family-friendly hotel in Florence. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Piazza della Signoria and Palazzo Vecchio are located nearby.
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Hotel Horto Convento
Viale Ariosto, 13 Florence FI
0.42 km from Santo Spirito
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...

Palazzo Mannaioni Suites
Via Maffia 9 - 17r Florence FI
0.93 km from Santo Spirito
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and satellite TV channels. Our guests praise the helpful staff in our reviews. Popular ...

La Torre Del Cestello
Via Borgo San Frediano, 8 Florence FI
0.86 km from Santo Spirito
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Pitti Palace and Ponte Vecchio are ...

UNA Hotels Vittoria Firenze
Via Pisana 59 Florence FI
0.49 km from Santo Spirito
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...

Oltrarno Splendid
Via dei Serragli 7 Florence FI
0.89 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free breakfast, free WiFi, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...

Casa Santo Nome di Gesù
Piazza del Carmine, 21 Florence FI
0.68 km from Santo Spirito
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...

La Fonderia Firenze
Via della Fonderia 65/A Florence FI
0.65 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free breakfast, free WiFi, and a garden. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions ...

B&B Mia Palace
Via della Fonderia 8 Florence FI
0.66 km from Santo Spirito
Stay at this affittacamere in Florence. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Pitti Palace and Ponte Vecchio are ...

Foresteria Valdese di Firenze - Casa per Ferie
Via dei Serragli 49 Florence FI
0.78 km from Santo Spirito
Stay at this property in Florence. Enjoy free WiFi, 2 meeting rooms, and satellite TV channels. Our guests praise the helpful staff and the clean rooms in our ...

Ottantotto Firenze
Via dei Serragli 88 Florence FI
0.75 km from Santo Spirito
Stay at this guesthouse in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular attractions ...

Palazzo Guicciardini
via Santo Spirito 14 Florence FI
1.06 km from Santo Spirito
Book a stay at this luxury guesthouse in Florence. Enjoy free WiFi, in-room massages, and a 24-hour front desk. Popular attractions Pitti Palace and Ponte Vecchio ...

1900 Artevita
Viale Raffaello Sanzio 2 Florence FI
0.49 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free WiFi, breakfast (surcharge), and housekeeping. Popular attractions Pitti Palace and Ponte Vecchio are located ...

Drom Florence Rooms & Apartments
Via dei Serragli 137 Florence FI
0.76 km from Santo Spirito
Stay at this guesthouse in Florence. Enjoy free WiFi, a garden, and premium bedding. Our guests praise the property condition in our reviews. Popular attractions ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Flight Deals
These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Tue, Apr 21 - Tue, Apr 28
JFK
John F. Kennedy Intl.
FLR
Peretola
$434 Roundtrip, found 2 days ago
$434
Roundtrip
found 2 days ago

Sun, Apr 26 - Wed, Apr 29
JFK
John F. Kennedy Intl.
FLR
Peretola
$477 Roundtrip, found 2 days ago
$477
Roundtrip
found 2 days ago

Tue, Apr 21 - Mon, Apr 27
JFK
John F. Kennedy Intl.
FLR
Peretola
$479 Roundtrip, found 2 days ago
$479
Roundtrip
found 2 days ago

Sun, Apr 26 - Sat, May 2
JFK
John F. Kennedy Intl.
FLR
Peretola
$586 Roundtrip, found 2 days ago
$586
Roundtrip
found 2 days ago

Mon, Apr 27 - Wed, Apr 29
JFK
John F. Kennedy Intl.
FLR
Peretola
$666 Roundtrip, found 2 days ago
$666
Roundtrip
found 2 days ago

