Santo Spirito Vacation Packages for 2026

Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*

Choose two or more items and save on your trip:

Top Hotel Deals

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
0.42 km from Santo Spirito
Stay at this hotel in Florence. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful staff in our reviews. Popular ...
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
0.86 km from Santo Spirito
Stay at this residence in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Popular attractions Ponte Vecchio and Uffizi Gallery ...
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
0.49 km from Santo Spirito
Book a stay at this boutique hotel in Florence. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie

Via dei Serragli 49 Florence FI
0.78 km from Santo Spirito
Stay at this guesthouse in Florence. Enjoy free WiFi, 2 meeting rooms, and satellite TV channels. Our guests praise the helpful staff and the clean rooms in ...
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
0.93 km from Santo Spirito
Stay at this residence in Florence. Enjoy free WiFi, concierge services, and premium bedding. Our guests praise the helpful staff in our reviews. Popular attractions ...
Torre di Bellosguardo

Torre di Bellosguardo

4 out of 5
Via Roti Michelozzi 2 Florence FI
0.46 km from Santo Spirito
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, free parking, and an outdoor pool. Popular attractions Ponte Vecchio and Uffizi Gallery ...
Hostel Santa Monaca

Hostel Santa Monaca

Via Santa Monaca 6 Florence FI
0.78 km from Santo Spirito
Stay at this hostel in Florence. Enjoy free WiFi, daily housekeeping, and dry cleaning or laundry services. Popular attractions Ponte Vecchio and Uffizi Gallery ...
Casa Santo Nome di Gesù

Casa Santo Nome di Gesù

Piazza del Carmine, 21 Florence FI
0.68 km from Santo Spirito
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions ...
Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8

Via Borgo San Frediano n. 8 Florence FI
0.9 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free WiFi, valet parking (surcharge), and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular ...
Hotel Palazzo Guadagni

Hotel Palazzo Guadagni

3 out of 5
Piazza Santo Spirito 9 Florence FI
0.95 km from Santo Spirito
Book a stay at this business-friendly hotel in Florence. Enjoy free WiFi, a rooftop terrace, and breakfast (surcharge). Popular attractions Ponte Vecchio and ...
Oltrarno Splendid

Oltrarno Splendid

Via dei Serragli 7 Florence FI
0.89 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free breakfast, free WiFi, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
Santo Spirito Venti

Santo Spirito Venti

Via Santo Spirito 20 Florence FI
1.02 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free WiFi, breakfast (surcharge), and premium bedding. Popular attractions Ponte Vecchio and Uffizi Gallery are located ...
Palazzo Oliveto

Palazzo Oliveto

Via Monte Oliveto Florence FI
0.3 km from Santo Spirito
Stay at this guesthouse in Florence. Enjoy free breakfast, free WiFi, and a garden. Popular attractions Ponte Vecchio and Uffizi Gallery are located nearby.
La Fonderia Firenze

La Fonderia Firenze

Via della Fonderia 65/A Florence FI
0.65 km from Santo Spirito
Stay at this B&B in Florence. Enjoy free breakfast, free WiFi, and a garden. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions ...
Ostello Tasso

Ostello Tasso

VIA VILLANI 15 , PIAZZA TASSO Florence FI
0.33 km from Santo Spirito
Stay at this hostel in Florence. Enjoy free WiFi, daily housekeeping, and rainfall showerheads. Popular attractions Ponte Vecchio and Uffizi Gallery are located ...
Don't see what you're looking for?
See all available properties in Santo Spirito
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

ITA Airways
Mon, Aug 10 - Thu, Aug 27
JFK
John F. Kennedy Intl.
FLR
Peretola
$644 Roundtrip, found 5 days ago
$644
Roundtrip
found 5 days ago
Select ITA Airways flight, departing Mon, Aug 10 from John F. Kennedy Intl. to Peretola, returning Thu, Aug 27, priced at $644 found 5 days ago
Swiss International Air Lines
Mon, Aug 10 - Thu, Aug 27
JFK
John F. Kennedy Intl.
FLR
Peretola
$651 Roundtrip, found 5 days ago
$651
Roundtrip
found 5 days ago
Select Swiss International Air Lines flight, departing Mon, Aug 10 from John F. Kennedy Intl. to Peretola, returning Thu, Aug 27, priced at $651 found 5 days ago
United
Mon, Aug 10 - Thu, Aug 27
JFK
John F. Kennedy Intl.
FLR
Peretola
$658 Roundtrip, found 5 days ago
$658
Roundtrip
found 5 days ago
Select United flight, departing Mon, Aug 10 from John F. Kennedy Intl. to Peretola, returning Thu, Aug 27, priced at $658 found 5 days ago
Delta
Mon, Aug 10 - Thu, Aug 27
JFK
John F. Kennedy Intl.
FLR
Peretola
$660 Roundtrip, found 5 days ago
$660
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Aug 10 from John F. Kennedy Intl. to Peretola, returning Thu, Aug 27, priced at $660 found 5 days ago
Brussels Airlines
Mon, Aug 10 - Thu, Aug 27
JFK
John F. Kennedy Intl.
FLR
Peretola
$670 Roundtrip, found 5 days ago
$670
Roundtrip
found 5 days ago
Select Brussels Airlines flight, departing Mon, Aug 10 from John F. Kennedy Intl. to Peretola, returning Thu, Aug 27, priced at $670 found 5 days ago