Santa Clara Vacations

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Santa Clara Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Save 100% on your flight
Price was $1,186, price is now $708 per person
$708
per person
Sep 6 - Sep 12
found 23 hours ago
Roundtrip non-stop flight included
Tampa (TPA) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was $1,920, price is now $828 per person
$828
per person
Sep 6 - Sep 12
found 1 day ago
Roundtrip non-stop flight included
Tampa (TPA) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was $2,319, price is now $1,102 per person
$1,102
per person
Sep 6 - Sep 12
found 1 day ago
Roundtrip non-stop flight included
Tampa (TPA) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Save 100% on your flight
Price was $1,191, price is now $750 per person
$750
per person
Sep 6 - Sep 12
found 23 hours ago
Roundtrip non-stop flight included
Tampa (TPA) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Breakfast

Reviewed on Jul 26, 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was $1,183, price is now $821 per person
$821
per person
Sep 6 - Sep 12
found 23 hours ago
Roundtrip non-stop flight included
Tampa (TPA) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Decent, the decor is nice, but the rooms really busy smelling and had congestion the whole time. The pool is small and that area isn't well maintained or served.

Reviewed on Jul 26, 2026

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
Price was $1,114, price is now $797 per person
$797
per person
Sep 6 - Sep 12
found 1 day ago
Roundtrip non-stop flight included
Tampa (TPA) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

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Top Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
25.49 km from city center
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and 3 restaurants. Our guests praise the breakfast and the pool in our reviews. ...
Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
Avenida Balboa Panama City
25.96 km from city center
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in ...
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz Veracruz Panama
23.45 km from city center
Book a stay at this beach property in Veracruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the pool and the helpful staff in our reviews. ...
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
25.02 km from city center
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and room service. Our guests praise the helpful staff and the clean ...
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
25.19 km from city center
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the helpful staff in our reviews. ...
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

4 out of 5
Calle Augusto Samuel Boyd y Calle Eusebi Panama City
24.61 km from city center
Book a stay at this spa B&B in Panama City. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Albrook Shopping Mall and Via Espana are located ...
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Plaza de la Independencia Casco Viejo Panama City Panama
25.01 km from city center
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall

4 out of 5
Via Israel Multiplaza Pacific Mall Panama City Panama
26.37 km from city center
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
24.85 km from city center
Book a stay at this spa hotel in Panama City. Enjoy free breakfast, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. ...
Courtyard by Marriott Panama Metromall

Courtyard by Marriott Panama Metromall

4 out of 5
Avenida Domingo Diaz via Tocumen San Miguelito Panama
32.91 km from city center
Book a stay at this business-friendly hotel in San Miguelito. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in ...
The Executive Hotel

The Executive Hotel

3.5 out of 5
Calle 52 Panama City Panama
25.04 km from city center
Book a stay at this business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in ...
Aloft by Marriott Panama

Aloft by Marriott Panama

3.5 out of 5
Via Israel & Calle 76 Panama City Panama
27.38 km from city center
Book a stay at this business-friendly hotel in Panama City. Enjoy free WiFi, free parking, and a nightclub. Our guests praise the helpful staff in our reviews. ...
Radisson Hotel Panama Canal

Radisson Hotel Panama Canal

4.5 out of 5
Amador Avenue & Van Hook Street Panama City Panama
23.38 km from city center
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and 2 outdoor pools. Our guests praise the helpful staff and the property condition ...
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
25.19 km from city center
Book a stay at this luxury hotel in Panama City. Enjoy 2 restaurants, 3 hot tubs, and 2 bars/lounges. Our guests praise the helpful staff in our reviews. Popular ...
JW Marriott Panama

JW Marriott Panama

5 out of 5
Calle Punta Colon, Punta Pacifica Panama City Panama
27.13 km from city center
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, 4 outdoor pools, and 3 restaurants. Our guests praise the helpful staff in our reviews. Popular ...
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See all available properties in Santa Clara
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Mon, Jan 25 - Tue, Jan 26
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$264 Roundtrip, found 1 day ago
$264
Roundtrip
found 1 day ago
Select Copa flight, departing Mon, Jan 25 from Juan Santamaría Intl. to Tocumen Intl., returning Tue, Jan 26, priced at $264 found 1 day ago
avianca
Mon, Jan 25 - Tue, Jan 26
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$290 Roundtrip, found 1 day ago
$290
Roundtrip
found 1 day ago
Select avianca flight, departing Mon, Jan 25 from Juan Santamaría Intl. to Tocumen Intl., returning Tue, Jan 26, priced at $290 found 1 day ago
American Airlines
Sun, Sep 6 - Sat, Sep 19
MIA
Miami Intl.
PTY
Tocumen Intl.
$416 Roundtrip, found 3 days ago
$416
Roundtrip
found 3 days ago
Select American Airlines flight, departing Sun, Sep 6 from Miami Intl. to Tocumen Intl., returning Sat, Sep 19, priced at $416 found 3 days ago
United
Mon, Oct 26 - Sun, Nov 1
MIA
Miami Intl.
PTY
Tocumen Intl.
$477 Roundtrip, found 3 days ago
$477
Roundtrip
found 3 days ago
Select United flight, departing Mon, Oct 26 from Miami Intl. to Tocumen Intl., returning Sun, Nov 1, priced at $477 found 3 days ago
Delta
Thu, Aug 27 - Tue, Sep 8
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$616 Roundtrip, found 9 hours ago
$616
Roundtrip
found 9 hours ago
Select Delta flight, departing Thu, Aug 27 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Tue, Sep 8, priced at $616 found 9 hours ago