Cheap 2026 Otay Mesa West Hotels
Photo by Leonardo De Leon
Choose from 6847 Otay Mesa West Hotel Deals
Sheraton San Diego Resort
1380 Harbor Island Dr San Diego CA
Free Cancellation
Reserve now, pay when you stay
21.38 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 outdoor pools, and 5 restaurants. Our guests praise the pool and the restaurant ...
Hard Rock Hotel San Diego
207 5th Ave San Diego CA
Free Cancellation
Reserve now, pay when you stay
17.51 km from Otay Mesa West
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
Courtyard by Marriott San Diego Downtown Little Italy
1646 Front St San Diego CA
Free Cancellation
Reserve now, pay when you stay
19.15 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue San Diego CA
Free Cancellation
Reserve now, pay when you stay
19.06 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...
The US Grant, a Luxury Collection Hotel, San Diego
326 Broadway San Diego CA
Free Cancellation
Reserve now, pay when you stay
18.38 km from Otay Mesa West
Book a stay at this luxury hotel in San Diego. Enjoy breakfast (surcharge), 24-hour room service, and a 24-hour fitness center. Our guests praise the helpful ...
Hilton San Diego Mission Valley
901 Camino Del Rio S San Diego CA
Free Cancellation
Reserve now, pay when you stay
22.79 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...
Manchester Grand Hyatt San Diego
1 Market Pl San Diego CA
Free Cancellation
Reserve now, pay when you stay
18.19 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the helpful staff ...
San Diego Mission Bay Resort
1775 E Mission Bay Dr San Diego CA
Free Cancellation
Reserve now, pay when you stay
26.81 km from Otay Mesa West
Book a stay at this beach hotel in San Diego. Enjoy free WiFi, a full-service spa, and 2 restaurants. Our guests praise the pool and the helpful staff in our ...
The Dana on Mission Bay
1710 W Mission Bay Dr San Diego CA
Free Cancellation
Reserve now, pay when you stay
27.13 km from Otay Mesa West
Stay at this hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular attractions ...
Pendry San Diego
550 J Street San Diego CA
Free Cancellation
Reserve now, pay when you stay
17.66 km from Otay Mesa West
Book a stay at this luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...
Best Western Seven Seas
411 Hotel Circle South San Diego CA
Free Cancellation
Reserve now, pay when you stay
22.89 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
Sentral Gaslamp Quarter
502 10th Avenue San Diego CA
Free Cancellation
Reserve now, pay when you stay
17.58 km from Otay Mesa West
Stay at this hotel in San Diego. Enjoy free WiFi, a rooftop terrace, and a 24-hour fitness center. Popular attractions Petco Park and Port of San Diego are located ...
Bay Club Hotel & Marina
2131 Shelter Island Dr San Diego CA
Free Cancellation
Reserve now, pay when you stay
22.12 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant in ...
Lafayette Hotel & Club
2223 El Cajon Blvd San Diego CA
Free Cancellation
Reserve now, pay when you stay
21.31 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 3 bars/lounges. Our guests praise the helpful staff in our reviews. ...
DoubleTree by Hilton Hotel San Diego - Mission Valley
7450 Hazard Center Dr San Diego CA
Free Cancellation
Reserve now, pay when you stay
23.53 km from Otay Mesa West
Book a stay at this business-friendly hotel in San Diego. Enjoy breakfast (surcharge), room service, and a 24-hour fitness center. Our guests praise the helpful ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa West, San Diego Hotel Guide
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