
Cheap 2025 Otay Mesa West Hotels
Photo by Leonardo De Leon
Choose from 6755 Otay Mesa West Hotel Deals

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
19.21 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...

Manchester Grand Hyatt San Diego
1 Market Pl, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
18.19 km from Otay Mesa West
Stay at this 4-star eco-certified hotel in San Diego. Enjoy free WiFi, 6 restaurants, and 3 bars/lounges. Our guests praise the pool and the bar in our reviews. ...

The DEXTRO Little Italy, BW Premier Collection
1617 1st Avenue, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
19.06 km from Otay Mesa West
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and a 24-hour fitness center. Our guests praise the helpful ...

Palihotel San Diego Gaslamp Quarter
830 Sixth Avenue, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
18.09 km from Otay Mesa West
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 bars/lounges, and breakfast (surcharge). Our guests praise the restaurant and the helpful staff in ...

Handlery Hotel
950 Hotel Cir N, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
23.14 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the bar in our ...

Hard Rock Hotel San Diego
207 5th Ave, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
17.51 km from Otay Mesa West
Stay at this 4-star hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our ...

Best Western Plus Marina Gateway Hotel
800 Bay Marina Dr, National City, CA
Free Cancellation
Reserve now, pay when you stay
10.5 km from Otay Mesa West
Stay at this 3.5-star eco-certified hotel in National City. Enjoy free WiFi, free parking, and a golf course. Our guests praise the pool and the restaurant in ...

Pendry San Diego
550 J Street, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
17.66 km from Otay Mesa West
Stay at this 5-star luxury hotel in San Diego. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms ...

Days Inn by Wyndham San Diego Hotel Circle
543 Hotel Circle S, San Diego, CA
22.93 km from Otay Mesa West
Stay at this 3-star business-friendly hotel in San Diego. Enjoy free WiFi, a fitness center, and parking (surcharge). Our guests praise the helpful staff and ...

Hilton San Diego Mission Valley
901 Camino Del Rio S, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
22.79 km from Otay Mesa West
Stay at this 4-star business-friendly hotel in San Diego. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff and the ...

Hotel del Coronado, Curio Collection by Hilton
1500 Orange Ave, Coronado, CA
Free Cancellation
Reserve now, pay when you stay
16.28 km from Otay Mesa West
Stay at this 4-star beach resort in Coronado. Enjoy free WiFi, 6 restaurants, and a private beach. Our guests praise the helpful staff and the property condition ...

Bay Club Hotel & Marina
2131 Shelter Island Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
22.11 km from Otay Mesa West
Stay at this 3.5-star business-friendly hotel in San Diego. Enjoy free WiFi, a marina, and a health club. Our guests praise the breakfast and the restaurant ...

The Dana on Mission Bay
1710 W Mission Bay Dr, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
27.07 km from Otay Mesa West
Stay at this 3.5-star hotel in San Diego. Enjoy 2 outdoor pools, a marina, and 2 hot tubs. Our guests praise the pool and the restaurant in our reviews. Popular ...

The Sofia Hotel
150 W Broadway, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
18.5 km from Otay Mesa West
Stay at this 3.5-star historic hotel in San Diego. Enjoy free WiFi, room service, and a 24-hour fitness center. Our guests praise the helpful staff and the clean ...

Legacy Resort Hotel & Spa
875 Hotel Circle South, San Diego, CA
Free Cancellation
Reserve now, pay when you stay
22.93 km from Otay Mesa West
Stay at this 4-star spa hotel in San Diego. Enjoy free WiFi, a full-service spa, and breakfast (surcharge). Our guests praise the pool and the restaurant in ...
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Otay Mesa West, San Diego Hotel Guide
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