Business Hotels in Orangeburg 2026
Photo by Corey Dargan
Featured Orangeburg Business Hotels
Baymont by Wyndham Orangeburg North
3583 Saint Matthews Rd Orangeburg SC
Hampton Inn Santee-I-95
9060 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
Spark by Hilton Orangeburg
731 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
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Hampton Inn & Suites Orangeburg
749 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
Econo Lodge
9112 Old 6 Highway Santee SC
Southern Lodge
3616 Saint Matthews Rd Orangeburg SC
Super 8 by Wyndham, Orangeburg
3608 Saint Matthews Rd Orangeburg SC
Best Western Plus Santee Inn
I 95 Exit 98 Santee SC
Fully refundableReserve now, pay when you stay
Comfort Inn & Suites Orangeburg
746 Citadel Rd Orangeburg SC
Comfort Inn & Suites Santee
221 Britain St Santee SC
Days Inn by Wyndham Orangeburg
3691 Saint Matthews Rd Orangeburg SC
Fairfield Inn by Marriott Orangeburg
663 Citadel Road Orangeburg SC
Fully refundableReserve now, pay when you stay
Holiday Inn Express & Suites Orangeburg by IHG
118 Sleep Inn Road Orangeburg SC
Fully refundable
Holiday Inn Santee by IHG
139 Bradford Blvd Santee SC
Fully refundable
Baymont by Wyndham Santee
249 Britain Street Santee SC
Travelodge by Wyndham Santee
9117 Old Number Six Hwy Santee SC
American INN of Orangeburg
610 John C Calhoun Dr Orangeburg SC
Super 8 by Wyndham Santee
9125 Old Highway 6 Santee SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.