Nuevo Santiago Vacations

Build a Flight + Hotel Bundle & Save up to $536 On Your Vacation*

Choose two or more items and save on your trip:

Nuevo Santiago Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Sheraton Grand Panama

Sheraton Grand Panama

San Francisco
$862
per person
Oct 24 - Oct 28
found 20 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this spa resort in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Multiplaza Pacific Mall are located nearby.
Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
$1,113
per person
Oct 24 - Oct 28
found 20 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
$1,095
per person
Oct 24 - Oct 28
found 20 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.
everything was great, specially with the assistance that we have at the front desk with my flat tire

Reviewed on Aug 9, 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

Bella Vista
$911
per person
Oct 24 - Oct 28
found 21 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and 2 restaurants. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.
Great atmosphere. Staff was very helpful when asking for directions and information, some more than others. Everything was clean. I really liked this hotel and my stay.

Reviewed on Aug 4, 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

$895
per person
Oct 24 - Oct 28
found 20 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this family-friendly resort in Tocumen. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Metromall Panama and Los Pueblos Commercial Center are located nearby.
Buena alternativa para descansar y a pocos minutos del aeropuerto.

Reviewed on Aug 9, 2026

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz
$1,064
per person
Oct 24 - Oct 28
found 20 hours ago
Roundtrip non-stop flight included
Orlando (MCO) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular attractions Panama Viejo and Multiplaza Pacific Mall are located nearby.
We were told the van we hired to go to the airport was US$35. The driver charged my husband US$50 plus US$5 because just exciting to the way to the airport we had to come back the hotel because my granddaughter has left her wallet in the security case in her room. He was a very nice driver, but it was unethical from his part to charge more than we were adviced

Reviewed on Aug 9, 2026

Don't see what you're looking for?
See all available trips from Columbus to Nuevo Santiago
View all trips

Top Hotel Deals

Hotel Mykonos Panama

Hotel Mykonos Panama

Panamerican Highway Nuevo Santiago Veraguas
2.32 km from city center
Book a stay at this spa hotel in Nuevo Santiago. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Plaza Banconal and Omar Torrijos Herrera ...
Hotel Plaza Los Tucanes

Hotel Plaza Los Tucanes

Vía interamericana Nuevo Santiago Provincia de Veraguas
4.75 km from city center
Book a stay at this business-friendly hotel in Nuevo Santiago. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Plaza Banconal and Omar ...
Hotel Galería

Hotel Galería

Vía Interamericana Santiago, Km 232.88 Nuevo Santiago
4.48 km from city center
Book a stay at this business-friendly hotel in Nuevo Santiago. Enjoy free WiFi, free parking, and 2 outdoor pools. Popular attractions Plaza Banconal and Omar ...
Hotel Plaza

Hotel Plaza

Interamericana Nuevo Santiago Veraguas
3.14 km from city center
Book a stay at this family-friendly hotel in Nuevo Santiago. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Plaza Banconal and ...
Hotel Gran David

Hotel Gran David

Vía Interamericana Santiago Veraguas
4.7 km from city center
Stay at this hotel in Santiago. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Plaza ...
HOTEL VISTA LAGO

HOTEL VISTA LAGO

Rincón Largo La Pena Santiago de Veraguas
14.28 km from city center
Stay at this hotel in La Pena. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Parque Acuatico Italia Guadalupe Panama and Omar Torrijos ...
Hotel La Hacienda

Hotel La Hacienda

Via Interamericana Rodrigo Luque Veraguas
6.23 km from city center
Book a stay at this family-friendly hotel in Rodrigo Luque. Enjoy free WiFi, free parking, and a casino. Popular attractions Parque Acuatico Italia Guadalupe ...
HOTEL CORPORATIVO PLAZA COROTÚ

HOTEL CORPORATIVO PLAZA COROTÚ

Carr. Panamericana Santiago Provincia de Veraguas
4.12 km from city center
Stay at this hotel in Santiago. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Plaza Banconal and Omar Torrijos Herrera Stadium ...
HOTEL PLAZA COROTÚ

HOTEL PLAZA COROTÚ

Carr. Panamericana Santiago Provincia de Veraguas
4.12 km from city center
Stay at this hotel in Santiago. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Plaza Banconal and Omar Torrijos Herrera Stadium ...
Hostal Brisas Calobreñas

Hostal Brisas Calobreñas

Calobre Calobre Veraguas
25.87 km from city center
Stay at this hostal in Calobre. Enjoy free WiFi, free parking, and breakfast (surcharge).
Hostal Travelers

Hostal Travelers

Santiago de Veraguas Santiago Veraguas
5.94 km from city center
Stay at this hostal in Santiago. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Omar Torrijos Herrera Stadium and Plaza Banconal ...
Black Lion Inn

Black Lion Inn

Vía Interamericana La Mata Veraguas
4.68 km from city center
Stay at this hostal in La Mata. Enjoy free WiFi, free parking, and daily housekeeping. Popular attractions Los Pozos Termales and Plaza Banconal are located ...
Don't see what you're looking for?
See all available properties in Nuevo Santiago
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.