Greenville Vacations

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Greenville Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
Aloft by Marriott St Louis Central West End

Aloft by Marriott St Louis Central West End

Central West End
$351
per person
Dec 19 - Dec 23
found 23 hours ago
Roundtrip flight included
Chicago (CHI) to St. Louis (STL)
Stay at this hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and valet parking (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions St. Louis Zoo and St. Louis Union Station are located nearby.
Super helpful staff who made excellent suggestions for what to see and do!!

Reviewed on Oct 12, 2026

The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

Central West End
Save 100% on your flight
$490
per person
Dec 19 - Dec 23
found 23 hours ago
Roundtrip flight included
Chicago (CHI) to St. Louis (STL)
Book a stay at this luxury hotel in St. Louis. Enjoy free WiFi, an outdoor pool, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions St. Louis Zoo and St. Louis Union Station are located nearby.
Landing Furnished Apartments - Central West End

Landing Furnished Apartments - Central West End

Central West End
Save 100% on your flight
$443
per person
Dec 19 - Dec 23
found 23 hours ago
Roundtrip flight included
Chicago (CHI) to St. Louis (STL)
Book a stay at this business-friendly apartment in St. Louis. Enjoy free WiFi, an outdoor pool, and a 24-hour fitness center. Popular attractions St. Louis Union Station and Enterprise Center are located nearby.
The Knight Center at Washington University

The Knight Center at Washington University

$358
per person
Dec 19 - Dec 23
found 23 hours ago
Roundtrip flight included
Chicago (CHI) to St. Louis (STL)
Stay at this hotel in St. Louis. Enjoy free WiFi, breakfast (surcharge), and parking (surcharge). Our guests praise the helpful staff in our reviews. Popular attractions St. Louis Zoo and St. Louis Union Station are located nearby.
River City Casino & Hotel

River City Casino & Hotel

$374
per person
Dec 19 - Dec 23
found 23 hours ago
Roundtrip flight included
Chicago (CHI) to St. Louis (STL)
Book a stay at this business-friendly hotel in St. Louis. Enjoy free parking, 5 restaurants, and a casino. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions River City Casino and Jefferson Barracks Historic Park are located nearby.
Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch

Downtown St. Louis
$356
per person
Dec 19 - Dec 23
found 23 hours ago
Roundtrip flight included
Chicago (CHI) to St. Louis (STL)
Book a stay at this business-friendly hotel in St. Louis. Enjoy breakfast (surcharge), a fitness center, and valet parking (surcharge). Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Gateway Arch and Enterprise Center are located nearby.
Beautiful

Reviewed on Oct 12, 2026

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Top Hotel Deals

Comfort Inn & Suites Greenville I-70

Comfort Inn & Suites Greenville I-70

2265 S. State Route 127 Greenville IL
3.84 km from city center
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
SureStay Hotel by Best Western Greenville

SureStay Hotel by Best Western Greenville

1731 S State Route 127 Greenville IL
2.64 km from city center
Book a stay at this business-friendly hotel in Greenville. Enjoy free breakfast, free parking, and a 24-hour front desk. Our guests praise the helpful staff ...
Super 8 by Wyndham Greenville

Super 8 by Wyndham Greenville

1700 State Route 127 Greenville IL
2.63 km from city center
Book a stay at this business-friendly motel in Greenville. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Budget Inn Motel

Budget Inn Motel

1525 South State Rt 127 Greenville IL
2.46 km from city center
Stay at this motel in Greenville. Enjoy free WiFi, free parking, and room service. Popular attractions Greenville Country Club and Patriot's Park are located ...
Seasons Inn & Suites Highland

Seasons Inn & Suites Highland

20 Central Blvd Highland IL
27.99 km from city center
Book a stay at this business-friendly hotel in Highland. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Baymont by Wyndham Litchfield

Baymont by Wyndham Litchfield

1405 W Hudson Dr Litchfield IL
38.61 km from city center
Book a stay at this business-friendly hotel in Litchfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Quality Inn Litchfield Route 66

Quality Inn Litchfield Route 66

1010 E Columbian Blvd N Litchfield IL
38.95 km from city center
Book a stay at this business-friendly hotel in Litchfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Best Western Plus Centralia Hotel & Suites

Best Western Plus Centralia Hotel & Suites

8145 Jolliff Bridge Rd Centralia IL
45.47 km from city center
Book a stay at this business-friendly hotel in Centralia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Holiday Inn Express & Suites Vandalia by IHG

Holiday Inn Express & Suites Vandalia by IHG

21 Mattes Ave Vandalia IL
25.71 km from city center
Book a stay at this business-friendly hotel in Vandalia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Quality Inn & Suites Vandalia near I-70 and Hwy 51

Quality Inn & Suites Vandalia near I-70 and Hwy 51

1920 Kennedy Boulevard Vandalia IL
28.99 km from city center
Book a stay at this business-friendly hotel in Vandalia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Hampton Inn by Hilton Litchfield

Hampton Inn by Hilton Litchfield

11 Thunderbird Circle Litchfield IL
39.16 km from city center
Book a stay at this business-friendly hotel in Litchfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Ramada by Wyndham Vandalia

Ramada by Wyndham Vandalia

2707 Veterans Ave Vandalia IL
26.17 km from city center
Book a stay at this business-friendly hotel in Vandalia. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Holiday Inn Express & Suites Litchfield West by IHG

Holiday Inn Express & Suites Litchfield West by IHG

4 Thunderbird Circle Litchfield IL
39.07 km from city center
Book a stay at this business-friendly hotel in Litchfield. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Super 8 by Wyndham Staunton

Super 8 by Wyndham Staunton

1527 Herman Rd Staunton IL
33.21 km from city center
Book a stay at this business-friendly hotel in Staunton. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
Motel 6 Litchfield, IL

Motel 6 Litchfield, IL

211 Ohren Lane Litchfield IL
38.62 km from city center
Stay at this motel in Litchfield. Enjoy free WiFi, free parking, and a 24-hour front desk. Popular attractions Litchfield Museum and Route 66 Welcome Center ...
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.