Cayos Zapatilla Vacation Packages for 2025

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Cayos Zapatilla Flight + Hotel packages

Price found within the past 48 hours. Click for updated prices.
MARINN Tropical Vibes Hotel

MARINN Tropical Vibes Hotel

3.5 out of 5
Amador
per person
Oct 23 - Oct 27
found 4 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to Panama City (PTY)
Stay at this 3.5-star hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Albrook Shopping Mall and Amador Causeway are located nearby.

Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5 out of 5
Bella Vista
per person
Oct 23 - Oct 27
found 4 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to Panama City (PTY)
Book a stay at this luxury hotel in Panama City. Enjoy free WiFi, free valet parking, and a full-service spa. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Via Espana are located nearby.

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
per person
Oct 23 - Oct 27
found 4 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to Panama City (PTY)
Stay at this 4-star spa hotel in Panama City. Enjoy free WiFi, a full-service spa, and 3 restaurants. Our guests praise the helpful staff and the clean rooms in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Hotel Plaza Herrera

Hotel Plaza Herrera

4 out of 5
Casco Viejo
per person
Oct 23 - Oct 27
found 4 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to Panama City (PTY)
Stay at this 4-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and an attached winery. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
San Francisco
per person
Oct 23 - Oct 27
found 4 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to Panama City (PTY)
Stay at this 3.5-star business-friendly hotel in Panama City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the pool in our reviews. Popular attractions Albrook Shopping Mall and Avenida Balboa are located nearby.

La Concordia Boutique Hotel

La Concordia Boutique Hotel

4 out of 5
Casco Viejo
per person
Oct 23 - Oct 27
found 4 hours ago
Roundtrip non-stop flight included
Chicago (ORD) to Panama City (PTY)
Stay at this 4-star family-friendly hotel in Panama City. Enjoy free WiFi, a rooftop terrace, and onsite spa services. Our guests praise the helpful staff and the property condition in our reviews. Popular attractions Albrook Shopping Mall and Cinta Costera are located nearby.

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Top Hotel Deals

La Coralina Island House

La Coralina Island House

3.5 out of 5
Ruta Principal a Bluff, Playa Paunch., Bocas del Toro, Provincia de Bocas del Toro
24.19 km from city center
Stay at this 3.5-star beach hotel in Bocas del Toro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular ...
Punta Caracol Acqua Lodge

Punta Caracol Acqua Lodge

3.5 out of 5
Punta Caracol, Bocas del Toro, Bocas del Toro
29.95 km from city center
Stay at this 3.5-star beach lodge in Bocas del Toro. Enjoy free WiFi, breakfast (surcharge), and room service. Popular attractions La Gruta Cave and Institute ...
Tropical Suites Hotel

Tropical Suites Hotel

3.5 out of 5
First Street, Bocas Town, Bocas del Toro
22.37 km from city center
Stay at this 3.5-star business-friendly hotel in Bocas del Toro. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Bolivar Park and ...
Red Frog Beach Island Resort

Red Frog Beach Island Resort

4 out of 5
Isla Bastimentos, Bocas Town, Bocas del Toro, Bastimentos, Bocas del Toro
15.81 km from city center
Stay at this 4-star beach resort in Bastimentos. Enjoy free WiFi, private pools, and a full-service spa. Popular attractions Red Frog Beach and Bastimentos Sky ...
NAYARA Bocas del Toro

NAYARA Bocas del Toro

4 out of 5
Subdivision of Bocas del toro, Isla Frangipani, Bocas del Toro
18.82 km from city center
Stay at this 4-star spa hotel in Isla Frangipani. Enjoy free breakfast, free WiFi, and a full-service spa. Our guests praise the helpful staff in our ...
Cosmic Crab Resort

Cosmic Crab Resort

3 out of 5
Carenero Island Trail, Bocas del Toro, Bocas del Toro
22.13 km from city center
Stay at this 3-star beach hotel in Bocas del Toro. Enjoy free WiFi, 2 restaurants, and a beach locale. Popular attractions Bolivar Park and Bocas del Toro Ferry ...
Hotel Eclypse de Mar Acqua Lodge

Hotel Eclypse de Mar Acqua Lodge

3 out of 5
Bocas del Toro, Bastimentos
19.19 km from city center
Stay at this 3-star lodge in Bastimentos. Enjoy free WiFi, a marina, and room service. Our guests praise the helpful staff and the property condition in our ...
Bocas Paradise Hotel

Bocas Paradise Hotel

2.5 out of 5
Bocas Town, Bocas del Toro
22.36 km from city center
Stay at this hotel in Bocas del Toro. Enjoy free WiFi, free parking, and daily housekeeping. Our guests praise the helpful staff in our reviews. Popular attractions ...
Hotel Bocas del Toro

Hotel Bocas del Toro

3.5 out of 5
Calle Nº 2, Isla Colon, Bocas del Toro, Bocas del Toro
22.39 km from city center
Stay at this 3.5-star hotel in Bocas del Toro. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. ...
Bambuda Bocas Town - Hostel

Bambuda Bocas Town - Hostel

2.5 out of 5
Avenida H Norte entre Calle 5 y 6, Isla Colon Bocas del Toro, Bocas del Toro, Bocas del Toro
23.04 km from city center
Stay at this hostel in Bocas del Toro. Enjoy free WiFi, breakfast (surcharge), and a 24-hour front desk. Popular attractions Lil' Spa Shop by the Sea and Playa ...
Divers Paradise Boutique Hotel

Divers Paradise Boutique Hotel

3.5 out of 5
Calle 4ta Isla Colon, Avenida Sur, Bocas del Toro, Panama
22.35 km from city center
Stay at this 3.5-star hotel in Bocas del Toro. Enjoy free WiFi, breakfast (surcharge), and daily housekeeping. Our guests praise the helpful staff in our reviews. ...
Hotel Palma Royale

Hotel Palma Royale

3.5 out of 5
Calle 3ra, Bocas Town, Bocas del Toro, Panama
22.33 km from city center
Stay at this 3.5-star beach hotel in Bocas del Toro. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Bocas del Toro Ferry Terminal and ...
Surfari Bocas

Surfari Bocas

2.5 out of 5
Avenida B entre Calle 4 y 5, Bocas del Toro, Bocas del Toro
22.47 km from city center
Stay at this vacation home in Bocas del Toro. Enjoy free WiFi, a 24-hour front desk, and daily housekeeping. Popular attractions Bocas del Toro Ferry Terminal ...
Lula's Bed & Breakfast

Lula's Bed & Breakfast

3 out of 5
Av. H Nte., Bocas del Toro, Provincia de Bocas del Toro
23.06 km from city center
Stay at this 3-star B&B in Bocas del Toro. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff in our reviews. ...
Akwaba Lodge

Akwaba Lodge

4 out of 5
isla solarte, Bastimentos, bocas del toro
16.39 km from city center
Stay at this 4-star B&B in Bastimentos. Enjoy free breakfast, free WiFi, and daily housekeeping. Popular attractions Bastimentos Sky Zipline and Red Frog Beach ...
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See all available properties in Cayos Zapatilla
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Flight Deals

These prices were available within the past 7 days. Prices quoted are per person, round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Tue, Sep 23 - Tue, Oct 21
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$209 Roundtrip, found 4 hours ago
$209
Roundtrip
found 4 hours ago
Select Copa flight, departing Tue, Sep 23 from Juan Santamaría Intl. to Tocumen Intl., returning Tue, Oct 21, priced at $209 found 4 hours ago
avianca
Tue, Sep 23 - Tue, Oct 21
SJO
Juan Santamaría Intl.
PTY
Tocumen Intl.
$230 Roundtrip, found 4 hours ago
$230
Roundtrip
found 4 hours ago
Select avianca flight, departing Tue, Sep 23 from Juan Santamaría Intl. to Tocumen Intl., returning Tue, Oct 21, priced at $230 found 4 hours ago
American Airlines
Thu, Sep 25 - Sun, Sep 28
ATL
Hartsfield-Jackson Atlanta Intl.
PTY
Tocumen Intl.
$415 Roundtrip, found 23 hours ago
$415
Roundtrip
found 23 hours ago
Select American Airlines flight, departing Thu, Sep 25 from Hartsfield-Jackson Atlanta Intl. to Tocumen Intl., returning Sun, Sep 28, priced at $415 found 23 hours ago
Delta
Mon, Nov 3 - Mon, Nov 10
JFK
John F. Kennedy Intl.
PTY
Tocumen Intl.
$486 Roundtrip, found 5 days ago
$486
Roundtrip
found 5 days ago
Select Delta flight, departing Mon, Nov 3 from John F. Kennedy Intl. to Tocumen Intl., returning Mon, Nov 10, priced at $486 found 5 days ago
United
Tue, Aug 19 - Wed, Aug 20
FLL
Fort Lauderdale - Hollywood Intl.
PTY
Tocumen Intl.
$493 Roundtrip, found 5 days ago
$493
Roundtrip
found 5 days ago
Select United flight, departing Tue, Aug 19 from Fort Lauderdale - Hollywood Intl. to Tocumen Intl., returning Wed, Aug 20, priced at $493 found 5 days ago