2026 4 Star Hotels in Santa Cruz

Choose two or more items and save on your trip:

Featured Santa Cruz 4 Star Hotels

Hotel Fernando III

Hotel Fernando III

4 out of 5
San Jose 21 Seville Seville
Fully refundableReserve now, pay when you stay
Hotel Fernando III
Hotel Rey Alfonso X

Hotel Rey Alfonso X

4 out of 5
Calle Ximenez De Enciso, 35 Seville Seville
Hotel Rey Alfonso X
Las Casas de la Judería, Sevilla Historic City Center

Las Casas de la Judería, Sevilla Historic City Center

4 out of 5
Calle Santa Maria La Blanca 5 Seville Seville
Fully refundableReserve now, pay when you stay
Las Casas de la Judería, Sevilla Historic City Center
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Calle Farnesio 6 Seville Seville
Fully refundableReserve now, pay when you stay
Hotel Amadeus Sevilla
Petit Palace Santa Cruz

Petit Palace Santa Cruz

4 out of 5
Munoz y Pabón 18 Seville Seville
Petit Palace Santa Cruz
Hotel Doña Maria

Hotel Doña Maria

4 out of 5
Don Remondo 19 Seville Seville
Fully refundableReserve now, pay when you stay
Hotel Doña Maria
Hotel Boutique Casa del Poeta Sevilla

Hotel Boutique Casa del Poeta Sevilla

4 out of 5
Don Carlos Alonso Chaparro 3 Seville Seville
Fully refundableReserve now, pay when you stay
Hotel Boutique Casa del Poeta Sevilla
Legado Alcázar Hotel

Legado Alcázar Hotel

4 out of 5
Calle Mariana de Pineda, 18 Seville Sevilla
Legado Alcázar Hotel
El Rey Moro Hotel Boutique

El Rey Moro Hotel Boutique

4 out of 5
Reinoso, 8 Seville Seville
Fully refundableReserve now, pay when you stay
El Rey Moro Hotel Boutique
See all 432 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.